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The gamma-secretase inhibitor N-[N-(3,5-difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester reduces A beta levels in vivo in plasma and cerebrospinal fluid in young (plaque-free) and aged (plaque-bearing) Tg2576 mice.
Lanz TA, Himes CS, Pallante G, Adams L, Yamazaki S, Amore B, Merchant KM. Lanz TA, et al. Among authors: merchant km. J Pharmacol Exp Ther. 2003 Jun;305(3):864-71. doi: 10.1124/jpet.102.048280. Epub 2003 Mar 6. J Pharmacol Exp Ther. 2003. PMID: 12626636
Studies of Abeta pharmacodynamics in the brain, cerebrospinal fluid, and plasma in young (plaque-free) Tg2576 mice using the gamma-secretase inhibitor N2-[(2S)-2-(3,5-difluorophenyl)-2-hydroxyethanoyl]-N1-[(7S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl]-L-alaninamide (LY-411575).
Lanz TA, Hosley JD, Adams WJ, Merchant KM. Lanz TA, et al. Among authors: merchant km. J Pharmacol Exp Ther. 2004 Apr;309(1):49-55. doi: 10.1124/jpet.103.060715. Epub 2004 Jan 12. J Pharmacol Exp Ther. 2004. PMID: 14718585
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