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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1953 1
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1963 7
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1974 2
1975 3
1976 7
1977 6
1978 1
1979 7
1980 3
1981 9
1982 10
1983 15
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1985 8
1986 7
1987 3
1988 9
1989 9
1990 11
1991 8
1992 10
1993 4
1994 9
1995 11
1996 9
1997 7
1998 9
1999 8
2000 12
2001 11
2002 16
2003 19
2004 14
2005 23
2006 33
2007 29
2008 23
2009 21
2010 29
2011 32
2012 40
2013 44
2014 50
2015 45
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1,386 results

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Page 1
Effect of methyl p-hydroxybenzoate on the culture of mammalian cell.
Tani H, Takeshita JI, Aoki H, Nakamura K, Abe R, Toyoda A, Endo Y, Miyamoto S, Gamo M, Torimura M, Sato H. Tani H, et al. Drug Discov Ther. 2017;11(5):276-280. doi: 10.5582/ddt.2017.01054. Drug Discov Ther. 2017. PMID: 29162775 Free article.
Several chemicals, such as methyl p-hydroxybenzoate (MHB), have been widely used as preservatives in the water baths of CO(2) incubators used for mammalian cell culture, and they are not considered to produce any biological effects. ...
Several chemicals, such as methyl p-hydroxybenzoate (MHB), have been widely used as preservatives in the water baths of …
Methyl p-hydroxybenzoate causes pain sensation through activation of TRPA1 channels.
Fujita F, Moriyama T, Higashi T, Shima A, Tominaga M. Fujita F, et al. Br J Pharmacol. 2007 May;151(1):153-60. doi: 10.1038/sj.bjp.0707219. Epub 2007 Mar 12. Br J Pharmacol. 2007. PMID: 17351650 Free PMC article.
EXPERIMENTAL APPROACH: Effects of parabens, especially of methyl p-hydroxybenzoate (methyl paraben) on TRP channel activities were examined using Ca(2+)-imaging and patch-clamp methods. ...
EXPERIMENTAL APPROACH: Effects of parabens, especially of methyl p-hydroxybenzoate (methyl paraben) on TRP chann …
A validated stability‐indicating reversed‐phase‐UPLC method for simultaneous estimation of promethazine hydrochloride, methylparaben, propylparaben and sodium benzoate assay of cough suppressant and antihistamine liquid oral dosage forms.
Pippalla S, Nekkalapudi AR, Komreddy VR. Pippalla S, et al. Biomed Chromatogr. 2024 Sep;38(9):e5944. doi: 10.1002/bmc.5944. Epub 2024 Jul 14. Biomed Chromatogr. 2024. PMID: 39004877 French.
A quick, simple, sensitive, efficient and stability-indicating reverse-phase ultraperformance liquid chromatographic method for the estimation of propylparaben, methylparaben and sodium benzoate in a pharmaceutical liquid oral formulation was developed. ...Percentage recov …
A quick, simple, sensitive, efficient and stability-indicating reverse-phase ultraperformance liquid chromatographic method for the estimati …
Mosquito larvicidal activity of methyl-p-hydroxybenzoate isolated from the leaves of Vitex trifolia Linn.
Kannathasan K, Senthilkumar A, Venkatesalu V. Kannathasan K, et al. Acta Trop. 2011 Oct-Nov;120(1-2):115-8. doi: 10.1016/j.actatropica.2011.07.001. Epub 2011 Jul 7. Acta Trop. 2011. PMID: 21763671
In the present study, a crystalline compound methyl-p-hydroxybenzoate was isolated from the methanol extract of Vitex trifolia leaves and it was identified by (1)H and (13)C NMR and single crystal X-ray diffractometer. ...The compound exhibited 100% larval mo …
In the present study, a crystalline compound methyl-p-hydroxybenzoate was isolated from the methanol extract of Vitex t …
