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Subcapsular sinus macrophages in lymph nodes clear lymph-borne viruses and present them to antiviral B cells.
Junt T, Moseman EA, Iannacone M, Massberg S, Lang PA, Boes M, Fink K, Henrickson SE, Shayakhmetov DM, Di Paolo NC, van Rooijen N, Mempel TR, Whelan SP, von Andrian UH. Junt T, et al. Among authors: Mempel TR. Nature. 2007 Nov 1;450(7166):110-4. doi: 10.1038/nature06287. Epub 2007 Oct 14. Nature. 2007. PMID: 17934446
T cell sensing of antigen dose governs interactive behavior with dendritic cells and sets a threshold for T cell activation.
Henrickson SE, Mempel TR, Mazo IB, Liu B, Artyomov MN, Zheng H, Peixoto A, Flynn MP, Senman B, Junt T, Wong HC, Chakraborty AK, von Andrian UH. Henrickson SE, et al. Among authors: Mempel TR. Nat Immunol. 2008 Mar;9(3):282-91. doi: 10.1038/ni1559. Epub 2008 Jan 20. Nat Immunol. 2008. PMID: 18204450 Free PMC article.
HIV-infected T cells are migratory vehicles for viral dissemination.
Murooka TT, Deruaz M, Marangoni F, Vrbanac VD, Seung E, von Andrian UH, Tager AM, Luster AD, Mempel TR. Murooka TT, et al. Among authors: Mempel TR. Nature. 2012 Oct 11;490(7419):283-7. doi: 10.1038/nature11398. Epub 2012 Aug 1. Nature. 2012. PMID: 22854780 Free PMC article.
Adding new dimensions: towards an integrative understanding of HIV-1 spread.
Fackler OT, Murooka TT, Imle A, Mempel TR. Fackler OT, et al. Among authors: Mempel TR. Nat Rev Microbiol. 2014 Aug;12(8):563-74. doi: 10.1038/nrmicro3309. Nat Rev Microbiol. 2014. PMID: 25029025 Free PMC article. Review.
The transcription factor NFAT promotes exhaustion of activated CD8⁺ T cells.
Martinez GJ, Pereira RM, Äijö T, Kim EY, Marangoni F, Pipkin ME, Togher S, Heissmeyer V, Zhang YC, Crotty S, Lamperti ED, Ansel KM, Mempel TR, Lähdesmäki H, Hogan PG, Rao A. Martinez GJ, et al. Among authors: Mempel TR. Immunity. 2015 Feb 17;42(2):265-278. doi: 10.1016/j.immuni.2015.01.006. Epub 2015 Feb 10. Immunity. 2015. PMID: 25680272 Free PMC article.
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