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WAF1, a potential mediator of p53 tumor suppression.
el-Deiry WS, Tokino T, Velculescu VE, Levy DB, Parsons R, Trent JM, Lin D, Mercer WE, Kinzler KW, Vogelstein B. el-Deiry WS, et al. Among authors: mercer we. Cell. 1993 Nov 19;75(4):817-25. doi: 10.1016/0092-8674(93)90500-p. Cell. 1993. PMID: 8242752
Using a subtractive hybridization approach, we identified a gene, named WAF1, whose induction was associated with wild-type but not mutant p53 gene expression in a human brain tumor cell line. ...
Using a subtractive hybridization approach, we identified a gene, named WAF1, whose induction was associated with wild-type but not m …
Wip1, a novel human protein phosphatase that is induced in response to ionizing radiation in a p53-dependent manner.
Fiscella M, Zhang H, Fan S, Sakaguchi K, Shen S, Mercer WE, Vande Woude GF, O'Connor PM, Appella E. Fiscella M, et al. Among authors: mercer we. Proc Natl Acad Sci U S A. 1997 Jun 10;94(12):6048-53. doi: 10.1073/pnas.94.12.6048. Proc Natl Acad Sci U S A. 1997. PMID: 9177166 Free PMC article.
Induction of WAF1/CIP1 by a p53-independent pathway.
Michieli P, Chedid M, Lin D, Pierce JH, Mercer WE, Givol D. Michieli P, et al. Among authors: mercer we. Cancer Res. 1994 Jul 1;54(13):3391-5. Cancer Res. 1994. PMID: 8012956
In the present study, we used embryonic fibroblasts from p53 "knock-out" mice to demonstrate p53-independent induction of WAF1/CIP1. We show that serum or individual growth factors such as platelet-derived growth factor, fibroblast growth factor, and epidermal growt …
In the present study, we used embryonic fibroblasts from p53 "knock-out" mice to demonstrate p53-independent induction of WAF1/CIP1. …
The carboxy-terminal serine 392 phosphorylation site of human p53 is not required for wild-type activities.
Fiscella M, Zambrano N, Ullrich SJ, Unger T, Lin D, Cho B, Mercer WE, Anderson CW, Appella E. Fiscella M, et al. Among authors: mercer we. Oncogene. 1994 Nov;9(11):3249-57. Oncogene. 1994. PMID: 7936649
We constructed mutants that changed serine 392 of human p53 to alanine (p53-S392A) or aspartic acid (p53-S392D); cotransfection of both these mutants with a reporter gene carrying a p53-responsive element into the p53-null Saos-2 cell line activated transcription as well a
We constructed mutants that changed serine 392 of human p53 to alanine (p53-S392A) or aspartic acid (p53-S392D); cotransfection of bo
p53-independent induction of WAF1/CIP1 in human leukemia cells is correlated with growth arrest accompanying monocyte/macrophage differentiation.
Zhang W, Grasso L, McClain CD, Gambel AM, Cha Y, Travali S, Deisseroth AB, Mercer WE. Zhang W, et al. Among authors: mercer we. Cancer Res. 1995 Feb 1;55(3):668-74. Cancer Res. 1995. PMID: 7834638
We examined expression of the WAF1/CIP1 gene and its relationship to growth arrest and differentiation in p53-null human leukemic cell lines. We show that p53-independent induction of WAF1/CIP1 occurs in human leukemia cells treated with 12-O-tetradecanoylphorbol-13
We examined expression of the WAF1/CIP1 gene and its relationship to growth arrest and differentiation in p53-null human leukemic cel
Human wild-type p53 adopts a unique conformational and phosphorylation state in vivo during growth arrest of glioblastoma cells.
Ullrich SJ, Mercer WE, Appella E. Ullrich SJ, et al. Among authors: mercer we. Oncogene. 1992 Aug;7(8):1635-43. Oncogene. 1992. PMID: 1630823
The p53 tumor suppressor protein, a modulator of cell proliferation.
Ullrich SJ, Anderson CW, Mercer WE, Appella E. Ullrich SJ, et al. Among authors: mercer we. J Biol Chem. 1992 Aug 5;267(22):15259-62. J Biol Chem. 1992. PMID: 1639769 Review. No abstract available.
Negative growth regulation in a glioblastoma tumor cell line that conditionally expresses human wild-type p53.
Mercer WE, Shields MT, Amin M, Sauve GJ, Appella E, Romano JW, Ullrich SJ. Mercer WE, et al. Proc Natl Acad Sci U S A. 1990 Aug;87(16):6166-70. doi: 10.1073/pnas.87.16.6166. Proc Natl Acad Sci U S A. 1990. PMID: 2143581 Free PMC article.
To investigate the effect that human wild-type p53 (wt-p53) expression has on cell proliferation we constructed a recombinant plasmid, pM47, in which wt-p53 cDNA is under transcriptional control of the hormone-inducible mouse mammary tumor virus promoter linked to the domi …
To investigate the effect that human wild-type p53 (wt-p53) expression has on cell proliferation we constructed a recombinant plasmid …
Constitutive expression of B-myb can bypass p53-induced Waf1/Cip1-mediated G1 arrest.
Lin D, Fiscella M, O'Connor PM, Jackman J, Chen M, Luo LL, Sala A, Travali S, Appella E, Mercer WE. Lin D, et al. Among authors: mercer we. Proc Natl Acad Sci U S A. 1994 Oct 11;91(21):10079-83. doi: 10.1073/pnas.91.21.10079. Proc Natl Acad Sci U S A. 1994. PMID: 7937841 Free PMC article.
In this study we show that B-myb expression is required for cells to progress from G1 into S phase and that high levels of ectopic B-myb expression uncoupled from cell cycle regulation rescues cells from p53-induced G1 arrest even in the presence of Waf1/Cip1 transactivati …
In this study we show that B-myb expression is required for cells to progress from G1 into S phase and that high levels of ectopic B- …
Growth factor regulated expression of poly(A)+ binding protein messenger RNA.
Mercer WE, Jaskulski D, Shields MT. Mercer WE, et al. Exp Cell Res. 1989 Apr;181(2):531-41. doi: 10.1016/0014-4827(89)90109-2. Exp Cell Res. 1989. PMID: 2647498
We have employed a human PABP cDNA probe to study the expression of this gene at the mRNA level in BALB/c3T3 mouse cells under different growth conditions and in exponentially growing HeLa cells throughout the cell division cycle. We describe experiments which estab
We have employed a human PABP cDNA probe to study the expression of this gene at the mRNA level in BALB/c3T3 mouse cells under differ
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