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Hydroxylation of hypoxia-inducible transcription factors and chemical compounds targeting the HIF-alpha hydroxylases.
Bruegge K, Jelkmann W, Metzen E. Bruegge K, et al. Among authors: metzen e. Curr Med Chem. 2007;14(17):1853-62. doi: 10.2174/092986707781058850. Curr Med Chem. 2007. PMID: 17627521 Review.
The hypoxia-inducible transcription factors (HIFs) are central components in the cellular responses to a lack of O(2), i.e. hypoxia. ...
The hypoxia-inducible transcription factors (HIFs) are central components in the cellular responses to a lack of O(2), i.e. hypoxia. …
Evidence against a major role for Ca2+ in hypoxia-induced gene expression in human hepatoma cells (Hep3B).
Metzen E, Fandrey J, Jelkmann W. Metzen E, et al. J Physiol. 1999 Jun 15;517 ( Pt 3)(Pt 3):651-7. doi: 10.1111/j.1469-7793.1999.0651s.x. J Physiol. 1999. PMID: 10358107 Free PMC article.
Interleukin-1beta and tumor necrosis factor-alpha stimulate DNA binding of hypoxia-inducible factor-1.
Hellwig-Bürgel T, Rutkowski K, Metzen E, Fandrey J, Jelkmann W. Hellwig-Bürgel T, et al. Among authors: metzen e. Blood. 1999 Sep 1;94(5):1561-7. Blood. 1999. PMID: 10477681
Hypoxia and interleukin-1beta stimulate vascular endothelial growth factor production in human proximal tubular cells.
El Awad B, Kreft B, Wolber EM, Hellwig-Bürgel T, Metzen E, Fandrey J, Jelkmann W. El Awad B, et al. Among authors: metzen e. Kidney Int. 2000 Jul;58(1):43-50. doi: 10.1046/j.1523-1755.2000.00139.x. Kidney Int. 2000. PMID: 10886548
Vascular endothelial growth factor gene expression in the human breast cancer cell line MX-1 is controlled by O2 availability in vitro and in vivo.
Marxsen JH, Schmitt O, Metzen E, Jelkmann W, Hellwig-Bürgel T. Marxsen JH, et al. Among authors: metzen e. Ann Anat. 2001 May;183(3):243-9. doi: 10.1016/S0940-9602(01)80225-9. Ann Anat. 2001. PMID: 11396794
C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation.
Epstein AC, Gleadle JM, McNeill LA, Hewitson KS, O'Rourke J, Mole DR, Mukherji M, Metzen E, Wilson MI, Dhanda A, Tian YM, Masson N, Hamilton DL, Jaakkola P, Barstead R, Hodgkin J, Maxwell PH, Pugh CW, Schofield CJ, Ratcliffe PJ. Epstein AC, et al. Among authors: metzen e. Cell. 2001 Oct 5;107(1):43-54. doi: 10.1016/s0092-8674(01)00507-4. Cell. 2001. PMID: 11595184
Intracellular localisation of human HIF-1 alpha hydroxylases: implications for oxygen sensing.
Metzen E, Berchner-Pfannschmidt U, Stengel P, Marxsen JH, Stolze I, Klinger M, Huang WQ, Wotzlaw C, Hellwig-Bürgel T, Jelkmann W, Acker H, Fandrey J. Metzen E, et al. J Cell Sci. 2003 Apr 1;116(Pt 7):1319-26. doi: 10.1242/jcs.00318. J Cell Sci. 2003. PMID: 12615973
Nitric oxide impairs normoxic degradation of HIF-1alpha by inhibition of prolyl hydroxylases.
Metzen E, Zhou J, Jelkmann W, Fandrey J, Brüne B. Metzen E, et al. Mol Biol Cell. 2003 Aug;14(8):3470-81. doi: 10.1091/mbc.e02-12-0791. Epub 2003 May 3. Mol Biol Cell. 2003. PMID: 12925778 Free PMC article.
It is appreciated that HIF-1alpha accumulation is achieved under normoxic conditions by e.g., nitric oxide. We determined molecular mechanisms of HIF-1alpha accumulation under the impact of S-nitrosoglutathione (GSNO). ...
It is appreciated that HIF-1alpha accumulation is achieved under normoxic conditions by e.g., nitric oxide. We determined molecular m …
Hypoxia-inducible factor-1 (HIF-1) promotes its degradation by induction of HIF-alpha-prolyl-4-hydroxylases.
Marxsen JH, Stengel P, Doege K, Heikkinen P, Jokilehto T, Wagner T, Jelkmann W, Jaakkola P, Metzen E. Marxsen JH, et al. Among authors: metzen e. Biochem J. 2004 Aug 1;381(Pt 3):761-7. doi: 10.1042/BJ20040620. Biochem J. 2004. PMID: 15104534 Free PMC article.
HIF hydroxylation and cellular oxygen sensing.
Metzen E, Ratcliffe PJ. Metzen E, et al. Biol Chem. 2004 Mar-Apr;385(3-4):223-30. doi: 10.1515/BC.2004.016. Biol Chem. 2004. PMID: 15134335 Review.
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