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Phosphoproteomics in drug discovery.

Morris MK, Chi A, Melas IN, Alexopoulos LG. Morris MK, et al. Among authors: melas in. Drug Discov Today. 2014 Apr;19(4):425-32. doi: 10.1016/j.drudis.2013.10.010. Epub 2013 Oct 18. Drug Discov Today. 2014. PMID: 24141136 Review.

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Leveraging systems biology approaches in clinical pharmacology.

Melas IN, Kretsos K, Alexopoulos LG. Melas IN, et al. Biopharm Drug Dispos. 2013 Dec;34(9):477-88. doi: 10.1002/bdd.1859. Epub 2013 Sep 17. Biopharm Drug Dispos. 2013. PMID: 23983165 Free PMC article. Review.

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Computational Approaches to Accelerating Novel Medicine and Better Patient Care from Bedside to Benchtop.

Sakellaropoulos T, Hur J, Melas IN, Guo EY, Alexopoulos L, Bohlooly M, Bai JP. Sakellaropoulos T, et al. Among authors: melas in. Adv Protein Chem Struct Biol. 2016;102:147-79. doi: 10.1016/bs.apcsb.2015.09.005. Epub 2015 Oct 29. Adv Protein Chem Struct Biol. 2016. PMID: 26827605 Review.

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A Computational Platform and Guide for Acceleration of Novel Medicines and Personalized Medicine.

Melas IN, Sakellaropoulos T, Hur J, Messinis D, Guo EY, Alexopoulos LG, Bai JPF. Melas IN, et al. Methods Mol Biol. 2019;1939:181-198. doi: 10.1007/978-1-4939-9089-4_10. Methods Mol Biol. 2019. PMID: 30848462

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Advances in omics for informed pharmaceutical research and development in the era of systems medicine.

Bai JPF, Melas IN, Hur J, Guo E. Bai JPF, et al. Among authors: melas in. Expert Opin Drug Discov. 2018 Jan;13(1):1-4. doi: 10.1080/17460441.2018.1394839. Epub 2017 Oct 27. Expert Opin Drug Discov. 2018. PMID: 29073782 No abstract available.

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Translational systems pharmacology-based predictive assessment of drug-induced cardiomyopathy.

Messinis DE, Melas IN, Hur J, Varshney N, Alexopoulos LG, Bai JPF. Messinis DE, et al. Among authors: melas in. CPT Pharmacometrics Syst Pharmacol. 2018 Mar;7(3):166-174. doi: 10.1002/psp4.12272. Epub 2018 Jan 17. CPT Pharmacometrics Syst Pharmacol. 2018. PMID: 29341478 Free PMC article.

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Modeling of signaling pathways in chondrocytes based on phosphoproteomic and cytokine release data.

Melas IN, Chairakaki AD, Chatzopoulou EI, Messinis DE, Katopodi T, Pliaka V, Samara S, Mitsos A, Dailiana Z, Kollia P, Alexopoulos LG. Melas IN, et al. Osteoarthritis Cartilage. 2014 Mar;22(3):509-18. doi: 10.1016/j.joca.2014.01.001. Epub 2014 Jan 21. Osteoarthritis Cartilage. 2014. PMID: 24457104 Free article.

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Signaling networks in MS: a systems-based approach to developing new pharmacological therapies.

Kotelnikova E, Bernardo-Faura M, Silberberg G, Kiani NA, Messinis D, Melas IN, Artigas L, Schwartz E, Mazo I, Masso M, Alexopoulos LG, Mas JM, Olsson T, Tegner J, Martin R, Zamora A, Paul F, Saez-Rodriguez J, Villoslada P. Kotelnikova E, et al. Among authors: melas in. Mult Scler. 2015 Feb;21(2):138-46. doi: 10.1177/1352458514543339. Epub 2014 Aug 11. Mult Scler. 2015. PMID: 25112814 Free article. Review.

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The species translation challenge-a systems biology perspective on human and rat bronchial epithelial cells.

Poussin C, Mathis C, Alexopoulos LG, Messinis DE, Dulize RH, Belcastro V, Melas IN, Sakellaropoulos T, Rhrissorrakrai K, Bilal E, Meyer P, Talikka M, Boué S, Norel R, Rice JJ, Stolovitzky G, Ivanov NV, Peitsch MC, Hoeng J. Poussin C, et al. Among authors: melas in. Sci Data. 2014 Jun 10;1:140009. doi: 10.1038/sdata.2014.9. eCollection 2014. Sci Data. 2014. PMID: 25977767 Free PMC article.

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Network reconstruction based on proteomic data and prior knowledge of protein connectivity using graph theory.

Stavrakas V, Melas IN, Sakellaropoulos T, Alexopoulos LG. Stavrakas V, et al. Among authors: melas in. PLoS One. 2015 May 28;10(5):e0128411. doi: 10.1371/journal.pone.0128411. eCollection 2015. PLoS One. 2015. PMID: 26020784 Free PMC article.

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