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The precursor pro-nerve growth factor is the predominant form of nerve growth factor in brain and is increased in Alzheimer's disease.
Fahnestock M, Michalski B, Xu B, Coughlin MD. Fahnestock M, et al. Among authors: michalski b. Mol Cell Neurosci. 2001 Aug;18(2):210-20. doi: 10.1006/mcne.2001.1016. Mol Cell Neurosci. 2001. PMID: 11520181
Continuous infusion of neurotrophin-3 triggers sprouting, decreases the levels of TrkA and TrkC, and inhibits epileptogenesis and activity-dependent axonal growth in adult rats.
Xu B, Michalski B, Racine RJ, Fahnestock M. Xu B, et al. Among authors: michalski b. Neuroscience. 2002;115(4):1295-308. doi: 10.1016/s0306-4522(02)00384-6. Neuroscience. 2002. PMID: 12453498
Neurotrophic factors and Alzheimer's disease: are we focusing on the wrong molecule?
Fahnestock M, Garzon D, Holsinger RM, Michalski B. Fahnestock M, et al. Among authors: michalski b. J Neural Transm Suppl. 2002;(62):241-52. doi: 10.1007/978-3-7091-6139-5_22. J Neural Transm Suppl. 2002. PMID: 12456067
Pro-brain-derived neurotrophic factor is decreased in parietal cortex in Alzheimer's disease.
Michalski B, Fahnestock M. Michalski B, et al. Brain Res Mol Brain Res. 2003 Mar 17;111(1-2):148-54. doi: 10.1016/s0169-328x(03)00003-2. Brain Res Mol Brain Res. 2003. PMID: 12654514
The nerve growth factor precursor proNGF exhibits neurotrophic activity but is less active than mature nerve growth factor.
Fahnestock M, Yu G, Michalski B, Mathew S, Colquhoun A, Ross GM, Coughlin MD. Fahnestock M, et al. Among authors: michalski b. J Neurochem. 2004 May;89(3):581-92. doi: 10.1111/j.1471-4159.2004.02360.x. J Neurochem. 2004. PMID: 15086515
The effects of brain-derived neurotrophic factor (BDNF) administration on kindling induction, Trk expression and seizure-related morphological changes.
Xu B, Michalski B, Racine RJ, Fahnestock M. Xu B, et al. Among authors: michalski b. Neuroscience. 2004;126(3):521-31. doi: 10.1016/j.neuroscience.2004.03.044. Neuroscience. 2004. PMID: 15183502
NT-3 modulates BDNF and proBDNF levels in naïve and kindled rat hippocampus.
Ullal GR, Michalski B, Xu B, Racine RJ, Fahnestock M. Ullal GR, et al. Among authors: michalski b. Neurochem Int. 2007 May;50(6):866-71. doi: 10.1016/j.neuint.2007.02.009. Epub 2007 Mar 7. Neurochem Int. 2007. PMID: 17462792
Long-term changes in neurotrophic factor expression in distal nerve stump following denervation and reinnervation with motor or sensory nerve.
Michalski B, Bain JR, Fahnestock M. Michalski B, et al. J Neurochem. 2008 May;105(4):1244-52. doi: 10.1111/j.1471-4159.2008.05224.x. Epub 2008 Jan 10. J Neurochem. 2008. PMID: 18194437 Free PMC article.
BDNF increases with behavioral enrichment and an antioxidant diet in the aged dog.
Fahnestock M, Marchese M, Head E, Pop V, Michalski B, Milgram WN, Cotman CW. Fahnestock M, et al. Among authors: michalski b. Neurobiol Aging. 2012 Mar;33(3):546-54. doi: 10.1016/j.neurobiolaging.2010.03.019. Epub 2010 May 5. Neurobiol Aging. 2012. PMID: 20447733 Free PMC article.
Nerve growth factor promoter activity revealed in mice expressing enhanced green fluorescent protein.
Kawaja MD, Smithson LJ, Elliott J, Trinh G, Crotty AM, Michalski B, Fahnestock M. Kawaja MD, et al. Among authors: michalski b. J Comp Neurol. 2011 Sep 1;519(13):2522-45. doi: 10.1002/cne.22629. J Comp Neurol. 2011. PMID: 21456011 Free PMC article.
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