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3,493 results

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Page 1
Metastatic uveal melanoma: The final frontier.
Rantala ES, Hernberg MM, Piperno-Neumann S, Grossniklaus HE, Kivelä TT. Rantala ES, et al. Prog Retin Eye Res. 2022 Sep;90:101041. doi: 10.1016/j.preteyeres.2022.101041. Epub 2022 Jan 6. Prog Retin Eye Res. 2022. PMID: 34999237 Free article. Review.
The final frontier in conquering uveal melanoma lies in solving these issues to cure metastatic disease. Most studies on metastatic uveal melanoma are small, uncontrolled, retrospective, and do not report staging. ...Promoting dormancy of …
The final frontier in conquering uveal melanoma lies in solving these issues to cure metastatic disease. Most studies o …
Three-Year Overall Survival with Tebentafusp in Metastatic Uveal Melanoma.
Hassel JC, Piperno-Neumann S, Rutkowski P, Baurain JF, Schlaak M, Butler MO, Sullivan RJ, Dummer R, Kirkwood JM, Orloff M, Sacco JJ, Ochsenreither S, Joshua AM, Gastaud L, Curti B, Piulats JM, Salama AKS, Shoushtari AN, Demidov L, Milhem M, Chmielowski B, Kim KB, Carvajal RD, Hamid O, Collins L, Ranade K, Holland C, Pfeiffer C, Nathan P. Hassel JC, et al. N Engl J Med. 2023 Dec 14;389(24):2256-2266. doi: 10.1056/NEJMoa2304753. Epub 2023 Oct 21. N Engl J Med. 2023. PMID: 37870955 Free PMC article. Clinical Trial.
BACKGROUND: Tebentafusp, a T-cell receptor-bispecific molecule that targets glycoprotein 100 and CD3, is approved for adult patients who are positive for HLA-A*02:01 and have unresectable or metastatic uveal melanoma. The primary analysis in the present phase …
BACKGROUND: Tebentafusp, a T-cell receptor-bispecific molecule that targets glycoprotein 100 and CD3, is approved for adult patients who are …
Single-cell hdWGCNA reveals metastatic protective macrophages and development of deep learning model in uveal melanoma.
Sun Y, Wu J, Zhang Q, Wang P, Zhang J, Yuan Y. Sun Y, et al. J Transl Med. 2024 Jul 29;22(1):695. doi: 10.1186/s12967-024-05421-2. J Transl Med. 2024. PMID: 39075441 Free PMC article.
BACKGROUND: Although there has been some progress in the treatment of primary uveal melanoma (UVM), distant metastasis remains the leading cause of death in patients. ...Machine learning models were developed using the identified metastatic protective macroph …
BACKGROUND: Although there has been some progress in the treatment of primary uveal melanoma (UVM), distant metastasis remains …
Uveal melanoma: From diagnosis to treatment and the science in between.
Chattopadhyay C, Kim DW, Gombos DS, Oba J, Qin Y, Williams MD, Esmaeli B, Grimm EA, Wargo JA, Woodman SE, Patel SP. Chattopadhyay C, et al. Cancer. 2016 Aug 1;122(15):2299-312. doi: 10.1002/cncr.29727. Epub 2016 Mar 15. Cancer. 2016. PMID: 26991400 Free PMC article. Review.
Once uveal melanoma becomes metastatic, therapy options are limited and are often extrapolated from cutaneous melanoma therapies despite the routine exclusion of patients with uveal melanoma from clinical trials. Clinical trials directed …
Once uveal melanoma becomes metastatic, therapy options are limited and are often extrapolated from cutaneous melano …
Uveal melanoma: In the era of new treatments.
Wespiser M, Neidhardt E, Negrier S. Wespiser M, et al. Cancer Treat Rev. 2023 Sep;119:102599. doi: 10.1016/j.ctrv.2023.102599. Epub 2023 Jul 7. Cancer Treat Rev. 2023. PMID: 37473516 Review.
