Meloche S - Search Results

1

From basic research to clinical development of MEK1/2 inhibitors for cancer therapy.

Frémin C, Meloche S. Frémin C, et al. Among authors: meloche s. J Hematol Oncol. 2010 Feb 11;3:8. doi: 10.1186/1756-8722-3-8. J Hematol Oncol. 2010. PMID: 20149254 Free PMC article. Review.

2

Genetic demonstration of a redundant role of extracellular signal-regulated kinase 1 (ERK1) and ERK2 mitogen-activated protein kinases in promoting fibroblast proliferation.

Voisin L, Saba-El-Leil MK, Julien C, Frémin C, Meloche S. Voisin L, et al. Among authors: meloche s. Mol Cell Biol. 2010 Jun;30(12):2918-32. doi: 10.1128/MCB.00131-10. Epub 2010 Apr 5. Mol Cell Biol. 2010. PMID: 20368360 Free PMC article.

3

Activation loop phosphorylation of ERK3/ERK4 by group I p21-activated kinases (PAKs) defines a novel PAK-ERK3/4-MAPK-activated protein kinase 5 signaling pathway.

Déléris P, Trost M, Topisirovic I, Tanguay PL, Borden KL, Thibault P, Meloche S. Déléris P, et al. Among authors: meloche s. J Biol Chem. 2011 Feb 25;286(8):6470-8. doi: 10.1074/jbc.M110.181529. Epub 2010 Dec 22. J Biol Chem. 2011. PMID: 21177870 Free PMC article.

4

Targeted inactivation of Mapk4 in mice reveals specific nonredundant functions of Erk3/Erk4 subfamily mitogen-activated protein kinases.

Rousseau J, Klinger S, Rachalski A, Turgeon B, Déléris P, Vigneault E, Poirier-Héon JF, Davoli MA, Mechawar N, El Mestikawy S, Cermakian N, Meloche S. Rousseau J, et al. Among authors: meloche s. Mol Cell Biol. 2010 Dec;30(24):5752-63. doi: 10.1128/MCB.01147-10. Epub 2010 Oct 18. Mol Cell Biol. 2010. PMID: 20956558 Free PMC article.

5

Activation loop phosphorylation of the atypical MAP kinases ERK3 and ERK4 is required for binding, activation and cytoplasmic relocalization of MK5.

Déléris P, Rousseau J, Coulombe P, Rodier G, Tanguay PL, Meloche S. Déléris P, et al. Among authors: meloche s. J Cell Physiol. 2008 Dec;217(3):778-88. doi: 10.1002/jcp.21560. J Cell Physiol. 2008. PMID: 18720373

6

An essential function of the mitogen-activated protein kinase Erk2 in mouse trophoblast development.

Saba-El-Leil MK, Vella FD, Vernay B, Voisin L, Chen L, Labrecque N, Ang SL, Meloche S. Saba-El-Leil MK, et al. Among authors: meloche s. EMBO Rep. 2003 Oct;4(10):964-8. doi: 10.1038/sj.embor.embor939. Epub 2003 Sep 19. EMBO Rep. 2003. PMID: 14502223 Free PMC article.

7

Rapid turnover of extracellular signal-regulated kinase 3 by the ubiquitin-proteasome pathway defines a novel paradigm of mitogen-activated protein kinase regulation during cellular differentiation.

Coulombe P, Rodier G, Pelletier S, Pellerin J, Meloche S. Coulombe P, et al. Among authors: meloche s. Mol Cell Biol. 2003 Jul;23(13):4542-58. doi: 10.1128/mcb.23.13.4542-4558.2003. Mol Cell Biol. 2003. PMID: 12808096 Free PMC article.

8

Negative regulation of MAPKK by phosphorylation of a conserved serine residue equivalent to Ser212 of MEK1.

Gopalbhai K, Jansen G, Beauregard G, Whiteway M, Dumas F, Wu C, Meloche S. Gopalbhai K, et al. Among authors: meloche s. J Biol Chem. 2003 Mar 7;278(10):8118-25. doi: 10.1074/jbc.M211870200. Epub 2002 Dec 27. J Biol Chem. 2003. PMID: 12506122

9

Visualization of Endogenous ERK1/2 in Cells with a Bioorthogonal Covalent Probe.

Sipthorp J, Lebraud H, Gilley R, Kidger AM, Okkenhaug H, Saba-El-Leil M, Meloche S, Caunt CJ, Cook SJ, Heightman TD. Sipthorp J, et al. Among authors: meloche s. Bioconjug Chem. 2017 Jun 21;28(6):1677-1683. doi: 10.1021/acs.bioconjchem.7b00152. Epub 2017 May 12. Bioconjug Chem. 2017. PMID: 28449575 Free article.

10

Loss of Extracellular Signal-Regulated Kinase 1/2 in the Retinal Pigment Epithelium Leads to RPE65 Decrease and Retinal Degeneration.

Pyakurel A, Balmer D, Saba-El-Leil MK, Kizilyaprak C, Daraspe J, Humbel BM, Voisin L, Le YZ, von Lintig J, Meloche S, Roduit R. Pyakurel A, et al. Among authors: meloche s. Mol Cell Biol. 2017 Nov 28;37(24):e00295-17. doi: 10.1128/MCB.00295-17. Print 2017 Dec 15. Mol Cell Biol. 2017. PMID: 29038159 Free PMC article.

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