Expanded solubility parameter approach. II: p-Hydroxybenzoic acid and methyl p-hydroxybenzoate in individual solvents.
Martin A, Wu PL, Beerbower A. Martin A, et al. J Pharm Sci. 1984 Feb;73(2):188-94. doi: 10.1002/jps.2600730211. J Pharm Sci. 1984. PMID: 6707880
Twenty-two of thirty-six or 61% of the calculated solubility values for methyl p-hydroxybenzoate met the solubility criterion. Experimental excess free energies of solution for p-hydroxybenzoic acid and methyl p-hydroxybenzoate were plott …
Twenty-two of thirty-six or 61% of the calculated solubility values for methyl p-hydroxybenzoate met the solubility cri …
Effects of methyl p-hydroxybenzoate (methyl paraben) on Ca2+ concentration and histamine release in rat peritoneal mast cells.
Fukugasako S, Ito S, Ikemoto Y. Fukugasako S, et al. Br J Pharmacol. 2003 May;139(2):381-7. doi: 10.1038/sj.bjp.0705248. Br J Pharmacol. 2003. PMID: 12770943 Free PMC article.
1 Mechanisms of methyl p-hydroxybenzoate (methyl paraben) action in allergic reactions were investigated by measuring the intracellular Ca(2+) concentration ([Ca(2+)](i)) and histamine release in rat peritoneal mast cells (RPMCs). 2 In the presence or …
1 Mechanisms of methyl p-hydroxybenzoate (methyl paraben) action in allergic reactions were investigated by meas …
Methyl p-hydroxybenzoate (E-218) a preservative for drugs and food is an activator of the ryanodine receptor Ca(2+) release channel.
Cavagna D, Zorzato F, Babini E, Prestipino G, Treves S. Cavagna D, et al. Br J Pharmacol. 2000 Sep;131(2):335-41. doi: 10.1038/sj.bjp.0703571. Br J Pharmacol. 2000. PMID: 10991928 Free PMC article.
We tested whether the active Ca(2+)-releasing substance was haloperidol or another compound present in the preparation. 3. Our results show that methyl p-hydroxybenzoate, one of the preservatives and a commonly used anti-microbial agent (E-218) is an activato …
We tested whether the active Ca(2+)-releasing substance was haloperidol or another compound present in the preparation. 3. Our results show …
Determination and confirmation of methyl p-hydroxybenzoate in royal jelly and other foods produced by the honey bee.
Ishiwata H, Takeda Y, Yamada T, Watanabe Y, Hosagai T, Ito S, Sakurai H, Aoki G, Ushiama N. Ishiwata H, et al. Food Addit Contam. 1995 Mar-Apr;12(2):281-5. doi: 10.1080/02652039509374302. Food Addit Contam. 1995. PMID: 7781824
Methyl p-hydroxybenzoate (methyl paraben) in foods produced by the Honey Bee was determined by HPLC and confirmed by GC-MS. ...These results indicate that the methyl p-hydroxybenzoate in royal jelly is not added but is a natural co …
Methyl p-hydroxybenzoate (methyl paraben) in foods produced by the Honey Bee was determined by HPLC and confirme …
Unraveling the Mechanisms of Osteoporosis Triggered by Methylparaben and Monomethyl Phthalate through Integrated Mendelian Randomization, In Silico Simulations, and Experimental Validation.
Liu H, Xu X, Du L, Zhang W, Guo Y, Zhang F, Sun H, Si H, Liu P. Liu H, et al. Environ Sci Technol. 2026 Jan 13;60(1):228-242. doi: 10.1021/acs.est.5c12267. Epub 2025 Dec 17. Environ Sci Technol. 2026. PMID: 41408726
MR analyses leveraging European GWAS data identified methylparaben (MP; OR = 0.973, p < 0.001) and monomethyl phthalate (MMP; OR = 0.984, p = 0.006) as causal agents reducing bone mineral density (BMD), validated across two independent cohorts. ...

MR analyses leveraging European GWAS data identified methylparaben (MP; OR = 0.973, p < 0.001) and monomethyl phthalate (MMP; OR =

…
1,386 results