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Cognitive deficits in transgenic and knock-in HTT mice parallel those in Huntington's disease.
Farrar AM, Murphy CA, Paterson NE, Oakeshott S, He D, Alosio W, McConnell K, Menalled LB, Ramboz S, Park LC, Howland D, Brunner D. Farrar AM, et al. Among authors: menalled lb. J Huntingtons Dis. 2014;3(2):145-58. doi: 10.3233/JHD-130061. J Huntingtons Dis. 2014. PMID: 25062858
Comprehensive behavioral and molecular characterization of a new knock-in mouse model of Huntington's disease: zQ175.
Menalled LB, Kudwa AE, Miller S, Fitzpatrick J, Watson-Johnson J, Keating N, Ruiz M, Mushlin R, Alosio W, McConnell K, Connor D, Murphy C, Oakeshott S, Kwan M, Beltran J, Ghavami A, Brunner D, Park LC, Ramboz S, Howland D. Menalled LB, et al. PLoS One. 2012;7(12):e49838. doi: 10.1371/journal.pone.0049838. Epub 2012 Dec 20. PLoS One. 2012. PMID: 23284626 Free PMC article.
Knock-in mouse models of Huntington's disease.
Menalled LB. Menalled LB. NeuroRx. 2005 Jul;2(3):465-70. doi: 10.1602/neurorx.2.3.465. NeuroRx. 2005. PMID: 16389309 Free PMC article. Review.
Mouse models of Huntington's disease.
Menalled LB, Chesselet MF. Menalled LB, et al. Trends Pharmacol Sci. 2002 Jan;23(1):32-9. doi: 10.1016/s0165-6147(00)01884-8. Trends Pharmacol Sci. 2002. PMID: 11804649 Review.
Early motor dysfunction and striosomal distribution of huntingtin microaggregates in Huntington's disease knock-in mice.
Menalled LB, Sison JD, Wu Y, Olivieri M, Li XJ, Li H, Zeitlin S, Chesselet MF. Menalled LB, et al. J Neurosci. 2002 Sep 15;22(18):8266-76. doi: 10.1523/JNEUROSCI.22-18-08266.2002. J Neurosci. 2002. PMID: 12223581 Free PMC article.
Large-scale phenome analysis defines a behavioral signature for Huntington's disease genotype in mice.
Alexandrov V, Brunner D, Menalled LB, Kudwa A, Watson-Johnson J, Mazzella M, Russell I, Ruiz MC, Torello J, Sabath E, Sanchez A, Gomez M, Filipov I, Cox K, Kwan M, Ghavami A, Ramboz S, Lager B, Wheeler VC, Aaronson J, Rosinski J, Gusella JF, MacDonald ME, Howland D, Kwak S. Alexandrov V, et al. Among authors: menalled lb. Nat Biotechnol. 2016 Aug;34(8):838-44. doi: 10.1038/nbt.3587. Epub 2016 Jul 4. Nat Biotechnol. 2016. PMID: 27376585
Genetic deletion of transglutaminase 2 does not rescue the phenotypic deficits observed in R6/2 and zQ175 mouse models of Huntington's disease.
Menalled LB, Kudwa AE, Oakeshott S, Farrar A, Paterson N, Filippov I, Miller S, Kwan M, Olsen M, Beltran J, Torello J, Fitzpatrick J, Mushlin R, Cox K, McConnell K, Mazzella M, He D, Osborne GF, Al-Nackkash R, Bates GP, Tuunanen P, Lehtimaki K, Brunner D, Ghavami A, Ramboz S, Park L, Macdonald D, Munoz-Sanjuan I, Howland D. Menalled LB, et al. PLoS One. 2014 Jun 23;9(6):e99520. doi: 10.1371/journal.pone.0099520. eCollection 2014. PLoS One. 2014. PMID: 24955833 Free PMC article.
Increased Body Weight of the BAC HD Transgenic Mouse Model of Huntington's Disease Accounts for Some but Not All of the Observed HD-like Motor Deficits.
Kudwa AE, Menalled LB, Oakeshott S, Murphy C, Mushlin R, Fitzpatrick J, Miller SF, McConnell K, Port R, Torello J, Howland D, Ramboz S, Brunner D. Kudwa AE, et al. Among authors: menalled lb. PLoS Curr. 2013 Jul 30;5:ecurrents.hd.0ab4f3645aff523c56ecc8ccbe41a198. doi: 10.1371/currents.hd.0ab4f3645aff523c56ecc8ccbe41a198. PLoS Curr. 2013. PMID: 24042107 Free PMC article.
Comprehensive behavioral testing in the R6/2 mouse model of Huntington's disease shows no benefit from CoQ10 or minocycline.
Menalled LB, Patry M, Ragland N, Lowden PA, Goodman J, Minnich J, Zahasky B, Park L, Leeds J, Howland D, Signer E, Tobin AJ, Brunner D. Menalled LB, et al. PLoS One. 2010 Mar 22;5(3):e9793. doi: 10.1371/journal.pone.0009793. PLoS One. 2010. PMID: 20339553 Free PMC article.
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