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Page 1
Small Intestinal Bacterial Overgrowth and Irritable Bowel Syndrome - An Update.
Takakura W, Pimentel M. Takakura W, et al. Front Psychiatry. 2020 Jul 10;11:664. doi: 10.3389/fpsyt.2020.00664. eCollection 2020. Front Psychiatry. 2020. PMID: 32754068 Free PMC article. Review.
Numerous pathogenic organisms have been shown to be increased in subjects with SIBO and IBS, including but not limited to Enterococcus, Escherichia coli, and Klebsiella. In addition, Methanobrevibacter smithii, the causal organism in a positive methane breath test, …
Numerous pathogenic organisms have been shown to be increased in subjects with SIBO and IBS, including but not limited to Enterococcus, Esch …
Methanobrevibacter smithii is the predominant methanogen in patients with constipation-predominant IBS and methane on breath.
Kim G, Deepinder F, Morales W, Hwang L, Weitsman S, Chang C, Gunsalus R, Pimentel M. Kim G, et al. Dig Dis Sci. 2012 Dec;57(12):3213-8. doi: 10.1007/s10620-012-2197-1. Epub 2012 May 10. Dig Dis Sci. 2012. PMID: 22573345
PURPOSE: Among irritable bowel syndrome (IBS) patients, breath methane producers overwhelmingly have constipation predominance (C-IBS). Although the most common methanogen in humans is Methanobrevibacter smithii, incidence and type of methanogenic bacteria in …
PURPOSE: Among irritable bowel syndrome (IBS) patients, breath methane producers overwhelmingly have constipation predominance (C-IBS …
Hydrogen Sulfide and Methane on Breath Test Correlate with Human Small Intestinal Hydrogen Sulfide Producers and Methanogens.
Villanueva-Millan MJ, Leite G, Mathur R, Rezaie A, Fajardo CM, de Freitas Germano J, Morales W, Sanchez M, Rivera I, Parodi G, Weitsman S, Rashid M, Hosseini A, Brimberry D, Barlow GM, Pimentel M. Villanueva-Millan MJ, et al. Dig Dis Sci. 2025 Nov;70(11):3846-3856. doi: 10.1007/s10620-025-09156-y. Epub 2025 Jun 26. Dig Dis Sci. 2025. PMID: 40569514 Free PMC article.
Breath methane (CH(4)) levels correlate with stool Methanobrevibacter smithii levels and constipation, while hydrogen sulfide (H(2)S) levels correlate with stool H(2)S producers and diarrhea. ...M. smithii prevalence correlated with known hydrogen-prod …
Breath methane (CH(4)) levels correlate with stool Methanobrevibacter smithii levels and constipation, while hydrogen s …
Impact of prebiotics and postbiotics in the management of constipation: Analysis of their differentiated modulation of intestinal microbiota.
Culqui Lévano DR, Rodríguez Sanz P, Palacios Sanchez R, Saldaña Miranda MY, Santa Cruz López CY, Mateus Rodríguez JA. Culqui Lévano DR, et al. Clin Nutr ESPEN. 2025 Oct;69:625-633. doi: 10.1016/j.clnesp.2025.08.003. Epub 2025 Aug 6. Clin Nutr ESPEN. 2025. PMID: 40780410 Free article. Clinical Trial.
Chronic constipation represents a burden in the modern world and is most prevalent in the elderly. ...Consumption of NextDext increased the presence of some beneficial bacterial groups, such as Bifidobacterium longum and Roseburia hominis, and reduced the presence of micr …
Chronic constipation represents a burden in the modern world and is most prevalent in the elderly. ...Consumption of NextDext increa …
Gut Microbiota-Based Therapies for Irritable Bowel Syndrome.
Stern EK, Brenner DM. Stern EK, et al. Clin Transl Gastroenterol. 2018 Feb 15;9(2):e134. doi: 10.1038/ctg.2018.2. Clin Transl Gastroenterol. 2018. PMID: 29446765 Free PMC article.
SYN-010 is a modified-release statin formulation that reduces methane production by Methanobrevibacter smithii and is currently in development for the treatment of patients with constipation-predominant IBS. ...
SYN-010 is a modified-release statin formulation that reduces methane production by Methanobrevibacter smithii and is currentl …
Hydrogen Sulfide Producers Drive a Diarrhea-Like Phenotype and a Methane Producer Drives a Constipation-Like Phenotype in Animal Models.
