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Mice devoid of the glial fibrillary acidic protein develop normally and are susceptible to scrapie prions.
Gomi H, Yokoyama T, Fujimoto K, Ikeda T, Katoh A, Itoh T, Itohara S. Gomi H, et al. Neuron. 1995 Jan;14(1):29-41. doi: 10.1016/0896-6273(95)90238-4. Neuron. 1995. PMID: 7826639 Free article.
Glial fibrillary acidic protein (GFAP) is an intermediate filament protein specifically expressed in astrocytes in the CNS. ...When inoculated with infectious scrapie prions, the mutant mice exhibited neuropathological chang …
Glial fibrillary acidic protein (GFAP) is an intermediate filament protein specifically expressed in astr …
Astrocyte-specific expression of hamster prion protein (PrP) renders PrP knockout mice susceptible to hamster scrapie.
Raeber AJ, Race RE, Brandner S, Priola SA, Sailer A, Bessen RA, Mucke L, Manson J, Aguzzi A, Oldstone MB, Weissmann C, Chesebro B. Raeber AJ, et al. EMBO J. 1997 Oct 15;16(20):6057-65. doi: 10.1093/emboj/16.20.6057. EMBO J. 1997. PMID: 9321385 Free PMC article.
After inoculation with hamster scrapie, these mice accumulated infectivity and PrPSc to high levels, developed severe disease after 227 +/- 5 days and died 7 +/- 4 days later. Therefore, astrocytes could play an important role in scrapie pathoge …
After inoculation with hamster scrapie, these mice accumulated infectivity and PrPSc to high levels, developed severe …