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101 results
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The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics.
Karran E, Mercken M, De Strooper B. Karran E, et al. Among authors: mercken m. Nat Rev Drug Discov. 2011 Aug 19;10(9):698-712. doi: 10.1038/nrd3505. Nat Rev Drug Discov. 2011. PMID: 21852788 Review.
Design and synthesis of bicyclic heterocycles as potent γ-secretase modulators.
Oehlrich D, Rombouts FJ, Berthelot D, Bischoff FP, De Cleyn MA, Jaroskova L, Macdonald G, Mercken M, Surkyn M, Trabanco AA, Tresadern G, Van Brandt S, Velter AI, Wu T, Gijsen HJ. Oehlrich D, et al. Among authors: mercken m. Bioorg Med Chem Lett. 2013 Sep 1;23(17):4794-800. doi: 10.1016/j.bmcl.2013.06.100. Epub 2013 Jul 11. Bioorg Med Chem Lett. 2013. PMID: 23890837
Synthesis and Evaluation of a Zr-89-Labeled Monoclonal Antibody for Immuno-PET Imaging of Amyloid-β Deposition in the Brain.
Fissers J, Waldron AM, De Vijlder T, Van Broeck B, Pemberton DJ, Mercken M, Van Der Veken P, Joossens J, Augustyns K, Dedeurwaerdere S, Stroobants S, Staelens S, Wyffels L. Fissers J, et al. Among authors: mercken m. Mol Imaging Biol. 2016 Aug;18(4):598-605. doi: 10.1007/s11307-016-0935-z. Mol Imaging Biol. 2016. PMID: 26846128
BACE1 Dynamics Upon Inhibition with a BACE Inhibitor and Correlation to Downstream Alzheimer's Disease Markers in Elderly Healthy Participants.
Timmers M, Barão S, Van Broeck B, Tesseur I, Slemmon J, De Waepenaert K, Bogert J, Shaw LM, Engelborghs S, Moechars D, Mercken M, Van Nueten L, Tritsmans L, de Strooper B, Streffer JR. Timmers M, et al. Among authors: mercken m. J Alzheimers Dis. 2017;56(4):1437-1449. doi: 10.3233/JAD-160829. J Alzheimers Dis. 2017. PMID: 28157093 Free PMC article. Clinical Trial.
Anilinotriazoles as potent gamma secretase modulators.
Velter AI, Bischoff FP, Berthelot D, De Cleyn M, Oehlrich D, Jaroskova L, Macdonald G, Minne G, Pieters S, Rombouts F, Van Brandt S, Van Roosbroeck Y, Surkyn M, Trabanco AA, Tresadern G, Wu T, Borghys H, Mercken M, Masungi C, Gijsen H. Velter AI, et al. Among authors: mercken m. Bioorg Med Chem Lett. 2014 Dec 15;24(24):5805-5813. doi: 10.1016/j.bmcl.2014.10.024. Epub 2014 Oct 18. Bioorg Med Chem Lett. 2014. PMID: 25454273
Comparison of two different methods for measurement of amyloid-β peptides in cerebrospinal fluid after BACE1 inhibition in a dog model.
Borghys H, Jacobs T, Van Broeck B, Dillen L, Dhuyvetter D, Gijsen H, Mercken M. Borghys H, et al. Among authors: mercken m. J Alzheimers Dis. 2014;38(1):39-48. doi: 10.3233/JAD-130599. J Alzheimers Dis. 2014. PMID: 23948925
Method for the determination of the levels of beta-amyloid peptide in the CSF sampled from freely moving rats.
El Mouedden M, Haseldonckx M, Mackie C, Meert T, Mercken M. El Mouedden M, et al. Among authors: mercken m. J Pharmacol Toxicol Methods. 2005 Sep-Oct;52(2):229-33. doi: 10.1016/j.vascn.2005.02.002. Epub 2005 Apr 14. J Pharmacol Toxicol Methods. 2005. PMID: 16125620
Reduction of Abeta levels in the Sprague Dawley rat after oral administration of the functional gamma-secretase inhibitor, DAPT: a novel non-transgenic model for Abeta production inhibitors.
El Mouedden M, Vandermeeren M, Meert T, Mercken M. El Mouedden M, et al. Among authors: mercken m. Curr Pharm Des. 2006;12(6):671-6. doi: 10.2174/138161206775474233. Curr Pharm Des. 2006. PMID: 16472156
Alzheimer's-Causing Mutations Shift Aβ Length by Destabilizing γ-Secretase-Aβn Interactions.
Szaruga M, Munteanu B, Lismont S, Veugelen S, Horré K, Mercken M, Saido TC, Ryan NS, De Vos T, Savvides SN, Gallardo R, Schymkowitz J, Rousseau F, Fox NC, Hopf C, De Strooper B, Chávez-Gutiérrez L. Szaruga M, et al. Among authors: mercken m. Cell. 2017 Jul 27;170(3):443-456.e14. doi: 10.1016/j.cell.2017.07.004. Cell. 2017. PMID: 28753424
Comment on "ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficits in AD mouse models".
Tesseur I, Lo AC, Roberfroid A, Dietvorst S, Van Broeck B, Borgers M, Gijsen H, Moechars D, Mercken M, Kemp J, D'Hooge R, De Strooper B. Tesseur I, et al. Among authors: mercken m. Science. 2013 May 24;340(6135):924-e. doi: 10.1126/science.1233937. Science. 2013. PMID: 23704554
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