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TMEM65 regulates and is required for NCLX-dependent mitochondrial calcium efflux.
Garbincius JF, Salik O, Cohen HM, Choya-Foces C, Mangold AS, Makhoul AD, Schmidt AE, Khalil DY, Doolittle JJ, Wilkinson AS, Murray EK, Lazaropoulos MP, Hildebrand AN, Tomar D, Elrod JW. Garbincius JF, et al. Among authors: lazaropoulos mp. Nat Metab. 2025 Apr;7(4):714-729. doi: 10.1038/s42255-025-01250-9. Epub 2025 Apr 8. Nat Metab. 2025. PMID: 40200126 Free PMC article.
Mitochondria in Pathological Cardiac Remodeling.
Lazaropoulos MP, Elrod JW. Lazaropoulos MP, et al. Curr Opin Physiol. 2022 Feb;25:100489. doi: 10.1016/j.cophys.2022.100489. Epub 2022 Feb 19. Curr Opin Physiol. 2022. PMID: 35274068 Free PMC article.
Integrated Systems Biology Identifies Disruptions in Mitochondrial Function and Metabolism as Key Contributors to HFpEF.
Gibb AA, LaPenna K, Gaspar RB, Latchman NR, Tan Y, Choya-Foces C, Doiron JE, Li Z, Xia H, Lazaropoulos MP, Conwell M, Sharp TE 3rd, Goodchild TT, Lefer DJ, Elrod JW. Gibb AA, et al. Among authors: lazaropoulos mp. JACC Basic Transl Sci. 2025 Sep;10(9):101334. doi: 10.1016/j.jacbts.2025.101334. Epub 2025 Aug 15. JACC Basic Transl Sci. 2025. PMID: 40818383 Free PMC article.
TMEM65 regulates NCLX-dependent mitochondrial calcium efflux.
Garbincius JF, Salik O, Cohen HM, Choya-Foces C, Mangold AS, Makhoul AD, Schmidt AE, Khalil DY, Doolittle JJ, Wilkinson AS, Murray EK, Lazaropoulos MP, Hildebrand AN, Tomar D, Elrod JW. Garbincius JF, et al. Among authors: lazaropoulos mp. bioRxiv [Preprint]. 2023 Oct 9:2023.10.06.561062. doi: 10.1101/2023.10.06.561062. bioRxiv. 2023. Update in: Nat Metab. 2025 Apr;7(4):714-729. doi: 10.1038/s42255-025-01250-9. PMID: 37873405 Free PMC article. Updated. Preprint.
Integrated systems biology identifies disruptions in mitochondrial function and metabolism as key contributors to heart failure with preserved ejection fraction (HFpEF).
Gibb AA, LaPenna K, Gaspar RB, Latchman NR, Tan Y, Choya-Foces C, Doiron JE, Li Z, Xia H, Lazaropoulos MP, Conwell M, Sharp TE 3rd, Goodchild TT, Lefer DJ, Elrod JW. Gibb AA, et al. Among authors: lazaropoulos mp. bioRxiv [Preprint]. 2024 Oct 25:2024.10.25.619450. doi: 10.1101/2024.10.25.619450. bioRxiv. 2024. Update in: JACC Basic Transl Sci. 2025 Sep;10(9):101334. doi: 10.1016/j.jacbts.2025.101334. PMID: 39484400 Free PMC article. Updated. Preprint.
Neuropathology of Friedreich ataxia and its links to metabolic pathways.
Mercado-Ayón E, Lazaropoulos MP, Mercado-Ayón Y, Lynch DR. Mercado-Ayón E, et al. Among authors: lazaropoulos mp. Neurodegener Dis Manag. 2025 Dec 25:1-12. doi: 10.1080/17582024.2025.2607957. Online ahead of print. Neurodegener Dis Manag. 2025. PMID: 41447358 Free article. Review.
Glutamine uptake and catabolism is required for myofibroblast formation and persistence.
Gibb AA, Huynh AT, Gaspar RB, Ploesch TL, Lombardi AA, Lorkiewicz PK, Lazaropoulos MP, Bedi K, Arany Z, Margulies KB, Hill BG, Elrod JW. Gibb AA, et al. Among authors: lazaropoulos mp. J Mol Cell Cardiol. 2022 Nov;172:78-89. doi: 10.1016/j.yjmcc.2022.08.002. Epub 2022 Aug 18. J Mol Cell Cardiol. 2022. PMID: 35988357 Free PMC article.
13 results