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141 results
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Restoration of first-phase insulin secretion by the imidazoline compound LY374284 in pancreatic islets of diabetic db/db mice.
Brenner MB, Gromada J, Efanov AM, Bokvist K, Mest HJ. Brenner MB, et al. Among authors: mest hj. Ann N Y Acad Sci. 2003 Dec;1009:332-40. doi: 10.1196/annals.1304.042. Ann N Y Acad Sci. 2003. PMID: 15028607
Dipeptidyl peptidase inhibitors as new drugs for the treatment of type 2 diabetes.
Mest HJ, Mentlein R. Mest HJ, et al. Diabetologia. 2005 Apr;48(4):616-20. doi: 10.1007/s00125-005-1707-5. Epub 2005 Mar 16. Diabetologia. 2005. PMID: 15770466
Fused bicyclic Gly-Asp beta-turn mimics with specific affinity for GPIIb-IIIa.
Fisher MJ, Arfstan AE, Giese U, Gunn BP, Harms CS, Khau V, Kinnick MD, Lindstrom TD, Martinelli MJ, Mest HJ, Mohr M, Morin JM Jr, Mullaney JT, Nunes A, Paal M, Rapp A, Rühter G, Ruterbories KJ, Sall DJ, Scarborough RM, Schotten T, Sommer B, Stenzel W, Towner RD, Um SL, et al. Fisher MJ, et al. Among authors: mest hj. J Med Chem. 1999 Nov 18;42(23):4875-89. doi: 10.1021/jm990365y. J Med Chem. 1999. PMID: 10579850
Fused bicyclic Gly-Asp beta-turn mimics with potent affinity for GPIIb-IIIa. Exploration of the arginine isostere.
Fisher MJ, Giese U, Harms CS, Kinnick MD, Lindstrom TD, McCowan JR, Mest HJ, Morin JM Jr, Mullaney JT, Paal M, Rapp A, Rühter G, Ruterbories KJ, Sall DJ, Scarborough RM, Schotten T, Stenzel W, Towner RD, Um SL, Utterback BG, Wyss VL, Jakubowski JA. Fisher MJ, et al. Among authors: mest hj. Bioorg Med Chem Lett. 2000 Feb 21;10(4):385-9. doi: 10.1016/s0960-894x(00)00008-1. Bioorg Med Chem Lett. 2000. PMID: 10714506
Discovery of non-covalent dipeptidyl peptidase IV inhibitors which induce a conformational change in the active site.
Sheehan SM, Mest HJ, Watson BM, Klimkowski VJ, Timm DE, Cauvin A, Parsons SH, Shi Q, Canada EJ, Wiley MR, Ruehter G, Evers B, Petersen S, Blaszczak LC, Pulley SR, Margolis BJ, Wishart GN, Renson B, Hankotius D, Mohr M, Zechel JC, Michael Kalbfleisch J, Dingess-Hammond EA, Boelke A, Weichert AG. Sheehan SM, et al. Among authors: mest hj. Bioorg Med Chem Lett. 2007 Mar 15;17(6):1765-8. doi: 10.1016/j.bmcl.2006.12.074. Epub 2006 Dec 24. Bioorg Med Chem Lett. 2007. PMID: 17239592
Dipeptidyl peptidase-IV inhibitors can restore glucose homeostasis in type 2 diabetics via incretin enhancement.
Mest HJ. Mest HJ. Curr Opin Investig Drugs. 2006 Apr;7(4):338-43. Curr Opin Investig Drugs. 2006. PMID: 16625820 Review.
Structure activity studies of the serine-AIB dipeptide domain in 2,3-dihydroisothiazole based growth hormone secretagogues.
Evers B, Ruehter G, Berg M, Dodge JA, Hankotius D, Hary U, Jungheim LN, Mest HJ, de la Nava EM, Mohr M, Muehl BS, Petersen S, Sommer B, Riedel-Herold G, Tebbe MJ, Thrasher KJ, Voelkers S. Evers B, et al. Among authors: mest hj. Bioorg Med Chem. 2005 Dec 15;13(24):6748-62. doi: 10.1016/j.bmc.2005.07.070. Epub 2005 Oct 10. Bioorg Med Chem. 2005. PMID: 16219466
A buffer temperature controlled perifusion system to study temperature dependence and kinetics of insulin secretion in MIN6 pseudoislets.
Brenner MB, Mest HJ. Brenner MB, et al. Among authors: mest hj. J Pharmacol Toxicol Methods. 2004 Jul-Aug;50(1):53-7. doi: 10.1016/j.vascn.2004.01.002. J Pharmacol Toxicol Methods. 2004. PMID: 15233968
Inhibition of recombinant K(ATP) channels by the antidiabetic agents midaglizole, LY397364 and LY389382.
Proks P, Treinies I, Mest HJ, Trapp S. Proks P, et al. Among authors: mest hj. Eur J Pharmacol. 2002 Sep 27;452(1):11-9. doi: 10.1016/s0014-2999(02)02234-3. Eur J Pharmacol. 2002. PMID: 12323381
Pertussis toxin converts hyperpolarizations caused by alpha(2)-adrenoceptor agonists containing an imidazoline moiety into depolarizations in MIN 6 cells.
Scheltdorf M, Mest HJ. Scheltdorf M, et al. Among authors: mest hj. Naunyn Schmiedebergs Arch Pharmacol. 2002 Sep;366(3):204-8. doi: 10.1007/s00210-002-0612-4. Epub 2002 Jul 5. Naunyn Schmiedebergs Arch Pharmacol. 2002. PMID: 12172702
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