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TGF-β: the master regulator of fibrosis.
Meng XM, Nikolic-Paterson DJ, Lan HY. Meng XM, et al. Nat Rev Nephrol. 2016 Jun;12(6):325-38. doi: 10.1038/nrneph.2016.48. Epub 2016 Apr 25. Nat Rev Nephrol. 2016. PMID: 27108839 Review.
miR-192 mediates TGF-beta/Smad3-driven renal fibrosis.
Chung AC, Huang XR, Meng X, Lan HY. Chung AC, et al. Among authors: meng x. J Am Soc Nephrol. 2010 Aug;21(8):1317-25. doi: 10.1681/ASN.2010020134. Epub 2010 May 20. J Am Soc Nephrol. 2010. PMID: 20488955 Free PMC article.
Smad2 protects against TGF-beta/Smad3-mediated renal fibrosis.
Meng XM, Huang XR, Chung AC, Qin W, Shao X, Igarashi P, Ju W, Bottinger EP, Lan HY. Meng XM, et al. J Am Soc Nephrol. 2010 Sep;21(9):1477-87. doi: 10.1681/ASN.2009121244. Epub 2010 Jul 1. J Am Soc Nephrol. 2010. PMID: 20595680 Free PMC article.
TGF-β/Smad3 signaling promotes renal fibrosis by inhibiting miR-29.
Qin W, Chung AC, Huang XR, Meng XM, Hui DS, Yu CM, Sung JJ, Lan HY. Qin W, et al. Among authors: meng xm. J Am Soc Nephrol. 2011 Aug;22(8):1462-74. doi: 10.1681/ASN.2010121308. Epub 2011 Jul 22. J Am Soc Nephrol. 2011. PMID: 21784902 Free PMC article.
Smad3-mediated upregulation of miR-21 promotes renal fibrosis.
Zhong X, Chung AC, Chen HY, Meng XM, Lan HY. Zhong X, et al. Among authors: meng xm. J Am Soc Nephrol. 2011 Sep;22(9):1668-81. doi: 10.1681/ASN.2010111168. Epub 2011 Aug 18. J Am Soc Nephrol. 2011. PMID: 21852586 Free PMC article.
Disruption of Smad4 impairs TGF-β/Smad3 and Smad7 transcriptional regulation during renal inflammation and fibrosis in vivo and in vitro.
Meng XM, Huang XR, Xiao J, Chung AC, Qin W, Chen HY, Lan HY. Meng XM, et al. Kidney Int. 2012 Feb;81(3):266-79. doi: 10.1038/ki.2011.327. Epub 2011 Nov 2. Kidney Int. 2012. PMID: 22048127
Diverse roles of TGF-β receptor II in renal fibrosis and inflammation in vivo and in vitro.
Meng XM, Huang XR, Xiao J, Chen HY, Zhong X, Chung AC, Lan HY. Meng XM, et al. J Pathol. 2012 Jun;227(2):175-88. doi: 10.1002/path.3976. Epub 2012 Feb 22. J Pathol. 2012. PMID: 22190171
Asiatic acid inhibits liver fibrosis by blocking TGF-beta/Smad signaling in vivo and in vitro.
Tang LX, He RH, Yang G, Tan JJ, Zhou L, Meng XM, Huang XR, Lan HY. Tang LX, et al. Among authors: meng xm. PLoS One. 2012;7(2):e31350. doi: 10.1371/journal.pone.0031350. Epub 2012 Feb 7. PLoS One. 2012. PMID: 22363627 Free PMC article.
miR-29 inhibits bleomycin-induced pulmonary fibrosis in mice.
Xiao J, Meng XM, Huang XR, Chung AC, Feng YL, Hui DS, Yu CM, Sung JJ, Lan HY. Xiao J, et al. Among authors: meng xm. Mol Ther. 2012 Jun;20(6):1251-60. doi: 10.1038/mt.2012.36. Epub 2012 Mar 6. Mol Ther. 2012. PMID: 22395530 Free PMC article.
Role of the TGF-β/BMP-7/Smad pathways in renal diseases.
Meng XM, Chung AC, Lan HY. Meng XM, et al. Clin Sci (Lond). 2013 Feb;124(4):243-54. doi: 10.1042/CS20120252. Clin Sci (Lond). 2013. PMID: 23126427 Review.
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