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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1958 1
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1960 5
1961 5
1962 1
1963 7
1964 19
1965 25
1966 23
1967 32
1968 52
1969 46
1970 52
1971 71
1972 59
1973 59
1974 71
1975 87
1976 102
1977 90
1978 116
1979 153
1980 131
1981 138
1982 174
1983 162
1984 186
1985 247
1986 261
1987 249
1988 314
1989 324
1990 344
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1992 384
1993 398
1994 413
1995 466
1996 529
1997 614
1998 652
1999 725
2000 653
2001 722
2002 724
2003 752
2004 654
2005 799
2006 865
2007 812
2008 837
2009 869
2010 932
2011 965
2012 1036
2013 1074
2014 1215
2015 1199
2016 1207
2017 1316
2018 1410
2019 1560
2020 1840
2021 1947
2022 2070
2023 1933
2024 1977
2025 538

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34,683 results

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Page 1
Is Melatonin the "Next Vitamin D"?: A Review of Emerging Science, Clinical Uses, Safety, and Dietary Supplements.
Minich DM, Henning M, Darley C, Fahoum M, Schuler CB, Frame J. Minich DM, et al. Nutrients. 2022 Sep 22;14(19):3934. doi: 10.3390/nu14193934. Nutrients. 2022. PMID: 36235587 Free PMC article. Review.
Melatonin has become a popular dietary supplement, most known as a chronobiotic, and for establishing healthy sleep. ...This review aims to evaluate the recent data on melatonin's mechanisms, its clinical uses beyond sleep, safety concerns, and a thorough sum …
Melatonin has become a popular dietary supplement, most known as a chronobiotic, and for establishing healthy sleep. ...This review a …
Melatonin: Physiological effects in humans.
Claustrat B, Leston J. Claustrat B, et al. Neurochirurgie. 2015 Apr-Jun;61(2-3):77-84. doi: 10.1016/j.neuchi.2015.03.002. Epub 2015 Apr 20. Neurochirurgie. 2015. PMID: 25908646 Review.
Melatonin is a methoxyindole synthesized and secreted principally by the pineal gland at night under normal light/dark conditions. ...It is admitted that a "physiological" dose provides plasma melatonin levels in the same order of magnitude as a nocturnal peak. Sinc …
Melatonin is a methoxyindole synthesized and secreted principally by the pineal gland at night under normal light/dark conditions. .. …
Melatonin as an antioxidant: under promises but over delivers.
Reiter RJ, Mayo JC, Tan DX, Sainz RM, Alatorre-Jimenez M, Qin L. Reiter RJ, et al. J Pineal Res. 2016 Oct;61(3):253-78. doi: 10.1111/jpi.12360. Epub 2016 Sep 1. J Pineal Res. 2016. PMID: 27500468 Review.
Melatonin's ubiquitous but unequal intracellular distribution, including its high concentrations in mitochondria, likely aid in its capacity to resist oxidative stress and cellular apoptosis. There is credible evidence to suggest that melatonin should be clas …
Melatonin's ubiquitous but unequal intracellular distribution, including its high concentrations in mitochondria, likely aid i …
Melatonin's Impact on Antioxidative and Anti-Inflammatory Reprogramming in Homeostasis and Disease.
Chitimus DM, Popescu MR, Voiculescu SE, Panaitescu AM, Pavel B, Zagrean L, Zagrean AM. Chitimus DM, et al. Biomolecules. 2020 Aug 20;10(9):1211. doi: 10.3390/biom10091211. Biomolecules. 2020. PMID: 32825327 Free PMC article. Review.
Melatonin promotes adaptation through allostasis and stands out as an endogenous, dietary, and therapeutic molecule with important health benefits. ...In addition, there might be an emerging role for melatonin as an adjuvant in treating coronavirus disease 2019 (COV …
Melatonin promotes adaptation through allostasis and stands out as an endogenous, dietary, and therapeutic molecule with important he …
Melatonin: exceeding expectations.
Reiter RJ, Tan DX, Galano A. Reiter RJ, et al. Physiology (Bethesda). 2014 Sep;29(5):325-33. doi: 10.1152/physiol.00011.2014. Physiology (Bethesda). 2014. PMID: 25180262 Free article. Review.
