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MetaLnc9 facilitates osteogenesis of human bone marrow mesenchymal stem cells by activating the AKT pathway.
Chang S, Zhuang Z, Jin C. Chang S, et al. Connect Tissue Res. 2023 Nov;64(6):532-542. doi: 10.1080/03008207.2023.2232463. Epub 2023 Jul 10. Connect Tissue Res. 2023. PMID: 37427853
AKT pathway activator SC-79 and inhibitor LY294002 were used to validate the relationship between MetaLnc9 and AKT signaling pathway. RESULTS: The expression of MetaLnc9 was significantly upregulated in the osteogenic differentiation of hBMSCs. ...Taking a deeper in …
AKT pathway activator SC-79 and inhibitor LY294002 were used to validate the relationship between MetaLnc9 and AKT signaling pathway. …
Targeting MetaLnc9/miR-143/FSCN1 axis inhibits oxidative stress and myofibroblast transdifferentiation in oral submucous fibrosis.
Lu MY, Hsieh PL, Chao SC, Fang CY, Ohiro Y, Liao YW, Yu CC, Chang MT. Lu MY, et al. J Dent Sci. 2024 Jul;19(3):1416-1425. doi: 10.1016/j.jds.2024.04.008. Epub 2024 Apr 23. J Dent Sci. 2024. PMID: 39035266 Free PMC article.
Silencing of MetaLnc9 diminished the features of activated myofibroblasts and the production of ROS. We not only showed that MetaLnc9 functioned as a competitive endogenous RNA of microRNA (miR)-143, but also demonstrated that the pro-fibrosis effect of MetaLnc9
Silencing of MetaLnc9 diminished the features of activated myofibroblasts and the production of ROS. We not only showed that MetaL
MetaLnc9 Facilitates Lung Cancer Metastasis via a PGK1-Activated AKT/mTOR Pathway.
Yu T, Zhao Y, Hu Z, Li J, Chu D, Zhang J, Li Z, Chen B, Zhang X, Pan H, Li S, Lin H, Liu L, Yan M, He X, Yao M. Yu T, et al. Cancer Res. 2017 Nov 1;77(21):5782-5794. doi: 10.1158/0008-5472.CAN-17-0671. Epub 2017 Sep 18. Cancer Res. 2017. PMID: 28923857
MetaLnc9 also interacted with P54nrb/NonO (NONO) to help mediate the activity of CRTC, a coactivator for the transcription factor CREB, reinforcing a positive feedback loop for metastasis. Taken together, our results establish MetaLnc9 as a driver of metastasis and
MetaLnc9 also interacted with P54nrb/NonO (NONO) to help mediate the activity of CRTC, a coactivator for the transcription factor CRE
MetaLnc9-Antisense RNA Contributes to Lung Cancer Metastasis via Modulating RNA-RNA Duplex with MetaLnc9.
Yu T, Lin K, Pan H, Sun L, Zhu Y. Yu T, et al. DNA Cell Biol. 2022 Apr;41(4):390-399. doi: 10.1089/dna.2021.1088. Epub 2022 Mar 25. DNA Cell Biol. 2022. PMID: 35333617
Here, we identified an antisense lncRNA, MetaLnc9 antisense (Metalnc9-AS), which arises from the antisense strand of Metalnc9, located on chr9q34.11, while its biological function and mechanism are not clear in lung cancer. ...The gain of MetaLnc9-AS w …
Here, we identified an antisense lncRNA, MetaLnc9 antisense (Metalnc9-AS), which arises from the antisense strand of Metaln