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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1962 3
1963 9
1964 11
1965 3
1966 2
1967 1
1968 9
1969 7
1970 4
1971 12
1972 13
1973 5
1974 2
1975 5
1976 16
1977 20
1978 22
1979 25
1980 18
1981 14
1982 8
1983 22
1984 23
1985 14
1986 16
1987 26
1988 23
1989 27
1990 24
1991 45
1992 37
1993 42
1994 43
1995 67
1996 82
1997 90
1998 126
1999 161
2000 171
2001 183
2002 271
2003 318
2004 366
2005 421
2006 525
2007 572
2008 644
2009 721
2010 886
2011 1015
2012 1180
2013 1340
2014 1640
2015 1776
2016 1885
2017 2003
2018 2131
2019 2242
2020 2653
2021 2867
2022 2689
2023 1213

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27,470 results

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Page 1
Metformin as Anti-Aging Therapy: Is It for Everyone?
Soukas AA, Hao H, Wu L. Soukas AA, et al. Trends Endocrinol Metab. 2019 Oct;30(10):745-755. doi: 10.1016/j.tem.2019.07.015. Epub 2019 Aug 9. Trends Endocrinol Metab. 2019. PMID: 31405774 Free PMC article. Review.
Metformin is the most widely prescribed oral hypoglycemic medication for type 2 diabetes worldwide. ...This review provides an overview of recent findings from metformin studies in aging and longevity and discusses the use of metformin to combat aging and agi …
Metformin is the most widely prescribed oral hypoglycemic medication for type 2 diabetes worldwide. ...This review provides an overvi …
Low-dose metformin targets the lysosomal AMPK pathway through PEN2.
Ma T, Tian X, Zhang B, Li M, Wang Y, Yang C, Wu J, Wei X, Qu Q, Yu Y, Long S, Feng JW, Li C, Zhang C, Xie C, Wu Y, Xu Z, Chen J, Yu Y, Huang X, He Y, Yao L, Zhang L, Zhu M, Wang W, Wang ZC, Zhang M, Bao Y, Jia W, Lin SY, Ye Z, Piao HL, Deng X, Zhang CS, Lin SC. Ma T, et al. Nature. 2022 Mar;603(7899):159-165. doi: 10.1038/s41586-022-04431-8. Epub 2022 Feb 23. Nature. 2022. PMID: 35197629 Free PMC article.
For clinical doses of metformin, AMP-activated protein kinase (AMPK) has a major role in its mechanism of action(4,5); however, the direct molecular target of metformin remains unknown. ...We synthesize a photoactive metformin probe and identify PEN2, a subun …
For clinical doses of metformin, AMP-activated protein kinase (AMPK) has a major role in its mechanism of action(4,5); however, the d …
Metformin: Is it a drug for all reasons and diseases?
Triggle CR, Mohammed I, Bshesh K, Marei I, Ye K, Ding H, MacDonald R, Hollenberg MD, Hill MA. Triggle CR, et al. Metabolism. 2022 Aug;133:155223. doi: 10.1016/j.metabol.2022.155223. Epub 2022 May 29. Metabolism. 2022. PMID: 35640743 Free article. Review.
In type 1 diabetes metformin may help reduce the insulin dose. Meta-analysis and data from pre-clinical and clinical studies link metformin to a reduction in the incidence of cancer. Clinical trials, including MILES (Metformin In Longevity Study), and TAME (T …
In type 1 diabetes metformin may help reduce the insulin dose. Meta-analysis and data from pre-clinical and clinical studies link …
Benefits of Metformin in Attenuating the Hallmarks of Aging.
Kulkarni AS, Gubbi S, Barzilai N. Kulkarni AS, et al. Cell Metab. 2020 Jul 7;32(1):15-30. doi: 10.1016/j.cmet.2020.04.001. Epub 2020 Apr 24. Cell Metab. 2020. PMID: 32333835 Free PMC article. Review.
Biological aging involves an interplay of conserved and targetable molecular mechanisms, summarized as the hallmarks of aging. Metformin, a biguanide that combats age-related disorders and improves health span, is the first drug to be tested for its age-targeting effects i …
Biological aging involves an interplay of conserved and targetable molecular mechanisms, summarized as the hallmarks of aging. Metformin …
A Critical Review of the Evidence That Metformin Is a Putative Anti-Aging Drug That Enhances Healthspan and Extends Lifespan.
