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Tumour hypoxia affects the responsiveness of cancer cells to chemotherapy and promotes cancer progression.
Cosse JP, Michiels C. Cosse JP, et al. Among authors: michiels c. Anticancer Agents Med Chem. 2008 Oct;8(7):790-7. doi: 10.2174/187152008785914798. Anticancer Agents Med Chem. 2008. PMID: 18855580 Review.
Identification of the phospholipase A(2) isoforms that contribute to arachidonic acid release in hypoxic endothelial cells: limits of phospholipase A(2) inhibitors.
Michiels C, Renard P, Bouaziz N, Heck N, Eliaers F, Ninane N, Quarck R, Holvoet P, Raes M. Michiels C, et al. Biochem Pharmacol. 2002 Jan 15;63(2):321-32. doi: 10.1016/s0006-2952(01)00832-2. Biochem Pharmacol. 2002. PMID: 11841807
Is HIF-1alpha a pro- or an anti-apoptotic protein?
Piret JP, Mottet D, Raes M, Michiels C. Piret JP, et al. Among authors: michiels c. Biochem Pharmacol. 2002 Sep;64(5-6):889-92. doi: 10.1016/s0006-2952(02)01155-3. Biochem Pharmacol. 2002. PMID: 12213583 Review.
Site-directed mutagenesis studies of the hypoxia-inducible factor-1alpha DNA-binding domain.
Michel G, Minet E, Mottet D, Remacle J, Michiels C. Michel G, et al. Among authors: michiels c. Biochim Biophys Acta. 2002 Oct 11;1578(1-3):73-83. doi: 10.1016/s0167-4781(02)00484-0. Biochim Biophys Acta. 2002. PMID: 12393189
Regulation of gene expression by oxygen: NF-kappaB and HIF-1, two extremes.
Michiels C, Minet E, Mottet D, Raes M. Michiels C, et al. Free Radic Biol Med. 2002 Nov 1;33(9):1231-42. doi: 10.1016/s0891-5849(02)01045-6. Free Radic Biol Med. 2002. PMID: 12398931 Review.
Role of ERK and calcium in the hypoxia-induced activation of HIF-1.
Mottet D, Michel G, Renard P, Ninane N, Raes M, Michiels C. Mottet D, et al. Among authors: michiels c. J Cell Physiol. 2003 Jan;194(1):30-44. doi: 10.1002/jcp.10176. J Cell Physiol. 2003. PMID: 12447987
CoCl2, a chemical inducer of hypoxia-inducible factor-1, and hypoxia reduce apoptotic cell death in hepatoma cell line HepG2.
Piret JP, Mottet D, Raes M, Michiels C. Piret JP, et al. Among authors: michiels c. Ann N Y Acad Sci. 2002 Nov;973:443-7. doi: 10.1111/j.1749-6632.2002.tb04680.x. Ann N Y Acad Sci. 2002. PMID: 12485908
ERK and calcium in activation of HIF-1.
Mottet D, Michel G, Renard P, Ninane N, Raes M, Michiels C. Mottet D, et al. Among authors: michiels c. Ann N Y Acad Sci. 2002 Nov;973:448-53. doi: 10.1111/j.1749-6632.2002.tb04681.x. Ann N Y Acad Sci. 2002. PMID: 12485909
Regulation of hypoxia-inducible factor-1alpha protein level during hypoxic conditions by the phosphatidylinositol 3-kinase/Akt/glycogen synthase kinase 3beta pathway in HepG2 cells.
Mottet D, Dumont V, Deccache Y, Demazy C, Ninane N, Raes M, Michiels C. Mottet D, et al. Among authors: michiels c. J Biol Chem. 2003 Aug 15;278(33):31277-85. doi: 10.1074/jbc.M300763200. Epub 2003 May 22. J Biol Chem. 2003. PMID: 12764143
Mitochondria permeability transition-dependent tert-butyl hydroperoxide-induced apoptosis in hepatoma HepG2 cells.
Piret JP, Arnould T, Fuks B, Chatelain P, Remacle J, Michiels C. Piret JP, et al. Among authors: michiels c. Biochem Pharmacol. 2004 Feb 15;67(4):611-20. doi: 10.1016/j.bcp.2003.09.026. Biochem Pharmacol. 2004. PMID: 14757161
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