Villanueva-Millan MJ, Leite G, Morales W, Sanchez M, Parodi G, Weitsman S, Celly S, Cohrs D, Do H, Barlow GM, Mathur R, Rezaie A, Pimentel M. Villanueva-Millan MJ, et al. Dig Dis Sci. 2024 Feb;69(2):426-436. doi: 10.1007/s10620-023-08197-5. Epub 2023 Dec 7. Dig Dis Sci. 2024. PMID: 38060167 Free PMC article.
BACKGROUND: We recently demonstrated that diarrhea-predominant irritable bowel syndrome (IBS-D) subjects have higher relative abundance (RA) of hydrogen sulfide (H(2)S)-producing Fusobacterium and Desulfovibrio species, and constipation-predominant IBS (IBS-C) subjects hav …
BACKGROUND: We recently demonstrated that diarrhea-predominant irritable bowel syndrome (IBS-D) subjects have higher relative abundance (RA) …
Methanogens and Hydrogen Sulfide Producing Bacteria Guide Distinct Gut Microbe Profiles and Irritable Bowel Syndrome Subtypes.
Villanueva-Millan MJ, Leite G, Wang J, Morales W, Parodi G, Pimentel ML, Barlow GM, Mathur R, Rezaie A, Sanchez M, Ayyad S, Cohrs D, Chang C, Rashid M, Hosseini A, Fiorentino A, Weitsman S, Chuang B, Chang B, Pichetshote N, Pimentel M. Villanueva-Millan MJ, et al. Am J Gastroenterol. 2022 Dec 1;117(12):2055-2066. doi: 10.14309/ajg.0000000000001997. Epub 2022 Sep 6. Am J Gastroenterol. 2022. PMID: 36114762 Free PMC article.
INTRODUCTION: Irritable bowel syndrome (IBS) includes diarrhea-predominant (IBS-D) and constipation-predominant (IBS-C) subtypes. We combined breath testing and stool microbiome sequencing to identify potential microbial drivers of IBS subtypes. ...RESULTS: IBS-C subjects …
INTRODUCTION: Irritable bowel syndrome (IBS) includes diarrhea-predominant (IBS-D) and constipation-predominant (IBS-C) subtypes. We …
Review article: inhibition of methanogenic archaea by statins as a targeted management strategy for constipation and related disorders.
Gottlieb K, Wacher V, Sliman J, Pimentel M. Gottlieb K, et al. Aliment Pharmacol Ther. 2016 Jan;43(2):197-212. doi: 10.1111/apt.13469. Epub 2015 Nov 11. Aliment Pharmacol Ther. 2016. PMID: 26559904 Free PMC article. Review.
Archaea are the only confirmed biological sources of methane in nature and Methanobrevibacter smithii is the predominant methanogen in the human intestine. AIM: To review the biosynthesis and composition of archaeal cell membranes, archaeal methanogenesis and the me …
Archaea are the only confirmed biological sources of methane in nature and Methanobrevibacter smithii is the predominant metha …
A Single Fasting Exhaled Methane Level Correlates With Fecal Methanogen Load, Clinical Symptoms and Accurately Detects Intestinal Methanogen Overgrowth.
Takakura W, Pimentel M, Rao S, Villanueva-Millan MJ, Chang C, Morales W, Sanchez M, Torosyan J, Rashid M, Hosseini A, Wang J, Leite G, Kowalewski E, Mathur R, Rezaie A. Takakura W, et al. Am J Gastroenterol. 2022 Mar 1;117(3):470-477. doi: 10.14309/ajg.0000000000001607. Am J Gastroenterol. 2022. PMID: 35041624 Clinical Trial.
Third, in a double-blind randomized control trial, the temporal stability of SMM levels in subjects taking placebo was analyzed. Fourth, stool Methanobrevibacter smithii loads were quantified using quantitative polymerase chain reaction and compared with SMM levels. …
Third, in a double-blind randomized control trial, the temporal stability of SMM levels in subjects taking placebo was analyzed. Fourth, sto …
Development of a Modified-Release Formulation of Lovastatin Targeted to Intestinal Methanogens Implicated in Irritable Bowel Syndrome With Constipation.
Hubert S, Chadwick A, Wacher V, Coughlin O, Kokai-Kun J, Bristol A. Hubert S, et al. J Pharm Sci. 2018 Feb;107(2):662-671. doi: 10.1016/j.xphs.2017.09.028. Epub 2017 Oct 6. J Pharm Sci. 2018. PMID: 28989013 Free article.
There is growing evidence that methane production, predominantly by Methanobrevibacter smithii, in the intestines is a cause of constipation, pain, and bloating in irritable bowel syndrome with constipation (IBS-C). M smithii resides primarily i …
There is growing evidence that methane production, predominantly by Methanobrevibacter smithii, in the intestines is a cause o …
14 results