Mohammed I, Hollenberg MD, Ding H, Triggle CR. Mohammed I, et al. Front Endocrinol (Lausanne). 2021 Aug 5;12:718942. doi: 10.3389/fendo.2021.718942. eCollection 2021. Front Endocrinol (Lausanne). 2021. PMID: 34421827 Free PMC article. Review.
Indeed, clinical trials, including the MILES (Metformin In Longevity Study) and TAME (Targeting Aging with Metformin), have been designed to assess the potential benefits of metformin as an anti-aging drug. Preliminary analysis of results from MILES indicate …
Indeed, clinical trials, including the MILES (Metformin In Longevity Study) and TAME (Targeting Aging with Metformin), have be …
Metformin, Macrophage Dysfunction and Atherosclerosis.
Feng X, Chen W, Ni X, Little PJ, Xu S, Tang L, Weng J. Feng X, et al. Front Immunol. 2021 Jun 7;12:682853. doi: 10.3389/fimmu.2021.682853. eCollection 2021. Front Immunol. 2021. PMID: 34163481 Free PMC article. Review.
Metformin is one of the most widely prescribed hypoglycemic drugs and has the potential to treat many diseases. ...On the basis of summarizing these studies, we further discussed the future research directions of metformin: single-cell RNA sequencing, neutrophil ext …
Metformin is one of the most widely prescribed hypoglycemic drugs and has the potential to treat many diseases. ...On the basis of su …
Metformin and the gastrointestinal tract.
McCreight LJ, Bailey CJ, Pearson ER. McCreight LJ, et al. Diabetologia. 2016 Mar;59(3):426-35. doi: 10.1007/s00125-015-3844-9. Epub 2016 Jan 16. Diabetologia. 2016. PMID: 26780750 Free PMC article. Review.
A novel delayed-release preparation of metformin has recently been shown to improve glycaemic control to a similar extent to immediate-release metformin, but with less systemic exposure. ...This review examines the passage of metformin through the gut, and ho …
A novel delayed-release preparation of metformin has recently been shown to improve glycaemic control to a similar extent to immediat …
Understanding and overcoming metformin gastrointestinal intolerance.
Bonnet F, Scheen A. Bonnet F, et al. Diabetes Obes Metab. 2017 Apr;19(4):473-481. doi: 10.1111/dom.12854. Epub 2017 Feb 22. Diabetes Obes Metab. 2017. PMID: 27987248 Review.
Although starting at a low dose and titrating slowly may help prevent some GI AEs associated with metformin, some patients are unable to tolerate metformin at all and it may also be difficult to convince patients to start metformin again after a bout of GI AE …
Although starting at a low dose and titrating slowly may help prevent some GI AEs associated with metformin, some patients are unable …
Metformin in cancer treatment and prevention.
Morales DR, Morris AD. Morales DR, et al. Annu Rev Med. 2015;66:17-29. doi: 10.1146/annurev-med-062613-093128. Epub 2014 Nov 6. Annu Rev Med. 2015. PMID: 25386929 Review.
Basic science has provided a better understanding of the mechanism of action of metformin and the potential for metformin to modulate molecular pathways involved in cancer cell signaling and metabolism. This article outlines the link between metformin and can …
Basic science has provided a better understanding of the mechanism of action of metformin and the potential for metformin to m …
Metformin: historical overview.
Bailey CJ. Bailey CJ. Diabetologia. 2017 Sep;60(9):1566-1576. doi: 10.1007/s00125-017-4318-z. Epub 2017 Aug 3. Diabetologia. 2017. PMID: 28776081
Metformin (dimethylbiguanide) has become the preferred first-line oral blood glucose-lowering agent to manage type 2 diabetes. ...Long-term cardiovascular benefits of metformin were identified by the UK Prospective Diabetes Study (UKPDS) in 1998, providing a new rat …
Metformin (dimethylbiguanide) has become the preferred first-line oral blood glucose-lowering agent to manage type 2 diabetes. ...Lon …
27,470 results
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