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1870 1
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1891 1
1896 1
1897 3
1902 2
1903 1
1907 2
1912 2
1914 1
1916 2
1917 1
1918 1
1920 1
1923 1
1924 3
1925 4
1926 3
1927 2
1928 5
1929 2
1930 2
1931 3
1932 7
1933 3
1934 1
1935 4
1936 7
1937 5
1938 3
1939 3
1940 6
1941 5
1942 6
1943 10
1944 8
1945 55
1946 136
1947 214
1948 248
1949 185
1950 179
1951 209
1952 184
1953 192
1954 165
1955 196
1956 224
1957 225
1958 269
1959 245
1960 286
1961 331
1962 399
1963 504
1964 524
1965 538
1966 552
1967 714
1968 812
1969 895
1970 916
1971 1214
1972 1373
1973 1415
1974 1451
1975 2383
1976 2515
1977 2345
1978 2248
1979 2333
1980 2456
1981 2757
1982 2916
1983 3406
1984 3687
1985 4028
1986 4365
1987 4489
1988 4894
1989 5513
1990 6009
1991 6192
1992 6737
1993 7011
1994 7353
1995 7550
1996 7969
1997 7981
1998 8148
1999 8417
2000 9461
2001 9839
2002 10250
2003 11110
2004 11894
2005 13063
2006 14194
2007 14711
2008 15801
2009 16138
2010 17857
2011 19030
2012 20098
2013 20770
2014 21013
2015 21181
2016 20433
2017 20468
2018 20865
2019 21212
2020 22686
2021 23108
2022 22839
2023 21748
2024 6368

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518,509 results

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The following term was not found in PubMed: N-benzylidene-2-aminobenzoate
Page 1
Methylation multiplicity and its clinical values in cancer.
Dai X, Ren T, Zhang Y, Nan N. Dai X, et al. Expert Rev Mol Med. 2021 Mar 31;23:e2. doi: 10.1017/erm.2021.4. Expert Rev Mol Med. 2021. PMID: 33787478 Free PMC article. Review.
To aid in the diagnostic and therapeutic design for cancer treatment utilising methylation, this review provides a boutique yet comprehensive overview on methylation at different levels including the mechanisms, cross-talking and clinical implications with a particu …
To aid in the diagnostic and therapeutic design for cancer treatment utilising methylation, this review provides a boutique yet compr …
The N(6)-methyladenosine (m(6)A)-forming enzyme METTL3 facilitates M1 macrophage polarization through the methylation of STAT1 mRNA.
Liu Y, Liu Z, Tang H, Shen Y, Gong Z, Xie N, Zhang X, Wang W, Kong W, Zhou Y, Fu Y. Liu Y, et al. Am J Physiol Cell Physiol. 2019 Oct 1;317(4):C762-C775. doi: 10.1152/ajpcell.00212.2019. Epub 2019 Jul 31. Am J Physiol Cell Physiol. 2019. PMID: 31365297 Free article.
Conversely, its overexpression via plasmid transfection greatly facilitated M1, but attenuated M2, macrophage polarization. Further methylated RNA immunoprecipitation and in vitro m(6)A methylation assays suggested that METTL3 directly methylates mRNA encodin …
Conversely, its overexpression via plasmid transfection greatly facilitated M1, but attenuated M2, macrophage polarization. Further methy
N,N,N',N'-Tetramethylethylenediamine-Enabled Photoredox-Catalyzed C-H Methylation of N-Heteroarenes.
Liu F, Ye ZP, Hu YZ, Gao J, Zheng L, Chen K, Xiang HY, Chen XQ, Yang H. Liu F, et al. J Org Chem. 2021 Sep 3;86(17):11905-11914. doi: 10.1021/acs.joc.1c01325. Epub 2021 Aug 3. J Org Chem. 2021. PMID: 34344150
Aiming at the valuable methylation process, readily available and inexpensive N,N,N',N'-tetramethylethylenediamine (TMEDA) was first identified as a new methyl source in photoredox-catalyzed transformation in this work. By virtue of this simple methylating re …
Aiming at the valuable methylation process, readily available and inexpensive N,N,N',N'-tetramethylethylenediamine (TMEDA) was first …
Epigenetics: Methylating patterns.
