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The ancient cell death suppressor BAX inhibitor-1.
Henke N, Lisak DA, Schneider L, Habicht J, Pergande M, Methner A. Henke N, et al. Cell Calcium. 2011 Sep;50(3):251-60. doi: 10.1016/j.ceca.2011.05.005. Epub 2011 Jun 12. Cell Calcium. 2011. PMID: 21663964 Review.
It is evolutionarily conserved and orthologues from plants can substitute for mammalian BI-1 in regard to its anti-apoptotic function suggesting a high degree of functional conservation. ...We also present a thorough phylogenetic analysis of BI-1 proteins from major …
It is evolutionarily conserved and orthologues from plants can substitute for mammalian BI-1 in regard to its anti-apoptotic function sugges …
The constitutively active orphan G-protein-coupled receptor GPR39 protects from cell death by increasing secretion of pigment epithelium-derived growth factor.
Dittmer S, Sahin M, Pantlen A, Saxena A, Toutzaris D, Pina AL, Geerts A, Golz S, Methner A. Dittmer S, et al. J Biol Chem. 2008 Mar 14;283(11):7074-81. doi: 10.1074/jbc.M704323200. Epub 2008 Jan 7. J Biol Chem. 2008. PMID: 18180304
GPR39 is a constitutively active orphan G-protein-coupled receptor capable of increasing serum response element-mediated transcription. ...We conclude that GPR39 is a novel inhibitor of cell death, which might represent a therapeutic target with implications …
GPR39 is a constitutively active orphan G-protein-coupled receptor capable of increasing serum response element-mediated transcriptio …
A novel giant peroxisomal superoxide dismutase motif-containing protein.
Toutzaris D, Lewerenz J, Albrecht P, Jensen LT, Letz J, Geerts A, Golz S, Methner A. Toutzaris D, et al. Free Radic Biol Med. 2010 Mar 15;48(6):811-20. doi: 10.1016/j.freeradbiomed.2009.12.023. Epub 2010 Jan 4. Free Radic Biol Med. 2010. PMID: 20045724
One of these coded for a novel protein of 3440 amino acids comprising a superoxide dismutase (SOD) motif, which we named TIGR for "transcript increased in glutamate resistance." ...Despite the presence of a SOD motif, which is necessary for protection in mamm …
One of these coded for a novel protein of 3440 amino acids comprising a superoxide dismutase (SOD) motif, which we named TIGR …
TOX3 is a neuronal survival factor that induces transcription depending on the presence of CITED1 or phosphorylated CREB in the transcriptionally active complex.
Dittmer S, Kovacs Z, Yuan SH, Siszler G, Kögl M, Summer H, Geerts A, Golz S, Shioda T, Methner A. Dittmer S, et al. J Cell Sci. 2011 Jan 15;124(Pt 2):252-60. doi: 10.1242/jcs.068759. Epub 2010 Dec 15. J Cell Sci. 2011. PMID: 21172805
TOX3 is a nuclear protein containing a high mobility group (HMG)-box domain, which regulates Ca(2+)-dependent transcription in neurons through interaction with the cAMP-response-element-binding protein (CREB). TOX3 appears to be associated with breast cancer suscept …
TOX3 is a nuclear protein containing a high mobility group (HMG)-box domain, which regulates Ca(2+)-dependent transcription in …
Charcot-Marie-Tooth disease CMT4A: GDAP1 increases cellular glutathione and the mitochondrial membrane potential.
Noack R, Frede S, Albrecht P, Henke N, Pfeiffer A, Knoll K, Dehmel T, Meyer Zu Hörste G, Stettner M, Kieseier BC, Summer H, Golz S, Kochanski A, Wiedau-Pazos M, Arnold S, Lewerenz J, Methner A. Noack R, et al. Hum Mol Genet. 2012 Jan 1;21(1):150-62. doi: 10.1093/hmg/ddr450. Epub 2011 Sep 28. Hum Mol Genet. 2012. PMID: 21965300
Over-expression of wild-type GDAP1, but not of GDAP1 with recessively inherited mutations that cause disease and reduce fission activity, increased the total cellular GHS content and the mitochondrial membrane potential up to a level where it apparently limits mitochondria …
Over-expression of wild-type GDAP1, but not of GDAP1 with recessively inherited mutations that cause disease and reduce fission activity, in …
The C terminus of Bax inhibitor-1 forms a Ca2+-permeable channel pore.
Bultynck G, Kiviluoto S, Henke N, Ivanova H, Schneider L, Rybalchenko V, Luyten T, Nuyts K, De Borggraeve W, Bezprozvanny I, Parys JB, De Smedt H, Missiaen L, Methner A. Bultynck G, et al. J Biol Chem. 2012 Jan 20;287(4):2544-57. doi: 10.1074/jbc.M111.275354. Epub 2011 Nov 28. J Biol Chem. 2012. PMID: 22128171 Free PMC article.
Bax inhibitor-1 (BI-1) is a multitransmembrane domain-spanning endoplasmic reticulum (ER)-located protein that is evolutionarily conserved and protects against apoptosis and ER stress. Furthermore, BI-1 is proposed to modulate ER Ca(2+) homeostasis by acting as a Ca …
Bax inhibitor-1 (BI-1) is a multitransmembrane domain-spanning endoplasmic reticulum (ER)-located protein that is evolutionarily cons …
Bax inhibitor-1 is a novel IP₃ receptor-interacting and -sensitizing protein.
Kiviluoto S, Schneider L, Luyten T, Vervliet T, Missiaen L, De Smedt H, Parys JB, Methner A, Bultynck G. Kiviluoto S, et al. Cell Death Dis. 2012 Aug 9;3(8):e367. doi: 10.1038/cddis.2012.103. Cell Death Dis. 2012. PMID: 22875004 Free PMC article. No abstract available.
Stromal interaction molecule 1 (STIM1) is involved in the regulation of mitochondrial shape and bioenergetics and plays a role in oxidative stress.
Henke N, Albrecht P, Pfeiffer A, Toutzaris D, Zanger K, Methner A. Henke N, et al. J Biol Chem. 2012 Dec 7;287(50):42042-52. doi: 10.1074/jbc.M112.417212. Epub 2012 Oct 17. J Biol Chem. 2012. PMID: 23076152 Free PMC article.
Calcium ions are involved in a plethora of cellular functions including cell death and mitochondrial energy metabolism. Store-operated Ca(2+) entry over the plasma membrane is activated by depletion of intracellular Ca(2+) stores and is mediated by the sensor STIM1 and the …
Calcium ions are involved in a plethora of cellular functions including cell death and mitochondrial energy metabolism. Store-operate …
The plasma membrane channel ORAI1 mediates detrimental calcium influx caused by endogenous oxidative stress.
Henke N, Albrecht P, Bouchachia I, Ryazantseva M, Knoll K, Lewerenz J, Kaznacheyeva E, Maher P, Methner A. Henke N, et al. Cell Death Dis. 2013 Jan 24;4(1):e470. doi: 10.1038/cddis.2012.216. Cell Death Dis. 2013. PMID: 23348584 Free PMC article.
Oxytosis is characterized by an increase of reactive oxygen species and a strong calcium influx preceding cell death. We found a significant reduction in store-operated calcium entry (SOCE) in glutamate-resistant HT22 cells caused by downregulation of the Ca(2+) cha …
Oxytosis is characterized by an increase of reactive oxygen species and a strong calcium influx preceding cell death. We found a
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