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NAFLD, NASH and liver cancer.
Michelotti GA, Machado MV, Diehl AM. Michelotti GA, et al. Nat Rev Gastroenterol Hepatol. 2013 Nov;10(11):656-65. doi: 10.1038/nrgastro.2013.183. Epub 2013 Oct 1. Nat Rev Gastroenterol Hepatol. 2013. PMID: 24080776 Review.
Osteopontin is induced by hedgehog pathway activation and promotes fibrosis progression in nonalcoholic steatohepatitis.
Syn WK, Choi SS, Liaskou E, Karaca GF, Agboola KM, Oo YH, Mi Z, Pereira TA, Zdanowicz M, Malladi P, Chen Y, Moylan C, Jung Y, Bhattacharya SD, Teaberry V, Omenetti A, Abdelmalek MF, Guy CD, Adams DH, Kuo PC, Michelotti GA, Whitington PF, Diehl AM. Syn WK, et al. Among authors: michelotti ga. Hepatology. 2011 Jan;53(1):106-15. doi: 10.1002/hep.23998. Epub 2010 Oct 21. Hepatology. 2011. PMID: 20967826 Free PMC article.
Hedgehog signaling in the liver.
Omenetti A, Choi S, Michelotti G, Diehl AM. Omenetti A, et al. J Hepatol. 2011 Feb;54(2):366-73. doi: 10.1016/j.jhep.2010.10.003. Epub 2010 Oct 14. J Hepatol. 2011. PMID: 21093090 Free PMC article. Review.
Hedgehog signaling antagonist promotes regression of both liver fibrosis and hepatocellular carcinoma in a murine model of primary liver cancer.
Philips GM, Chan IS, Swiderska M, Schroder VT, Guy C, Karaca GF, Moylan C, Venkatraman T, Feuerlein S, Syn WK, Jung Y, Witek RP, Choi S, Michelotti GA, Rangwala F, Merkle E, Lascola C, Diehl AM. Philips GM, et al. Among authors: michelotti ga. PLoS One. 2011;6(9):e23943. doi: 10.1371/journal.pone.0023943. Epub 2011 Sep 2. PLoS One. 2011. PMID: 21912653 Free PMC article.
NKT-associated hedgehog and osteopontin drive fibrogenesis in non-alcoholic fatty liver disease.
Syn WK, Agboola KM, Swiderska M, Michelotti GA, Liaskou E, Pang H, Xie G, Philips G, Chan IS, Karaca GF, Pereira Tde A, Chen Y, Mi Z, Kuo PC, Choi SS, Guy CD, Abdelmalek MF, Diehl AM. Syn WK, et al. Among authors: michelotti ga. Gut. 2012 Sep;61(9):1323-9. doi: 10.1136/gutjnl-2011-301857. Epub 2012 Mar 17. Gut. 2012. PMID: 22427237 Free PMC article.
Paracrine Hedgehog signaling drives metabolic changes in hepatocellular carcinoma.
Chan IS, Guy CD, Chen Y, Lu J, Swiderska-Syn M, Michelotti GA, Karaca G, Xie G, Krüger L, Syn WK, Anderson BR, Pereira TA, Choi SS, Baldwin AS, Diehl AM. Chan IS, et al. Among authors: michelotti ga. Cancer Res. 2012 Dec 15;72(24):6344-50. doi: 10.1158/0008-5472.CAN-12-1068. Epub 2012 Oct 12. Cancer Res. 2012. PMID: 23066040 Free PMC article.
Smoothened is a master regulator of adult liver repair.
Michelotti GA, Xie G, Swiderska M, Choi SS, Karaca G, Krüger L, Premont R, Yang L, Syn WK, Metzger D, Diehl AM. Michelotti GA, et al. J Clin Invest. 2013 Jun;123(6):2380-94. doi: 10.1172/JCI66904. J Clin Invest. 2013. PMID: 23563311 Free PMC article.
76 results