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P2Y12 antagonism: promises and challenges.
Michelson AD. Michelson AD. Arterioscler Thromb Vasc Biol. 2008 Mar;28(3):s33-8. doi: 10.1161/ATVBAHA.107.160689. Epub 2008 Jan 3. Arterioscler Thromb Vasc Biol. 2008. PMID: 18174449 Review.
Clopidogrel pharmacokinetics and pharmacodynamics vary widely despite exclusion or control of polymorphisms (CYP2C19, ABCB1, PON1), noncompliance, diet, smoking, co-medications (including proton pump inhibitors), and pre-existent variability in platelet function.
Frelinger AL 3rd, Bhatt DL, Lee RD, Mulford DJ, Wu J, Nudurupati S, Nigam A, Lampa M, Brooks JK, Barnard MR, Michelson AD. Frelinger AL 3rd, et al. J Am Coll Cardiol. 2013 Feb 26;61(8):872-9. doi: 10.1016/j.jacc.2012.11.040. Epub 2013 Jan 16. J Am Coll Cardiol. 2013. PMID: 23333143 Clinical Trial.
Antiplatelet activity, P2Y₁ and P2Y₁₂ inhibition, and metabolism in plasma of stereoisomers of diadenosine 5',5'″-P¹ ,P⁴-dithio-P²,P³-chloromethylenetetraphosphate.
Chang H, Yanachkov IB, Dix EJ, Yanachkova M, Li Y, Barnard MR, Wright GE, Michelson AD, Frelinger AL 3rd. Chang H, et al. PLoS One. 2014 Apr 10;9(4):e94780. doi: 10.1371/journal.pone.0094780. eCollection 2014. PLoS One. 2014. PMID: 24722456 Free PMC article.
Synergistic Inhibition of Both P2Y1 and P2Y12 Adenosine Diphosphate Receptors As Novel Approach to Rapidly Attenuate Platelet-Mediated Thrombosis.
Gremmel T, Yanachkov IB, Yanachkova MI, Wright GE, Wider J, Undyala VV, Michelson AD, Frelinger AL 3rd, Przyklenk K. Gremmel T, et al. Arterioscler Thromb Vasc Biol. 2016 Mar;36(3):501-9. doi: 10.1161/ATVBAHA.115.306885. Epub 2016 Jan 7. Arterioscler Thromb Vasc Biol. 2016. PMID: 26743169 Free PMC article.
New highly active antiplatelet agents with dual specificity for platelet P2Y1 and P2Y12 adenosine diphosphate receptors.
Yanachkov IB, Chang H, Yanachkova MI, Dix EJ, Berny-Lang MA, Gremmel T, Michelson AD, Wright GE, Frelinger AL 3rd. Yanachkov IB, et al. Eur J Med Chem. 2016 Jan 1;107:204-18. doi: 10.1016/j.ejmech.2015.10.055. Epub 2015 Nov 9. Eur J Med Chem. 2016. PMID: 26588064 Free PMC article.
How I use laboratory monitoring of antiplatelet therapy.
Michelson AD, Bhatt DL. Michelson AD, et al. Blood. 2017 Aug 10;130(6):713-721. doi: 10.1182/blood-2017-03-742338. Epub 2017 Jun 9. Blood. 2017. PMID: 28600334 Review.
GLS-409, an Antagonist of Both P2Y1 and P2Y12, Potently Inhibits Canine Coronary Artery Thrombosis and Reversibly Inhibits Human Platelet Activation.
Smolensky Koganov E, Michelson AD, Yanachkov IB, Yanachkova MI, Wright GE, Przyklenk K, Frelinger AL 3rd. Smolensky Koganov E, et al. Sci Rep. 2018 Sep 28;8(1):14529. doi: 10.1038/s41598-018-32797-1. Sci Rep. 2018. PMID: 30266987 Free PMC article.
Soluble CD40 Ligand in Aspirin-Treated Patients Undergoing Cardiac Catheterization.
Gremmel T, Frelinger AL 3rd, Michelson AD. Gremmel T, et al. PLoS One. 2015 Aug 3;10(8):e0134599. doi: 10.1371/journal.pone.0134599. eCollection 2015. PLoS One. 2015. PMID: 26237513 Free PMC article.
Diabetes mellitus, CYP2C19 genotype, and response to escalating doses of clopidogrel. Insights from the ELEVATE-TIMI 56 Trial.
Carreras ET, Hochholzer W, Frelinger AL 3rd, Nordio F, O'Donoghue ML, Wiviott SD, Angiolillo DJ, Michelson AD, Sabatine MS, Mega JL. Carreras ET, et al. Thromb Haemost. 2016 Jul 4;116(1):69-77. doi: 10.1160/TH15-12-0981. Epub 2016 Mar 24. Thromb Haemost. 2016. PMID: 27009617 Clinical Trial.
A randomized, 2-period, crossover design study to assess the effects of dexlansoprazole, lansoprazole, esomeprazole, and omeprazole on the steady-state pharmacokinetics and pharmacodynamics of clopidogrel in healthy volunteers.
Frelinger AL 3rd, Lee RD, Mulford DJ, Wu J, Nudurupati S, Nigam A, Brooks JK, Bhatt DL, Michelson AD. Frelinger AL 3rd, et al. J Am Coll Cardiol. 2012 Apr 3;59(14):1304-11. doi: 10.1016/j.jacc.2011.12.024. J Am Coll Cardiol. 2012. PMID: 22464259 Clinical Trial.
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