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Biotechnological synthesis of drug metabolites using human cytochrome P450 2D6 heterologously expressed in fission yeast exemplified for the designer drug metabolite 4'-hydroxymethyl-alpha-pyrrolidinobutyrophenone.
Peters FT, Dragan CA, Wilde DR, Meyer MR, Zapp J, Bureik M, Maurer HH. Peters FT, et al. Among authors: meyer mr. Biochem Pharmacol. 2007 Aug 1;74(3):511-20. doi: 10.1016/j.bcp.2007.05.010. Epub 2007 May 18. Biochem Pharmacol. 2007. PMID: 17572388
351 results