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The extra virgin olive oil phenolic oleacein is a dual substrate-inhibitor of catechol-O-methyltransferase.
Cuyàs E, Verdura S, Lozano-Sánchez J, Viciano I, Llorach-Parés L, Nonell-Canals A, Bosch-Barrera J, Brunet J, Segura-Carretero A, Sanchez-Martinez M, Encinar JA, Menendez JA. Cuyàs E, et al. Among authors: menendez ja. Food Chem Toxicol. 2019 Jun;128:35-45. doi: 10.1016/j.fct.2019.03.049. Epub 2019 Mar 29. Food Chem Toxicol. 2019. PMID: 30935952
Extra Virgin Olive Oil Contains a Phenolic Inhibitor of the Histone Demethylase LSD1/KDM1A.
Cuyàs E, Gumuzio J, Lozano-Sánchez J, Carreras D, Verdura S, Llorach-Parés L, Sanchez-Martinez M, Selga E, Pérez GJ, Scornik FS, Brugada R, Bosch-Barrera J, Segura-Carretero A, Martin ÁG, Encinar JA, Menendez JA. Cuyàs E, et al. Among authors: menendez ja. Nutrients. 2019 Jul 19;11(7):1656. doi: 10.3390/nu11071656. Nutrients. 2019. PMID: 31331073 Free PMC article.
The LSD1 inhibitor iadademstat (ORY-1001) targets SOX2-driven breast cancer stem cells: a potential epigenetic therapy in luminal-B and HER2-positive breast cancer subtypes.
Cuyàs E, Gumuzio J, Verdura S, Brunet J, Bosch-Barrera J, Martin-Castillo B, Alarcón T, Encinar JA, Martin ÁG, Menendez JA. Cuyàs E, et al. Among authors: menendez ja. Aging (Albany NY). 2020 Mar 18;12(6):4794-4814. doi: 10.18632/aging.102887. Epub 2020 Mar 18. Aging (Albany NY). 2020. PMID: 32191225 Free PMC article.
Metformin Is a Pyridoxal-5'-phosphate (PLP)-Competitive Inhibitor of SHMT2.
Tramonti A, Cuyàs E, Encinar JA, Pietzke M, Paone A, Verdura S, Arbusà A, Martin-Castillo B, Giardina G, Joven J, Vazquez A, Contestabile R, Cutruzzolà F, Menendez JA. Tramonti A, et al. Among authors: menendez ja. Cancers (Basel). 2021 Aug 9;13(16):4009. doi: 10.3390/cancers13164009. Cancers (Basel). 2021. PMID: 34439169 Free PMC article.
374 results