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14 results
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A Cdk7-Cdk4 T-loop phosphorylation cascade promotes G1 progression.
Schachter MM, Merrick KA, Larochelle S, Hirschi A, Zhang C, Shokat KM, Rubin SM, Fisher RP. Schachter MM, et al. Among authors: merrick ka. Mol Cell. 2013 Apr 25;50(2):250-60. doi: 10.1016/j.molcel.2013.04.003. Mol Cell. 2013. PMID: 23622515 Free PMC article.
Chemical genetics reveals a specific requirement for Cdk2 activity in the DNA damage response and identifies Nbs1 as a Cdk2 substrate in human cells.
Wohlbold L, Merrick KA, De S, Amat R, Kim JH, Larochelle S, Allen JJ, Zhang C, Shokat KM, Petrini JH, Fisher RP. Wohlbold L, et al. Among authors: merrick ka. PLoS Genet. 2012 Aug;8(8):e1002935. doi: 10.1371/journal.pgen.1002935. Epub 2012 Aug 23. PLoS Genet. 2012. PMID: 22927831 Free PMC article.
Switching Cdk2 on or off with small molecules to reveal requirements in human cell proliferation.
Merrick KA, Wohlbold L, Zhang C, Allen JJ, Horiuchi D, Huskey NE, Goga A, Shokat KM, Fisher RP. Merrick KA, et al. Mol Cell. 2011 Jun 10;42(5):624-36. doi: 10.1016/j.molcel.2011.03.031. Mol Cell. 2011. PMID: 21658603 Free PMC article.
Requirements for Cdk7 in the assembly of Cdk1/cyclin B and activation of Cdk2 revealed by chemical genetics in human cells.
Larochelle S, Merrick KA, Terret ME, Wohlbold L, Barboza NM, Zhang C, Shokat KM, Jallepalli PV, Fisher RP. Larochelle S, et al. Mol Cell. 2007 Mar 23;25(6):839-50. doi: 10.1016/j.molcel.2007.02.003. Mol Cell. 2007. PMID: 17386261 Free PMC article.
Chemical-genetic analysis of cyclin dependent kinase 2 function reveals an important role in cellular transformation by multiple oncogenic pathways.
Horiuchi D, Huskey NE, Kusdra L, Wohlbold L, Merrick KA, Zhang C, Creasman KJ, Shokat KM, Fisher RP, Goga A. Horiuchi D, et al. Among authors: merrick ka. Proc Natl Acad Sci U S A. 2012 Apr 24;109(17):E1019-27. doi: 10.1073/pnas.1111317109. Epub 2012 Apr 3. Proc Natl Acad Sci U S A. 2012. PMID: 22474407 Free PMC article.
A Pleiotropic RNA-Binding Protein Controls Distinct Cell Cycle Checkpoints to Drive Resistance of p53-Defective Tumors to Chemotherapy.
Cannell IG, Merrick KA, Morandell S, Zhu CQ, Braun CJ, Grant RA, Cameron ER, Tsao MS, Hemann MT, Yaffe MB. Cannell IG, et al. Among authors: merrick ka. Cancer Cell. 2015 Nov 9;28(5):623-637. doi: 10.1016/j.ccell.2015.09.009. Cancer Cell. 2015. PMID: 26602816 Free PMC article.
Design of a brain-penetrant CDK4/6 inhibitor for glioblastoma.
Bronner SM, Merrick KA, Murray J, Salphati L, Moffat JG, Pang J, Sneeringer CJ, Dompe N, Cyr P, Purkey H, Boenig GL, Li J, Kolesnikov A, Larouche-Gauthier R, Lai KW, Shen X, Aubert-Nicol S, Chen YC, Cheong J, Crawford JJ, Hafner M, Haghshenas P, Jakalian A, Leclerc JP, Lim NK, O'Brien T, Plise EG, Shalan H, Sturino C, Wai J, Xiao Y, Yin J, Zhao L, Gould S, Olivero A, Heffron TP. Bronner SM, et al. Among authors: merrick ka. Bioorg Med Chem Lett. 2019 Aug 15;29(16):2294-2301. doi: 10.1016/j.bmcl.2019.06.021. Epub 2019 Jun 26. Bioorg Med Chem Lett. 2019. PMID: 31307887
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