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Modulation of riboflavin biosynthesis and utilization in mycobacteria.
Chengalroyen MD, Mehaffy C, Lucas M, Bauer N, Raphela ML, Oketade N, Warner DF, Lewinsohn DA, Lewinsohn DM, Dobos KM, Mizrahi V. Chengalroyen MD, et al. Microbiol Spectr. 2024 Aug 6;12(8):e0320723. doi: 10.1128/spectrum.03207-23. Epub 2024 Jun 25. Microbiol Spectr. 2024. PMID: 38916330 Free PMC article.
Disruption of riboflavin biosynthesis in mycobacteria establishes riboflavin pathway intermediates as key precursors of MAIT cell agonists.
Chengalroyen MD, Oketade N, Worley A, Lucas M, Ramirez LMN, Raphela ML, Swarbrick GM, Soma PS, Zuma M, Warner DF, Lewinsohn DA, Mehaffy C, Adams EJ, Hildebrand W, Dobos KM, Mizrahi V, Lewinsohn DM. Chengalroyen MD, et al. PLoS Pathog. 2025 Jul 1;21(7):e1012632. doi: 10.1371/journal.ppat.1012632. eCollection 2025 Jul. PLoS Pathog. 2025. PMID: 40591719 Free PMC article.
Biological Profiling Enables Rapid Mechanistic Classification of Phenotypic Screening Hits and Identification of KatG Activation-Dependent Pyridine Carboxamide Prodrugs With Activity Against Mycobacterium tuberculosis.
Chengalroyen MD, Jordaan A, Seldon R, Ioerger T, Franzblau SG, Nasr M, Warner DF, Mizrahi V. Chengalroyen MD, et al. Front Cell Infect Microbiol. 2020 Nov 13;10:582416. doi: 10.3389/fcimb.2020.582416. eCollection 2020. Front Cell Infect Microbiol. 2020. PMID: 33282750 Free PMC article.