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104 results
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Agonist potency at P2X7 receptors is modulated by structurally diverse lipids.
Michel AD, Fonfria E. Michel AD, et al. Br J Pharmacol. 2007 Oct;152(4):523-37. doi: 10.1038/sj.bjp.0707417. Epub 2007 Aug 13. Br J Pharmacol. 2007. PMID: 17700717 Free PMC article.
Disruption of the P2X7 purinoceptor gene abolishes chronic inflammatory and neuropathic pain.
Chessell IP, Hatcher JP, Bountra C, Michel AD, Hughes JP, Green P, Egerton J, Murfin M, Richardson J, Peck WL, Grahames CB, Casula MA, Yiangou Y, Birch R, Anand P, Buell GN. Chessell IP, et al. Among authors: michel ad. Pain. 2005 Apr;114(3):386-96. doi: 10.1016/j.pain.2005.01.002. Pain. 2005. PMID: 15777864
Decavanadate, a P2X receptor antagonist, and its use to study ligand interactions with P2X7 receptors.
Michel AD, Xing M, Thompson KM, Jones CA, Humphrey PP. Michel AD, et al. Eur J Pharmacol. 2006 Mar 18;534(1-3):19-29. doi: 10.1016/j.ejphar.2006.01.009. Epub 2006 Feb 17. Eur J Pharmacol. 2006. PMID: 16487507
Identification of 2-oxo-N-(phenylmethyl)-4-imidazolidinecarboxamide antagonists of the P2X(7) receptor.
Abberley L, Bebius A, Beswick PJ, Billinton A, Collis KL, Dean DK, Fonfria E, Gleave RJ, Medhurst SJ, Michel AD, Moses AP, Patel S, Roman SA, Scoccitti T, Smith B, Steadman JG, Walter DS. Abberley L, et al. Among authors: michel ad. Bioorg Med Chem Lett. 2010 Nov 15;20(22):6370-4. doi: 10.1016/j.bmcl.2010.09.101. Epub 2010 Sep 22. Bioorg Med Chem Lett. 2010. PMID: 20934331
Discovery and structure-activity relationships of a series of pyroglutamic acid amide antagonists of the P2X7 receptor.
Abdi MH, Beswick PJ, Billinton A, Chambers LJ, Charlton A, Collins SD, Collis KL, Dean DK, Fonfria E, Gleave RJ, Lejeune CL, Livermore DG, Medhurst SJ, Michel AD, Moses AP, Page L, Patel S, Roman SA, Senger S, Slingsby B, Steadman JG, Stevens AJ, Walter DS. Abdi MH, et al. Among authors: michel ad. Bioorg Med Chem Lett. 2010 Sep 1;20(17):5080-4. doi: 10.1016/j.bmcl.2010.07.033. Epub 2010 Jul 14. Bioorg Med Chem Lett. 2010. PMID: 20673717
Synthesis and biological activity of a series of tetrasubstituted-imidazoles as P2X(7) antagonists.
Gleave RJ, Walter DS, Beswick PJ, Fonfria E, Michel AD, Roman SA, Tang SP. Gleave RJ, et al. Among authors: michel ad. Bioorg Med Chem Lett. 2010 Aug 15;20(16):4951-4. doi: 10.1016/j.bmcl.2010.05.018. Epub 2010 Jun 25. Bioorg Med Chem Lett. 2010. PMID: 20634071
Structure-activity relationships and in vivo activity of (1H-pyrazol-4-yl)acetamide antagonists of the P2X(7) receptor.
Beswick PJ, Billinton A, Chambers LJ, Dean DK, Fonfria E, Gleave RJ, Medhurst SJ, Michel AD, Moses AP, Patel S, Roman SA, Roomans S, Senger S, Stevens AJ, Walter DS. Beswick PJ, et al. Among authors: michel ad. Bioorg Med Chem Lett. 2010 Aug 1;20(15):4653-6. doi: 10.1016/j.bmcl.2010.05.107. Epub 2010 Jun 8. Bioorg Med Chem Lett. 2010. PMID: 20579878
Synthesis and structure-activity relationships of a series of (1H-pyrazol-4-yl)acetamide antagonists of the P2X7 receptor.
Chambers LJ, Stevens AJ, Moses AP, Michel AD, Walter DS, Davies DJ, Livermore DG, Fonfria E, Demont EH, Vimal M, Theobald PJ, Beswick PJ, Gleave RJ, Roman SA, Senger S. Chambers LJ, et al. Among authors: michel ad. Bioorg Med Chem Lett. 2010 May 15;20(10):3161-4. doi: 10.1016/j.bmcl.2010.03.096. Epub 2010 Mar 30. Bioorg Med Chem Lett. 2010. PMID: 20399651
Mechanism of action of species-selective P2X(7) receptor antagonists.
Michel AD, Ng SW, Roman S, Clay WC, Dean DK, Walter DS. Michel AD, et al. Br J Pharmacol. 2009 Apr;156(8):1312-25. doi: 10.1111/j.1476-5381.2009.00135.x. Epub 2009 Mar 20. Br J Pharmacol. 2009. PMID: 19309360 Free PMC article.
Identification of novel glycine sulfonamide antagonists for the EP1 receptor.
McKeown SC, Hall A, Blunt R, Brown SH, Chessell IP, Chowdhury A, Giblin GM, Healy MP, Johnson MR, Lorthioir O, Michel AD, Naylor A, Lewell X, Roman S, Watson SP, Winchester WJ, Wilson RJ. McKeown SC, et al. Among authors: michel ad. Bioorg Med Chem Lett. 2007 Mar 15;17(6):1750-4. doi: 10.1016/j.bmcl.2006.12.060. Epub 2006 Dec 22. Bioorg Med Chem Lett. 2007. PMID: 17236765
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