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Effect of kava and valerian on human physiological and psychological responses to mental stress assessed under laboratory conditions.
Cropley M, Cave Z, Ellis J, Middleton RW. Cropley M, et al. Among authors: middleton rw. Phytother Res. 2002 Feb;16(1):23-7. doi: 10.1002/ptr.1002. Phytother Res. 2002. PMID: 11807960 Clinical Trial.
Artichoke leaf extract (Cynara scolymus) reduces plasma cholesterol in otherwise healthy hypercholesterolemic adults: a randomized, double blind placebo controlled trial.
Bundy R, Walker AF, Middleton RW, Wallis C, Simpson HC. Bundy R, et al. Among authors: middleton rw. Phytomedicine. 2008 Sep;15(9):668-75. doi: 10.1016/j.phymed.2008.03.001. Phytomedicine. 2008. PMID: 18424099 Clinical Trial.
Artichoke leaf extract reduces mild dyspepsia in an open study.
Marakis G, Walker AF, Middleton RW, Booth JC, Wright J, Pike DJ. Marakis G, et al. Among authors: middleton rw. Phytomedicine. 2002 Dec;9(8):694-9. doi: 10.1078/094471102321621287. Phytomedicine. 2002. PMID: 12587688 Clinical Trial.
Bromelain reduces mild acute knee pain and improves well-being in a dose-dependent fashion in an open study of otherwise healthy adults.
Walker AF, Bundy R, Hicks SM, Middleton RW. Walker AF, et al. Among authors: middleton rw. Phytomedicine. 2002 Dec;9(8):681-6. doi: 10.1078/094471102321621269. Phytomedicine. 2002. PMID: 12587686 Clinical Trial.
Artichoke leaf extract reduces symptoms of irritable bowel syndrome in a post-marketing surveillance study.
Walker AF, Middleton RW, Petrowicz O. Walker AF, et al. Among authors: middleton rw. Phytother Res. 2001 Feb;15(1):58-61. doi: 10.1002/1099-1573(200102)15:1<58::aid-ptr805>3.0.co;2-r. Phytother Res. 2001. PMID: 11180525
Artichoke leaf extract reduces symptoms of irritable bowel syndrome and improves quality of life in otherwise healthy volunteers suffering from concomitant dyspepsia: a subset analysis.
Bundy R, Walker AF, Middleton RW, Marakis G, Booth JC. Bundy R, et al. Among authors: middleton rw. J Altern Complement Med. 2004 Aug;10(4):667-9. doi: 10.1089/acm.2004.10.667. J Altern Complement Med. 2004. PMID: 15353023
Turmeric extract may improve irritable bowel syndrome symptomology in otherwise healthy adults: a pilot study.
Bundy R, Walker AF, Middleton RW, Booth J. Bundy R, et al. Among authors: middleton rw. J Altern Complement Med. 2004 Dec;10(6):1015-8. doi: 10.1089/acm.2004.10.1015. J Altern Complement Med. 2004. PMID: 15673996 Clinical Trial.
The significance of "nonsignificance" in randomized controlled studies: a discussion inspired by a double-blinded study on St. John's wort (Hypericum perforatum L.) for premenstrual symptoms.
Hicks SM, Walker AF, Gallagher J, Middleton RW, Wright J. Hicks SM, et al. Among authors: middleton rw. J Altern Complement Med. 2004 Dec;10(6):925-32. doi: 10.1089/acm.2004.10.925. J Altern Complement Med. 2004. PMID: 15673985 Clinical Trial.
Bioreductive fluorescent markers for hypoxic cells: a study of 2-nitroimidazoles with 1-substituents containing fluorescent, bridgehead-nitrogen, bicyclic systems.
Hodgkiss RJ, Middleton RW, Parrick J, Rami HK, Wardman P, Wilson GD. Hodgkiss RJ, et al. Among authors: middleton rw. J Med Chem. 1992 May 15;35(10):1920-6. doi: 10.1021/jm00088a030. J Med Chem. 1992. PMID: 1588568
Fluorescent markers for hypoxic cells: a study of nitroaromatic compounds, with fluorescent heterocyclic side chains, that undergo bioreductive binding.
Hodgkiss RJ, Jones GW, Long A, Middleton RW, Parrick J, Stratford MR, Wardman P, Wilson GD. Hodgkiss RJ, et al. Among authors: middleton rw. J Med Chem. 1991 Jul;34(7):2268-74. doi: 10.1021/jm00111a049. J Med Chem. 1991. PMID: 2066999
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