Dart A. Dart A. Nat Rev Cancer. 2018 Apr;18(4):206. doi: 10.1038/nrc.2018.21. Epub 2018 Mar 9. Nat Rev Cancer. 2018. PMID: 29520088 No abstract available.
Methods for Direct Reductive N-Methylation of Nitro Compounds.
Jiang Z, Mahmood EA, Harofteh NZ, Ebadi AG, Toughani M, Vessally E. Jiang Z, et al. Top Curr Chem (Cham). 2022 May 24;380(4):27. doi: 10.1007/s41061-022-00382-w. Top Curr Chem (Cham). 2022. PMID: 35606628 Review.
Direct reductive N-methylation of inexpensive and readily available nitro compounds as raw material feedstocks is more attractive and straightforward compared with conventional N-methylation of amines to prepare biologically and pharmaceutically important N-methy
Direct reductive N-methylation of inexpensive and readily available nitro compounds as raw material feedstocks is more attractive and …
Biosynthesis: Methylating mushrooms.
Bowers AA. Bowers AA. Nat Chem Biol. 2017 Jul 18;13(8):821-822. doi: 10.1038/nchembio.2437. Nat Chem Biol. 2017. PMID: 28853736 No abstract available.
Microbial mercury transformations: Molecules, functions and organisms.
Yu RQ, Barkay T. Yu RQ, et al. Adv Appl Microbiol. 2022;118:31-90. doi: 10.1016/bs.aambs.2022.03.001. Epub 2022 Apr 13. Adv Appl Microbiol. 2022. PMID: 35461663 Review.
The discovery of the Hg methylation genes, hgcAB, in the last decade together with advances in high throughput and genome sequencing methods, have resulted in an expanded appreciation of the diversity of Hg methylating microbes. This review aims to describe experime …
The discovery of the Hg methylation genes, hgcAB, in the last decade together with advances in high throughput and genome sequencing …
Enzymatic methylation of the amide bond.
Song H, Naismith JH. Song H, et al. Curr Opin Struct Biol. 2020 Dec;65:79-88. doi: 10.1016/j.sbi.2020.06.004. Epub 2020 Jul 10. Curr Opin Struct Biol. 2020. PMID: 32653730 Review.
The amide bond with its planarity and lack of chemical reactivity is at the heart of protein structure. Chemical methylation of amides is known but was considered too harsh to be accessible to biology. ...This was the first definitive evidence that an enzyme could methy
The amide bond with its planarity and lack of chemical reactivity is at the heart of protein structure. Chemical methylation of amide …
Mutations in RNA methylating enzymes in disease.
Stojković V, Fujimori DG. Stojković V, et al. Curr Opin Chem Biol. 2017 Dec;41:20-27. doi: 10.1016/j.cbpa.2017.10.002. Epub 2017 Oct 20. Curr Opin Chem Biol. 2017. PMID: 29059606 Free PMC article. Review.
However, the functional roles for the majority of these methylations remain largely unclear. In eukaryotes, many RNA methylations have been suggested to participate in fundamental cellular processes. Mutations in eukaryotic RNA methylating enzymes, and a cons …
However, the functional roles for the majority of these methylations remain largely unclear. In eukaryotes, many RNA methylations
Backbone N-methylation of peptides: Advances in synthesis and applications in pharmaceutical drug development.
Li X, Wang N, Liu Y, Li W, Bai X, Liu P, He CY. Li X, et al. Bioorg Chem. 2023 Dec;141:106892. doi: 10.1016/j.bioorg.2023.106892. Epub 2023 Sep 27. Bioorg Chem. 2023. PMID: 37776681 Review.
One prominent strategy for enhancing the druggability of peptides is N-methylation, which involves the addition of a methyl group to the nitrogen atom of the peptide backbone. ...Moreover, we explore the versatile effects of N-methylation on various aspects o …
One prominent strategy for enhancing the druggability of peptides is N-methylation, which involves the addition of a methyl gr …
518,509 results
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