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Catechols and 3-hydroxypyridones as inhibitors of the DNA repair complex ERCC1-XPF.
Chapman TM, Gillen KJ, Wallace C, Lee MT, Bakrania P, Khurana P, Coombs PJ, Stennett L, Fox S, Bureau EA, Brownlees J, Melton DW, Saxty B. Chapman TM, et al. Among authors: melton dw. Bioorg Med Chem Lett. 2015 Oct 1;25(19):4097-103. doi: 10.1016/j.bmcl.2015.08.031. Epub 2015 Aug 17. Bioorg Med Chem Lett. 2015. PMID: 26318993
The toxicity of nitrofuran compounds on melanoma and neuroblastoma cells is enhanced by Olaparib and ameliorated by melanin pigment.
McNeil EM, Ritchie AM, Melton DW. McNeil EM, et al. Among authors: melton dw. DNA Repair (Amst). 2013 Nov;12(11):1000-6. doi: 10.1016/j.dnarep.2013.08.017. Epub 2013 Sep 23. DNA Repair (Amst). 2013. PMID: 24070777
Inhibition of the ERCC1-XPF structure-specific endonuclease to overcome cancer chemoresistance.
McNeil EM, Astell KR, Ritchie AM, Shave S, Houston DR, Bakrania P, Jones HM, Khurana P, Wallace C, Chapman T, Wear MA, Walkinshaw MD, Saxty B, Melton DW. McNeil EM, et al. Among authors: melton dw. DNA Repair (Amst). 2015 Jul;31:19-28. doi: 10.1016/j.dnarep.2015.04.002. Epub 2015 Apr 22. DNA Repair (Amst). 2015. PMID: 25956741
DNA repair endonuclease ERCC1-XPF as a novel therapeutic target to overcome chemoresistance in cancer therapy.
McNeil EM, Melton DW. McNeil EM, et al. Among authors: melton dw. Nucleic Acids Res. 2012 Nov 1;40(20):9990-10004. doi: 10.1093/nar/gks818. Epub 2012 Aug 31. Nucleic Acids Res. 2012. PMID: 22941649 Free PMC article. Review.
Mice with DNA repair gene Ercc1 deficiency in a neural crest lineage are a model for late-onset Hirschsprung disease.
Selfridge J, Song L, Brownstein DG, Melton DW. Selfridge J, et al. Among authors: melton dw. DNA Repair (Amst). 2010 Jun 4;9(6):653-60. doi: 10.1016/j.dnarep.2010.02.018. Epub 2010 Apr 1. DNA Repair (Amst). 2010. PMID: 20362516
N-Hydroxyimides and hydroxypyrimidinones as inhibitors of the DNA repair complex ERCC1-XPF.
Chapman TM, Wallace C, Gillen KJ, Bakrania P, Khurana P, Coombs PJ, Fox S, Bureau EA, Brownlees J, Melton DW, Saxty B. Chapman TM, et al. Among authors: melton dw. Bioorg Med Chem Lett. 2015 Oct 1;25(19):4104-8. doi: 10.1016/j.bmcl.2015.08.024. Epub 2015 Aug 14. Bioorg Med Chem Lett. 2015. PMID: 26321360
Disruption of DNA repair in cancer cells by ubiquitination of a destabilising dimerization domain of nucleotide excision repair protein ERCC1.
Yang L, Ritchie AM, Melton DW. Yang L, et al. Among authors: melton dw. Oncotarget. 2017 Jul 21;8(33):55246-55264. doi: 10.18632/oncotarget.19422. eCollection 2017 Aug 15. Oncotarget. 2017. PMID: 28903417 Free PMC article.
Identification of DNA repair gene Ercc1 as a novel target in melanoma.
Song L, Ritchie AM, McNeil EM, Li W, Melton DW. Song L, et al. Among authors: melton dw. Pigment Cell Melanoma Res. 2011 Oct;24(5):966-71. doi: 10.1111/j.1755-148X.2011.00882.x. Epub 2011 Jul 28. Pigment Cell Melanoma Res. 2011. PMID: 21722328
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