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Thyroid receptor ligands. Part 2: Thyromimetics with improved selectivity for the thyroid hormone receptor beta.
Hangeland JJ, Doweyko AM, Dejneka T, Friends TJ, Devasthale P, Mellström K, Sandberg J, Grynfarb M, Sack JS, Einspahr H, Färnegårdh M, Husman B, Ljunggren J, Koehler K, Sheppard C, Malm J, Ryono DE. Hangeland JJ, et al. Among authors: mellstrom k. Bioorg Med Chem Lett. 2004 Jul 5;14(13):3549-53. doi: 10.1016/j.bmcl.2004.04.032. Bioorg Med Chem Lett. 2004. PMID: 15177471
Selective thyroid hormone receptor-beta activation: a strategy for reduction of weight, cholesterol, and lipoprotein (a) with reduced cardiovascular liability.
Grover GJ, Mellström K, Ye L, Malm J, Li YL, Bladh LG, Sleph PG, Smith MA, George R, Vennström B, Mookhtiar K, Horvath R, Speelman J, Egan D, Baxter JD. Grover GJ, et al. Among authors: mellstrom k. Proc Natl Acad Sci U S A. 2003 Aug 19;100(17):10067-72. doi: 10.1073/pnas.1633737100. Epub 2003 Jul 29. Proc Natl Acad Sci U S A. 2003. PMID: 12888625 Free PMC article.
Thyroid receptor ligands. Part 8: Thyromimetics derived from N-acylated-alpha-amino acid derivatives displaying modulated pharmacological selectivity compared with KB-141.
Garg N, Li YL, Garcia Collazo AM, Litten C, Ryono DE, Zhang M, Caringal Y, Brigance RP, Meng W, Washburn WN, Agback P, Mellström K, Rehnmark S, Rahimi-Ghadim M, Norin T, Grynfarb M, Sandberg J, Grover G, Malm J. Garg N, et al. Among authors: mellstrom k. Bioorg Med Chem Lett. 2007 Aug 1;17(15):4131-4. doi: 10.1016/j.bmcl.2007.05.049. Epub 2007 May 21. Bioorg Med Chem Lett. 2007. PMID: 17543524
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