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Page 1
CaMKII as a Therapeutic Target in Cardiovascular Disease.
Reyes Gaido OE, Nkashama LJ, Schole KL, Wang Q, Umapathi P, Mesubi OO, Konstantinidis K, Luczak ED, Anderson ME. Reyes Gaido OE, et al. Among authors: mesubi oo. Annu Rev Pharmacol Toxicol. 2023 Jan 20;63:249-272. doi: 10.1146/annurev-pharmtox-051421-111814. Epub 2022 Aug 16. Annu Rev Pharmacol Toxicol. 2023. PMID: 35973713 Free article. Review.
Excessive O-GlcNAcylation Causes Heart Failure and Sudden Death.
Umapathi P, Mesubi OO, Banerjee PS, Abrol N, Wang Q, Luczak ED, Wu Y, Granger JM, Wei AC, Reyes Gaido OE, Florea L, Talbot CC Jr, Hart GW, Zachara NE, Anderson ME. Umapathi P, et al. Among authors: mesubi oo. Circulation. 2021 Apr 27;143(17):1687-1703. doi: 10.1161/CIRCULATIONAHA.120.051911. Epub 2021 Feb 17. Circulation. 2021. PMID: 33593071 Free PMC article.
An improved reporter identifies ruxolitinib as a potent and cardioprotective CaMKII inhibitor.
Reyes Gaido OE, Pavlaki N, Granger JM, Mesubi OO, Liu B, Lin BL, Long A, Walker D, Mayourian J, Schole KL, Terrillion CE, Nkashama LJ, Hulsurkar MM, Dorn LE, Ferrero KM, Huganir RL, Müller FU, Wehrens XHT, Liu JO, Luczak ED, Bezzerides VJ, Anderson ME. Reyes Gaido OE, et al. Among authors: mesubi oo. Sci Transl Med. 2023 Jun 21;15(701):eabq7839. doi: 10.1126/scitranslmed.abq7839. Epub 2023 Jun 21. Sci Transl Med. 2023. PMID: 37343080
Heart Failure and Atrial Fibrillation-Chicken or Egg?
Mesubi OO, Anderson ME. Mesubi OO, et al. Circ Res. 2022 Apr;130(7):1011-1013. doi: 10.1161/CIRCRESAHA.122.320930. Epub 2022 Mar 31. Circ Res. 2022. PMID: 35357896 No abstract available.
Oxidized CaMKII and O-GlcNAcylation cause increased atrial fibrillation in diabetic mice by distinct mechanisms.
Mesubi OO, Rokita AG, Abrol N, Wu Y, Chen B, Wang Q, Granger JM, Tucker-Bartley A, Luczak ED, Murphy KR, Umapathi P, Banerjee PS, Boronina TN, Cole RN, Maier LS, Wehrens XH, Pomerantz JL, Song LS, Ahima RS, Hart GW, Zachara NE, Anderson ME. Mesubi OO, et al. J Clin Invest. 2021 Jan 19;131(2):e95747. doi: 10.1172/JCI95747. J Clin Invest. 2021. PMID: 33151911 Free PMC article.