Preliminary X-ray analysis of crystals of fasciculin 1, a potent acetylcholinesterase inhibitor from green mamba venom

R Ménez; A Ducruix

doi:10.1016/S0022-2836(05)80313-4

Preliminary X-ray analysis of crystals of fasciculin 1, a potent acetylcholinesterase inhibitor from green mamba venom

J Mol Biol. 1990 Nov 20;216(2):233-4. doi: 10.1016/S0022-2836(05)80313-4.

Authors

R Ménez¹, A Ducruix

Affiliation

¹ Institut de Chimie des Substances Naturelles, CNRS 91198, Gif-sur-Yvette, France.

PMID: 2254925
DOI: 10.1016/S0022-2836(05)80313-4

Abstract

Fasciculin 1 from Dendroaspis angusticeps has been crystallized by vapour diffusion, in sodium acetate using sodium thiocyanate as precipitant. Tetragonal crystals (space group P4(1)2(1)2 or P4(3)2(1)2) diffract to 1.8 A resolution. The unit cell parameters are a = 40.4 A and c = 81.1 A. We estimated the presence of one molecule in the asymmetric unit.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Cholinesterase Inhibitors / chemistry*
Elapid Venoms / chemistry*
Elapid Venoms / isolation & purification
Protein Conformation
X-Ray Diffraction

Substances

Cholinesterase Inhibitors
Elapid Venoms
fasciculin