Uveal melanoma (UM), also known as choroidal melanoma, is the leading adult intraocular tumor worldwide, affecting mainly Caucasian populations. ...Despite optimal management, half of the patients will become metastatic, with liver involvement i …
Uveal melanoma (UM), also known as choroidal melanoma, is the leading adult intraocular tumor worldwide, affecti …
Metastatic lesion of a choroidal melanoma located in the head of pancreas.
Castro Rodríguez J, Osuna Soto J, Perdices López EV. Castro Rodríguez J, et al. Rev Esp Enferm Dig. 2023 May;115(5):261-263. doi: 10.17235/reed.2022.8843/2022. Rev Esp Enferm Dig. 2023. PMID: 35545916 Free article.
Metastases in pancreas are uncommon, ranging from 2 to 5 % of pancreatic malignancies. Choroidal melanoma is rare, and less than 1% spread to the pancreas. It can cause obstructive jaundice if it affects the pancreatic head region. ...
Metastases in pancreas are uncommon, ranging from 2 to 5 % of pancreatic malignancies. Choroidal melanoma is rare, and less th …
Efficacy and Safety of the Melphalan/Hepatic Delivery System in Patients with Unresectable Metastatic Uveal Melanoma: Results from an Open-Label, Single-Arm, Multicenter Phase 3 Study.
Zager JS, Orloff M, Ferrucci PF, Choi J, Eschelman DJ, Glazer ES, Ejaz A, Howard JH, Richtig E, Ochsenreither S, Reddy SA, Lowe MC, Beasley GM, Gesierich A, Bender A, Gschnell M, Dummer R, Rivoire M, Arance A, Fenwick SW, Sacco JJ, Haferkamp S, Weishaupt C, John J, Wheater M, Ottensmeier CH. Zager JS, et al. Ann Surg Oncol. 2024 Aug;31(8):5340-5351. doi: 10.1245/s10434-024-15293-x. Epub 2024 May 4. Ann Surg Oncol. 2024. PMID: 38704501 Free PMC article. Clinical Trial.
BACKGROUND: Uveal melanoma (UM) has a poor prognosis once liver metastases occur. The melphalan/Hepatic Delivery System (melphalan/HDS) is a drug/device combination used for liver-directed treatment of metastatic UM (mUM) patients. ...The primary end point wa …
BACKGROUND: Uveal melanoma (UM) has a poor prognosis once liver metastases occur. The melphalan/Hepatic Delivery System (melph …
Tebentafusp: First Approval.
Dhillon S. Dhillon S. Drugs. 2022 Apr;82(6):703-710. doi: 10.1007/s40265-022-01704-4. Drugs. 2022. PMID: 35364798 Review.
Tebentafusp is under regulatory review for the treatment of metastatic uveal melanoma in the UK, Australia and Canada. Clinical studies of tebentafusp are underway for uveal melanoma and cutaneous melanoma in several countries worldwide. …
Tebentafusp is under regulatory review for the treatment of metastatic uveal melanoma in the UK, Australia and Canada. …
Novel treatment paradigms for metastatic uveal melanoma.
Patel SP, Katz SC. Patel SP, et al. Cancer Gene Ther. 2022 Dec;29(12):1807-1808. doi: 10.1038/s41417-022-00558-y. Epub 2022 Dec 1. Cancer Gene Ther. 2022. PMID: 36456705 Free PMC article. No abstract available.
LXS196 for Metastatic Uveal Melanoma - finally some progress.
Rodrigues A, Cosman R, Joshua AM. Rodrigues A, et al. Br J Cancer. 2023 May;128(10):1791-1793. doi: 10.1038/s41416-023-02199-w. Epub 2023 Mar 1. Br J Cancer. 2023. PMID: 36859685 Free PMC article.
Metastatic uveal melanoma continues to have a poor prognosis with distinct pathophysiology from cutaneous melanoma and limited effective treatment options. ...
Metastatic uveal melanoma continues to have a poor prognosis with distinct pathophysiology from cutaneous melanoma …
3,493 results