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Small molecules intercept Notch signaling and the early secretory pathway.
Krämer A, Mentrup T, Kleizen B, Rivera-Milla E, Reichenbach D, Enzensperger C, Nohl R, Täuscher E, Görls H, Ploubidou A, Englert C, Werz O, Arndt HD, Kaether C. Krämer A, et al. Among authors: mentrup t. Nat Chem Biol. 2013 Nov;9(11):731-8. doi: 10.1038/nchembio.1356. Epub 2013 Sep 29. Nat Chem Biol. 2013. PMID: 24077179
Phagosomal signalling of the C-type lectin receptor Dectin-1 is terminated by intramembrane proteolysis.
Mentrup T, Stumpff-Niggemann AY, Leinung N, Schlosser C, Schubert K, Wehner R, Tunger A, Schatz V, Neubert P, Gradtke AC, Wolf J, Rose-John S, Saftig P, Dalpke A, Jantsch J, Schmitz M, Fluhrer R, Jacobsen ID, Schröder B. Mentrup T, et al. Nat Commun. 2022 Apr 6;13(1):1880. doi: 10.1038/s41467-022-29474-3. Nat Commun. 2022. PMID: 35388002 Free PMC article.
Physiological functions of SPP/SPPL intramembrane proteases.
Mentrup T, Cabrera-Cabrera F, Fluhrer R, Schröder B. Mentrup T, et al. Cell Mol Life Sci. 2020 Aug;77(15):2959-2979. doi: 10.1007/s00018-020-03470-6. Epub 2020 Feb 12. Cell Mol Life Sci. 2020. PMID: 32052089 Free PMC article. Review.
Atherogenic LOX-1 signaling is controlled by SPPL2-mediated intramembrane proteolysis.
Mentrup T, Theodorou K, Cabrera-Cabrera F, Helbig AO, Happ K, Gijbels M, Gradtke AC, Rabe B, Fukumori A, Steiner H, Tholey A, Fluhrer R, Donners M, Schröder B. Mentrup T, et al. J Exp Med. 2019 Apr 1;216(4):807-830. doi: 10.1084/jem.20171438. Epub 2019 Feb 28. J Exp Med. 2019. PMID: 30819724 Free PMC article.
Intramembrane proteases protect from atherosclerosis.
Mentrup T, Schröder B. Mentrup T, et al. Aging (Albany NY). 2019 Oct 4;11(19):8041-8043. doi: 10.18632/aging.102342. Epub 2019 Oct 4. Aging (Albany NY). 2019. PMID: 31584876 Free PMC article. No abstract available.
27 results