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The bromodomain: from epigenome reader to druggable target.
Sanchez R, Meslamani J, Zhou MM. Sanchez R, et al. Among authors: meslamani j. Biochim Biophys Acta. 2014 Aug;1839(8):676-85. doi: 10.1016/j.bbagrm.2014.03.011. Epub 2014 Mar 28. Biochim Biophys Acta. 2014. PMID: 24686119 Free PMC article. Review.
Structural features and inhibitors of bromodomains.
Meslamani J, Smith SG, Sanchez R, Zhou MM. Meslamani J, et al. Drug Discov Today Technol. 2016 Mar;19:3-15. doi: 10.1016/j.ddtec.2016.09.001. Epub 2016 Sep 22. Drug Discov Today Technol. 2016. PMID: 27769355 Free PMC article. Review.
BET N-terminal bromodomain inhibition selectively blocks Th17 cell differentiation and ameliorates colitis in mice.
Cheung K, Lu G, Sharma R, Vincek A, Zhang R, Plotnikov AN, Zhang F, Zhang Q, Ju Y, Hu Y, Zhao L, Han X, Meslamani J, Xu F, Jaganathan A, Shen T, Zhu H, Rusinova E, Zeng L, Zhou J, Yang J, Peng L, Ohlmeyer M, Walsh MJ, Zhang DY, Xiong H, Zhou MM. Cheung K, et al. Among authors: meslamani j. Proc Natl Acad Sci U S A. 2017 Mar 14;114(11):2952-2957. doi: 10.1073/pnas.1615601114. Epub 2017 Mar 6. Proc Natl Acad Sci U S A. 2017. PMID: 28265070 Free PMC article.
Spatially constrained tandem bromodomain inhibition bolsters sustained repression of BRD4 transcriptional activity for TNBC cell growth.
Ren C, Zhang G, Han F, Fu S, Cao Y, Zhang F, Zhang Q, Meslamani J, Xu Y, Ji D, Cao L, Zhou Q, Cheung KL, Sharma R, Babault N, Yi Z, Zhang W, Walsh MJ, Zeng L, Zhou MM. Ren C, et al. Among authors: meslamani j. Proc Natl Acad Sci U S A. 2018 Jul 31;115(31):7949-7954. doi: 10.1073/pnas.1720000115. Epub 2018 Jul 16. Proc Natl Acad Sci U S A. 2018. PMID: 30012592 Free PMC article.
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