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Restoration of the CD4 T cell compartment after long-term highly active antiretroviral therapy without phenotypical signs of accelerated immunological aging.
Vrisekoop N, van Gent R, de Boer AB, Otto SA, Borleffs JC, Steingrover R, Prins JM, Kuijpers TW, Wolfs TF, Geelen SP, Vulto I, Lansdorp P, Tesselaar K, Borghans JA, Miedema F. Vrisekoop N, et al. Among authors: miedema f. J Immunol. 2008 Jul 15;181(2):1573-81. doi: 10.4049/jimmunol.181.2.1573. J Immunol. 2008. PMID: 18606713
Maintenance of peripheral naive T cells is sustained by thymus output in mice but not humans.
den Braber I, Mugwagwa T, Vrisekoop N, Westera L, Mögling R, de Boer AB, Willems N, Schrijver EH, Spierenburg G, Gaiser K, Mul E, Otto SA, Ruiter AF, Ackermans MT, Miedema F, Borghans JA, de Boer RJ, Tesselaar K. den Braber I, et al. Among authors: miedema f. Immunity. 2012 Feb 24;36(2):288-97. doi: 10.1016/j.immuni.2012.02.006. Immunity. 2012. PMID: 22365666
Thymic output: a bad TREC record.
Hazenberg MD, Borghans JA, de Boer RJ, Miedema F. Hazenberg MD, et al. Among authors: miedema f. Nat Immunol. 2003 Feb;4(2):97-9. doi: 10.1038/ni0203-97. Nat Immunol. 2003. PMID: 12555089 Review. No abstract available.
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