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Analysis of telomerase processivity: mechanistic similarity to HIV-1 reverse transcriptase and role in telomere maintenance.
Peng Y, Mian IS, Lue NF. Peng Y, et al. Among authors: mian is. Mol Cell. 2001 Jun;7(6):1201-11. doi: 10.1016/s1097-2765(01)00268-4. Mol Cell. 2001. PMID: 11430823
The key protein subunit of the telomerase complex, known as TERT, possesses a reverse transcriptase (RT)-like domain that is conserved in enzymes encoded by retroviruses and retroelements. Structural and functional analysis of HIV-1 RT suggests that RT processivity is
The key protein subunit of the telomerase complex, known as TERT, possesses a reverse transcriptase (RT)-like domain that is conserve …
A conserved telomerase motif within the catalytic domain of telomerase reverse transcriptase is specifically required for repeat addition processivity.
Lue NF, Lin YC, Mian IS. Lue NF, et al. Among authors: mian is. Mol Cell Biol. 2003 Dec;23(23):8440-9. doi: 10.1128/mcb.23.23.8440-8449.2003. Mol Cell Biol. 2003. PMID: 14612390 Free PMC article.
Telomerase is a ribonucleoprotein reverse transcriptase responsible for the maintenance of one strand of the telomere terminal repeats. ...Our results suggest that the ability to stabilize short RNA-DNA hybrids is crucial for telomerase function in vivo and that thi …
Telomerase is a ribonucleoprotein reverse transcriptase responsible for the maintenance of one strand of the telomere terminal repeat …
Analysis of telomerase in Candida albicans: potential role in telomere end protection.
Singh SM, Steinberg-Neifach O, Mian IS, Lue NF. Singh SM, et al. Among authors: mian is. Eukaryot Cell. 2002 Dec;1(6):967-77. doi: 10.1128/ec.1.6.967-977.2002. Eukaryot Cell. 2002. PMID: 12477797 Free PMC article.
Telomerase is a ribonucleoprotein reverse transcriptase responsible for the maintenance of one strand of telomere terminal repeats. ...We propose that these two telomerase subunits may participate in the protection of chromosomal ends in Candida: Analysis of telomerase-med …
Telomerase is a ribonucleoprotein reverse transcriptase responsible for the maintenance of one strand of telomere terminal repeats. . …
Arabidopsis thaliana exosome subunit AtRrp4p is a hydrolytic 3'-->5' exonuclease containing S1 and KH RNA-binding domains.
Chekanova JA, Dutko JA, Mian IS, Belostotsky DA. Chekanova JA, et al. Among authors: mian is. Nucleic Acids Res. 2002 Feb 1;30(3):695-700. doi: 10.1093/nar/30.3.695. Nucleic Acids Res. 2002. PMID: 11809881 Free PMC article.
The exosome, an evolutionarily conserved complex of multiple 3'-->5' exoribonucleases, is responsible for a variety of RNA processing and degradation events in eukaryotes. ...However, only the full-length protein is capable of degrading RNA and interacting with A …
The exosome, an evolutionarily conserved complex of multiple 3'-->5' exoribonucleases, is responsible for a variety of RNA process …
Conserved N-terminal motifs of telomerase reverse transcriptase required for ribonucleoprotein assembly in vivo.
Bosoy D, Peng Y, Mian IS, Lue NF. Bosoy D, et al. Among authors: mian is. J Biol Chem. 2003 Feb 7;278(6):3882-90. doi: 10.1074/jbc.M210645200. Epub 2002 Nov 27. J Biol Chem. 2003. PMID: 12458198
Telomerase is a ribonucleoprotein (RNP) reverse transcriptase responsible for the maintenance of one strand of the telomere terminal repeats. ...
Telomerase is a ribonucleoprotein (RNP) reverse transcriptase responsible for the maintenance of one strand of the telomere terminal …
Identification of functionally important domains in the N-terminal region of telomerase reverse transcriptase.
Xia J, Peng Y, Mian IS, Lue NF. Xia J, et al. Among authors: mian is. Mol Cell Biol. 2000 Jul;20(14):5196-207. doi: 10.1128/mcb.20.14.5196-5207.2000. Mol Cell Biol. 2000. PMID: 10866675 Free PMC article.
Telomerase is a ribonucleoprotein reverse transcriptase responsible for the maintenance of one strand of telomere terminal repeats. ...Deletion analysis indicates that even the most N-terminal nonconserved region of yeast TERT (N region) is required for telomerase f …
Telomerase is a ribonucleoprotein reverse transcriptase responsible for the maintenance of one strand of telomere terminal repeats. . …
Statistical modelling and phylogenetic analysis of a deaminase domain.
Mian IS, Moser MJ, Holley WR, Chatterjee A. Mian IS, et al. J Comput Biol. 1998 Spring;5(1):57-72. doi: 10.1089/cmb.1998.5.57. J Comput Biol. 1998. PMID: 9541871
In some of the newly identified DM domains, the glutamate is changed to a residue that could not function as a proton shuttle and in one instance (Mus musculus spermatid protein TENR) the cysteines are also changed to lysine and serine. ...
In some of the newly identified DM domains, the glutamate is changed to a residue that could not function as a proton shuttle and in …
AZU-1: a candidate breast tumor suppressor and biomarker for tumor progression.
Chen HM, Schmeichel KL, Mian IS, Lelièvre S, Petersen OW, Bissell MJ. Chen HM, et al. Among authors: mian is. Mol Biol Cell. 2000 Apr;11(4):1357-67. doi: 10.1091/mbc.11.4.1357. Mol Biol Cell. 2000. PMID: 10749935 Free PMC article.
These results indicate that AZU-1 is a candidate breast tumor suppressor that may exert its effects by promoting correct tissue morphogenesis....
These results indicate that AZU-1 is a candidate breast tumor suppressor that may exert its effects by promoting correct tissue morph …
Comparative analysis of editosome proteins in trypanosomatids.
Worthey EA, Schnaufer A, Mian IS, Stuart K, Salavati R. Worthey EA, et al. Among authors: mian is. Nucleic Acids Res. 2003 Nov 15;31(22):6392-408. doi: 10.1093/nar/gkg870. Nucleic Acids Res. 2003. PMID: 14602897 Free PMC article.
Two other related proteins, at least one of which is associated with U-specific 3' exonuclease activity, contain two putative nuclease motifs. ...These data indicate that trypanosomatid RNA editing is orchestrated by a variety of domains for catalysis, molecular int …
Two other related proteins, at least one of which is associated with U-specific 3' exonuclease activity, contain two putative nucleas …
SATB1 cleavage by caspase 6 disrupts PDZ domain-mediated dimerization, causing detachment from chromatin early in T-cell apoptosis.
Galande S, Dickinson LA, Mian IS, Sikorska M, Kohwi-Shigematsu T. Galande S, et al. Among authors: mian is. Mol Cell Biol. 2001 Aug;21(16):5591-604. doi: 10.1128/MCB.21.16.5591-5604.2001. Mol Cell Biol. 2001. PMID: 11463840 Free PMC article.
SATB1 is expressed primarily in thymocytes and orchestrates temporal and spatial expression of a large number of genes in the T-cell lineage. ...Here we show that SATB1 is specifically cleaved by a caspase 6-like protease at amino acid position 254 to produce a 65-k …
SATB1 is expressed primarily in thymocytes and orchestrates temporal and spatial expression of a large number of genes in the T-cell …
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