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A new perspective for schizophrenia: TAAR1 agonists reveal antipsychotic- and antidepressant-like activity, improve cognition and control body weight.
Revel FG, Moreau JL, Pouzet B, Mory R, Bradaia A, Buchy D, Metzler V, Chaboz S, Groebke Zbinden K, Galley G, Norcross RD, Tuerck D, Bruns A, Morairty SR, Kilduff TS, Wallace TL, Risterucci C, Wettstein JG, Hoener MC. Revel FG, et al. Among authors: metzler v. Mol Psychiatry. 2013 May;18(5):543-56. doi: 10.1038/mp.2012.57. Epub 2012 May 29. Mol Psychiatry. 2013. PMID: 22641180
TAAR1 activation modulates monoaminergic neurotransmission, preventing hyperdopaminergic and hypoglutamatergic activity.
Revel FG, Moreau JL, Gainetdinov RR, Bradaia A, Sotnikova TD, Mory R, Durkin S, Zbinden KG, Norcross R, Meyer CA, Metzler V, Chaboz S, Ozmen L, Trube G, Pouzet B, Bettler B, Caron MG, Wettstein JG, Hoener MC. Revel FG, et al. Among authors: metzler v. Proc Natl Acad Sci U S A. 2011 May 17;108(20):8485-90. doi: 10.1073/pnas.1103029108. Epub 2011 Apr 27. Proc Natl Acad Sci U S A. 2011. PMID: 21525407 Free PMC article.
The KDM5B and KDM1A lysine demethylases cooperate in regulating androgen receptor expression and signalling in prostate cancer.
Metzler VM, de Brot S, Haigh DB, Woodcock CL, Lothion-Roy J, Harris AE, Nilsson EM, Ntekim A, Persson JL, Robinson BD, Khani F, Laursen KB, Gudas LJ, Toss MS, Madhusudan S, Rakha E, Heery DM, Rutland CS, Mongan NP, Jeyapalan JN. Metzler VM, et al. Front Cell Dev Biol. 2023 Apr 19;11:1116424. doi: 10.3389/fcell.2023.1116424. eCollection 2023. Front Cell Dev Biol. 2023. PMID: 37152294 Free PMC article.
Clinical and molecular significance of the RNA m6A methyltransferase complex in prostate cancer.
Lothion-Roy J, Haigh DB, Harris AE, Metzler VM, Alsaleem M, Toss MS, Kariri Y, Ntekim A, Robinson BD, Khani F, Gudas LJ, Allegrucci C, James VH, Madhusudan S, Mather M, Emes RD, Archer N, Fray RG, Rakha E, Jeyapalan JN, Rutland CS, Mongan NP, Woodcock CL. Lothion-Roy J, et al. Among authors: metzler vm. Front Genet. 2023 Jan 12;13:1096071. doi: 10.3389/fgene.2022.1096071. eCollection 2022. Front Genet. 2023. PMID: 36733939 Free PMC article.
The METTL3 RNA Methyltransferase Regulates Transcriptional Networks in Prostate Cancer.
Haigh DB, Woodcock CL, Lothion-Roy J, Harris AE, Metzler VM, Persson JL, Robinson BD, Khani F, Alsaleem M, Ntekim A, Madhusudan S, Davis MB, Laursen KB, Gudas LJ, Rutland CS, Toss MS, Archer N, Bodi Z, Rakha EA, Fray RG, Jeyapalan JN, Mongan NP. Haigh DB, et al. Among authors: metzler vm. Cancers (Basel). 2022 Oct 20;14(20):5148. doi: 10.3390/cancers14205148. Cancers (Basel). 2022. PMID: 36291932 Free PMC article.
Exploring anti-androgen therapies in hormone dependent prostate cancer and new therapeutic routes for castration resistant prostate cancer.
Harris AE, Metzler VM, Lothion-Roy J, Varun D, Woodcock CL, Haigh DB, Endeley C, Haque M, Toss MS, Alsaleem M, Persson JL, Gudas LJ, Rakha E, Robinson BD, Khani F, Martin LM, Moyer JE, Brownlie J, Madhusudan S, Allegrucci C, James VH, Rutland CS, Fray RG, Ntekim A, de Brot S, Mongan NP, Jeyapalan JN. Harris AE, et al. Among authors: metzler vm. Front Endocrinol (Lausanne). 2022 Oct 3;13:1006101. doi: 10.3389/fendo.2022.1006101. eCollection 2022. Front Endocrinol (Lausanne). 2022. PMID: 36263323 Free PMC article. Review.
Comparative pathology of dog and human prostate cancer.
Ryman-Tubb T, Lothion-Roy JH, Metzler VM, Harris AE, Robinson BD, Rizvanov AA, Jeyapalan JN, James VH, England G, Rutland CS, Persson JL, Kenner L, Rubin MA, Mongan NP, de Brot S. Ryman-Tubb T, et al. Among authors: metzler vm. Vet Med Sci. 2022 Jan;8(1):110-120. doi: 10.1002/vms3.642. Epub 2021 Oct 10. Vet Med Sci. 2022. PMID: 34628719 Free PMC article. Review.
30 results