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Mitigation of whole-body gamma radiation-induced damages by Clerodendron infortunatum in mammalian organisms.
Chacko T, Menon A, Majeed T, Nair SV, John NS, Nair CKK. Chacko T, et al. J Radiat Res. 2017 May 1;58(3):281-291. doi: 10.1093/jrr/rrw093. J Radiat Res. 2017. PMID: 27864506 Free PMC article.
Oral administration of CIE bestowed a survival advantage to mice exposed to lethal doses of gamma radiation. Radiation-induced depletion of the total blood count and bone marrow cellularity were prevented by treatment with CIE. ...Thus, our results suggest a benefic …
Oral administration of CIE bestowed a survival advantage to mice exposed to lethal doses of gamma radiation. Radiation-induced deplet …
Hepatoprotective activity of Andrographis paniculata and Swertia chirayita.
Nagalekshmi R, Menon A, Chandrasekharan DK, Nair CK. Nagalekshmi R, et al. Food Chem Toxicol. 2011 Dec;49(12):3367-73. doi: 10.1016/j.fct.2011.09.026. Epub 2011 Sep 29. Food Chem Toxicol. 2011. PMID: 21983487
Oral administration of A. paniculata or S. chirayita extract (100-200mg/kg) offered a significant dose dependent protection against paracetamol induced hepatotoxicity as assessed in terms of biochemical and histopathological parameters. ...Thus the present study rev …
Oral administration of A. paniculata or S. chirayita extract (100-200mg/kg) offered a significant dose dependent protection ag …
Allelic losses on chromosomes 14, 10, and 1 in atypical and malignant meningiomas: a genetic model of meningioma progression.
Simon M, von Deimling A, Larson JJ, Wellenreuther R, Kaskel P, Waha A, Warnick RE, Tew JM Jr, Menon AG. Simon M, et al. Cancer Res. 1995 Oct 15;55(20):4696-701. Cancer Res. 1995. PMID: 7553651
To investigate chromosomal events that underlie formation and progression of meningiomas, we have examined a set of 18 benign (WHO grade I), 15 atypical (grade II), and 13 anaplastic/malignant (grade III) meningiomas for loss of heterozygosity (LOH) on chromosomes 1p, 6p, …
To investigate chromosomal events that underlie formation and progression of meningiomas, we have examined a set of 18 benign (WHO gr …
Reduction of Gamma Radiation-Induced Damage by Hydro-Alcoholic Extract of Nardostachys jatamansi.
Menon A, Chacko T, Nair PR, Majeed T, Nair CKK. Menon A, et al. J Environ Pathol Toxicol Oncol. 2019;38(1):83-96. doi: 10.1615/JEnvironPatholToxicolOncol.2019015395. J Environ Pathol Toxicol Oncol. 2019. PMID: 30806293
Molecular-level analysis in the intestines of mice revealed a lower bax/bcl2 ratio suggestive of a reduction of radiation-induced apoptosis. ...The extract also provided a survival advantage to mice exposed to lethal doses of gamma radiation. These results su …
Molecular-level analysis in the intestines of mice revealed a lower bax/bcl2 ratio suggestive of a reduction of radiation-indu …
Loci associated with malignant progression in astrocytomas: a candidate on chromosome 19q.
von Deimling A, Bender B, Jahnke R, Waha A, Kraus J, Albrecht S, Wellenreuther R, Fassbender F, Nagel J, Menon AG, et al. von Deimling A, et al. Cancer Res. 1994 Mar 15;54(6):1397-401. Cancer Res. 1994. PMID: 8137236
LOH on 9p was seen in 1 of 18 (6%) informative cases of A II and 4 of 24 (17%) informative cases of A III. LOH on 17p was observed in 9 of 17 (53%) informative cases of A II and 15 of 26 (58%) informative cases of A III. ...Amplification of the epiderm …
LOH on 9p was seen in 1 of 18 (6%) informative cases of A II and 4 of 24 (17%) informative cases of A III. LOH on 17p was obse …
Role of genomic instability in meningioma progression.
Simon M, Kokkino AJ, Warnick RE, Tew JM Jr, von Deimling A, Menon AG. Simon M, et al. Genes Chromosomes Cancer. 1996 Aug;16(4):265-9. doi: 10.1002/(SICI)1098-2264(199608)16:4<265::AID-GCC7>3.0.CO;2-W. Genes Chromosomes Cancer. 1996. PMID: 8875241
Microsatellite length instability, probably resulting from defective DNA mismatch repair mechanisms, has been described in a variety of cancers. ...Our results argue against a significant role for a generalized microsatellite instability phenotype in meningio …
Microsatellite length instability, probably resulting from defective DNA mismatch repair mechanisms, has been described in a variety …
Clonality of multiple meningiomas.
Stangl AP, Wellenreuther R, Lenartz D, Kraus JA, Menon AG, Schramm J, Wiestler OD, von Deimling A. Stangl AP, et al. J Neurosurg. 1997 May;86(5):853-8. doi: 10.3171/jns.1997.86.5.0853. J Neurosurg. 1997. PMID: 9126902
No patient in our series had a family history of meningiomas or NF2. All tumors were investigated by single-strand conformation polymorphism analysis of the entire coding region of the NF2 gene and by direct DNA sequencing of altered fragments. ...Analysis of constitutiona …
No patient in our series had a family history of meningiomas or NF2. All tumors were investigated by single-strand conformation polym …
Clonal origin of recurrent meningiomas.
von Deimling A, Larson J, Wellenreuther R, Stangl AP, van Velthoven V, Warnick R, Tew J Jr, Balko G, Menon AG. von Deimling A, et al. Brain Pathol. 1999 Oct;9(4):645-50. doi: 10.1111/j.1750-3639.1999.tb00546.x. Brain Pathol. 1999. PMID: 10517503
In order to address the question of clonality in recurring meningiomas, we examined a series of five patients with a total of 14 tumors for X-chromosome inactivation in the tumor tissues. ...This finding suggests a common molecular pathogenesis of primary men …
In order to address the question of clonality in recurring meningiomas, we examined a series of five patients with a total of …
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