The receptor-independent actions relate to melatonin's ability to function in the detoxification of free radicals, thereby protecting critical molecules from the destructive effects of oxidative stress under conditions of ischemia/reperfusion injury (stroke, heart a …
The receptor-independent actions relate to melatonin's ability to function in the detoxification of free radicals, thereby pro …
Melatonin as a Potential Approach to Anxiety Treatment.
Repova K, Baka T, Krajcirovicova K, Stanko P, Aziriova S, Reiter RJ, Simko F. Repova K, et al. Int J Mol Sci. 2022 Dec 19;23(24):16187. doi: 10.3390/ijms232416187. Int J Mol Sci. 2022. PMID: 36555831 Free PMC article. Review.
This hormone influences a number of physiological actions either via specific melatonin receptors or by receptor-independent pleiotropic effects. The underlying pathomechanism of melatonin's benefit in anxiety may reside in its sympatholytic action, interacti …
This hormone influences a number of physiological actions either via specific melatonin receptors or by receptor-independent pleiotro …
Melatonin: From Pharmacokinetics to Clinical Use in Autism Spectrum Disorder.
Lalanne S, Fougerou-Leurent C, Anderson GM, Schroder CM, Nir T, Chokron S, Delorme R, Claustrat B, Bellissant E, Kermarrec S, Franco P, Denis L, Tordjman S. Lalanne S, et al. Int J Mol Sci. 2021 Feb 2;22(3):1490. doi: 10.3390/ijms22031490. Int J Mol Sci. 2021. PMID: 33540815 Free PMC article. Review.
However, melatonin's effects in ASD and the choice of formulation type require further study. Therapeutic benefits of melatonin on sleep disorders in ASD were observed, notably on sleep latency and sleep quality. ...A more thorough consideration of factors in …
However, melatonin's effects in ASD and the choice of formulation type require further study. Therapeutic benefits of melat …
Melatonin: the placental antioxidant and anti-inflammatory.
Joseph TT, Schuch V, Hossack DJ, Chakraborty R, Johnson EL. Joseph TT, et al. Front Immunol. 2024 Feb 1;15:1339304. doi: 10.3389/fimmu.2024.1339304. eCollection 2024. Front Immunol. 2024. PMID: 38361952 Free PMC article. Review.
Melatonin (N-acetyl-5-methoxytryptamine) is an indolamine hormone with many physiological and biological roles. ...This literature review aims to identify and summarize melatonin's role as a powerful antioxidant and anti-inflammatory that reduces oxidative st …
Melatonin (N-acetyl-5-methoxytryptamine) is an indolamine hormone with many physiological and biological roles. ...This literature re …
Melatonin as a Potent and Inducible Endogenous Antioxidant: Synthesis and Metabolism.
Tan DX, Manchester LC, Esteban-Zubero E, Zhou Z, Reiter RJ. Tan DX, et al. Molecules. 2015 Oct 16;20(10):18886-906. doi: 10.3390/molecules201018886. Molecules. 2015. PMID: 26501252 Free PMC article. Review.
Melatonin is a tryptophan-derived molecule with pleiotropic activities. It is present in almost all or all organisms. ...However, melatonin's synthetic mechanisms in microorganisms are currently unknown. Melatonin metabolism is highly complex with thes …
Melatonin is a tryptophan-derived molecule with pleiotropic activities. It is present in almost all or all organisms. ...However, …
Melatonin, a Full Service Anti-Cancer Agent: Inhibition of Initiation, Progression and Metastasis.
Reiter RJ, Rosales-Corral SA, Tan DX, Acuna-Castroviejo D, Qin L, Yang SF, Xu K. Reiter RJ, et al. Int J Mol Sci. 2017 Apr 17;18(4):843. doi: 10.3390/ijms18040843. Int J Mol Sci. 2017. PMID: 28420185 Free PMC article. Review.
There are several facets of this research which could have immediate applications at the clinical level. Many studies have shown that melatonin's co-administration improves the sensitivity of cancers to inhibition by conventional drugs. ...Even if the only beneficia …
There are several facets of this research which could have immediate applications at the clinical level. Many studies have shown that mel …
34,683 results
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