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Quantifying phenotypic variation in isogenic Caenorhabditis elegans expressing Phsp-16.2::gfp by clustering 2D expression patterns.
Seewald AK, Cypser J, Mendenhall A, Johnson T. Seewald AK, et al. PLoS One. 2010 Jul 19;5(7):e11426. doi: 10.1371/journal.pone.0011426. PLoS One. 2010. PMID: 20657830 Free PMC article.
Isogenic populations of animals still show a surprisingly large amount of phenotypic variation between individuals. Using a GFP reporter that has been shown to predict longevity and resistance to stress in isogenic populations of the nematode Caenorhabditis elegans, …
Isogenic populations of animals still show a surprisingly large amount of phenotypic variation between individuals. Using a GF …
Environmental Canalization of Life Span and Gene Expression in Caenorhabditis elegans.
Mendenhall A, Crane MM, Leiser S, Sutphin G, Tedesco PM, Kaeberlein M, Johnson TE, Brent R. Mendenhall A, et al. J Gerontol A Biol Sci Med Sci. 2017 Aug 1;72(8):1033-1037. doi: 10.1093/gerona/glx017. J Gerontol A Biol Sci Med Sci. 2017. PMID: 28369388 Free PMC article.
Specifically, we examined, in Caenorhabditis elegans, how different temperatures (15°C, 20°C, and 25°C) affected the amount of interindividual variation in life span and also expression of three reporter genes-transcriptional reporters for vit-2, gpd-2, and hsp-16.2 (a lif …
Specifically, we examined, in Caenorhabditis elegans, how different temperatures (15°C, 20°C, and 25°C) affected the amount of interindividu …
Caenorhabditis elegans Genes Affecting Interindividual Variation in Life-span Biomarker Gene Expression.
Mendenhall A, Crane MM, Tedesco PM, Johnson TE, Brent R. Mendenhall A, et al. J Gerontol A Biol Sci Med Sci. 2017 Oct 1;72(10):1305-1310. doi: 10.1093/gerona/glw349. J Gerontol A Biol Sci Med Sci. 2017. PMID: 28158434 Free PMC article.
Differences in one such trait, expression of a single biomarker gene, can identify isogenic cells or organisms that later manifest different fates. ...Our results show that specific signaling systems regulate not only expression level, but also the amount of interindividua …
Differences in one such trait, expression of a single biomarker gene, can identify isogenic cells or organisms that later manifest di …
Pattern Formation in the Longevity-Related Expression of Heat Shock Protein-16.2 in Caenorhabditis elegans.
Wentz JM, Mendenhall AR, Bortz DM. Wentz JM, et al. Among authors: mendenhall ar. Bull Math Biol. 2018 Oct;80(10):2669-2697. doi: 10.1007/s11538-018-0482-7. Epub 2018 Aug 10. Bull Math Biol. 2018. PMID: 30097920 Free PMC article.
Single Cell Quantification of Reporter Gene Expression in Live Adult Caenorhabditis elegans Reveals Reproducible Cell-Specific Expression Patterns and Underlying Biological Variation.
Mendenhall AR, Tedesco PM, Sands B, Johnson TE, Brent R. Mendenhall AR, et al. PLoS One. 2015 May 6;10(5):e0124289. doi: 10.1371/journal.pone.0124289. eCollection 2015. PLoS One. 2015. PMID: 25946008 Free PMC article.
Expression of a single-copy hsp-16.2 reporter predicts life span.
Mendenhall AR, Tedesco PM, Taylor LD, Lowe A, Cypser JR, Johnson TE. Mendenhall AR, et al. J Gerontol A Biol Sci Med Sci. 2012 Jun;67(7):726-33. doi: 10.1093/gerona/glr225. Epub 2012 Jan 6. J Gerontol A Biol Sci Med Sci. 2012. PMID: 22227523 Free PMC article.
The initial report used a high-copy number reporter integrated into chromosome IV. There was concern that the life-span prediction power of this reporter was not attributable solely to hsp-16.2 output. ...Here we determine if the ability to predict life span and thermotole …
The initial report used a high-copy number reporter integrated into chromosome IV. There was concern that the life-span prediction po …
Predicting longevity in C. elegans: fertility, mobility and gene expression.
Cypser JR, Wu D, Park SK, Ishii T, Tedesco PM, Mendenhall AR, Johnson TE. Cypser JR, et al. Mech Ageing Dev. 2013 Jul-Aug;134(7-8):291-7. doi: 10.1016/j.mad.2013.02.003. Epub 2013 Feb 13. Mech Ageing Dev. 2013. PMID: 23416266
Expression level of an hsp-16.2::gfp transgene is a predictor of longevity in Caenorhabditis elegans. Here we examine fertility, movement and longevity, comparing high-expressing ("bright") and low-expressing ("dim") animals. ...These results suggest that a robust p …
Expression level of an hsp-16.2::gfp transgene is a predictor of longevity in Caenorhabditis elegans. Here we examine fertility, move …
Genetic dissection of late-life fertility in Caenorhabditis elegans.
Mendenhall AR, Wu D, Park SK, Cypser JR, Tedesco PM, Link CD, Phillips PC, Johnson TE. Mendenhall AR, et al. J Gerontol A Biol Sci Med Sci. 2011 Aug;66(8):842-54. doi: 10.1093/gerona/glr089. Epub 2011 May 28. J Gerontol A Biol Sci Med Sci. 2011. PMID: 21622982 Free PMC article.
Species with long post-reproductive life spans such as mammals are sometimes explained by a need for parental care or transfer of information. This does not seem a suitable explanation for C elegans. Previous reports have shown that C elegans can regain fertility wh …
Species with long post-reproductive life spans such as mammals are sometimes explained by a need for parental care or transfer of inf …
Using measures of single-cell physiology and physiological state to understand organismic aging.
Mendenhall A, Driscoll M, Brent R. Mendenhall A, et al. Aging Cell. 2016 Feb;15(1):4-13. doi: 10.1111/acel.12424. Epub 2015 Nov 29. Aging Cell. 2016. PMID: 26616110 Free PMC article. Review.
While some single-cell states, for example, responses to oxygen deprivation, were defined previously, others, such as a generally heightened ability to make proteins, were, revealed by direct experiment only recently, and are not well understood. ...For these reasons, quan …
While some single-cell states, for example, responses to oxygen deprivation, were defined previously, others, such as a generally hei …
Reactivation of RNA metabolism underlies somatic restoration after adult reproductive diapause in C. elegans.
Burnaevskiy N, Chen S, Mailig M, Reynolds A, Karanth S, Mendenhall A, Van Gilst M, Kaeberlein M. Burnaevskiy N, et al. Among authors: mendenhall a. Elife. 2018 Aug 2;7:e36194. doi: 10.7554/eLife.36194. Elife. 2018. PMID: 30070633 Free PMC article.
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