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Mifepristone and misoprostol versus misoprostol alone for uterine evacuation after early pregnancy failure: study protocol for a randomized double blinded placebo-controlled comparison (Triple M Trial).
van den Berg J, Hamel CC, Snijders MP, Coppus SF, Vandenbussche FP. van den Berg J, et al. BMC Pregnancy Childbirth. 2019 Nov 27;19(1):443. doi: 10.1186/s12884-019-2497-y. BMC Pregnancy Childbirth. 2019. PMID: 31775677 Free PMC article.
BACKGROUND: Early pregnancy failure (EPF) is a common complication of pregnancy. If women do not abort spontaneously, they will undergo medical or surgical treatment in order to remove the products of conception from the uterus. ...Misoprostol treatmen …
BACKGROUND: Early pregnancy failure (EPF) is a common complication of pregnancy. If women do not abort spontaneously, t …
Mifepristone-misoprostol combination treatment for early pregnancy loss after embryo transfer: a case series.
Esposito L, Kornfield MS, Rubin E, O'Leary T, Amato P, Lee D, Wu D, Krieg S, Parker PB. Esposito L, et al. F S Rep. 2023 Jan 20;4(1):93-97. doi: 10.1016/j.xfre.2023.01.003. eCollection 2023 Mar. F S Rep. 2023. PMID: 36959956 Free PMC article.
OBJECTIVE: Evidence strongly supports the use of mifepristone-misoprostol combination treatment for early pregnancy loss (EPL) among pregnancies conceived without assisted reproductive technologies. ...Future, larger-scale studies are needed com …
OBJECTIVE: Evidence strongly supports the use of mifepristone-misoprostol combination treatment for early pregnancy …
Treatment of Early Pregnancy Loss With Mifepristone and Misoprostol Compared With Misoprostol Only.
Friedman M, Mor L, Shazar R, Paul N, Kerner R, Keidar R, Sagiv R, Gluck O. Friedman M, et al. Obstet Gynecol. 2025 Feb 1;145(2):204-209. doi: 10.1097/AOG.0000000000005800. Epub 2024 Dec 5. Obstet Gynecol. 2025. PMID: 39637386
OBJECTIVE: To compare the rates of treatment failure in cases of early pregnancy loss between mifepristone-misoprostol and misoprostol only. METHODS: This retrospective cohort study included patients who received medical treatment for …
OBJECTIVE: To compare the rates of treatment failure in cases of early pregnancy loss between mifepristone-mi …
Early pregnancy loss medical management in clinical practice.
Baker CC, Wu BT, Han G, Flynn AN, Creinin MD. Baker CC, et al. Contraception. 2023 Oct;126:110134. doi: 10.1016/j.contraception.2023.110134. Epub 2023 Jul 29. Contraception. 2023. PMID: 37524147 Free article. Review.
OBJECTIVES: This study aimed to review clinical practice outcomes of early pregnancy loss (EPL) medical management using mifepristone and misoprostol outside of a clinical trial setting. ...CONCLUSIONS: Outside of a clinical trial setting, medic …
OBJECTIVES: This study aimed to review clinical practice outcomes of early pregnancy loss (EPL) medical management usin …
The Success of Mifepristone and Misoprostol in the Management of Early Pregnancy Loss at a Community Hospital: A Prospective Study.
Farooqi S, Lackie E, Pham A, Zolis L, Sharma K, Devarajan K, Smith K, Nevin-Lam A, Lee S, Tempest H, Mei-Dan E, Tunde-Byass M. Farooqi S, et al. J Obstet Gynaecol Can. 2024 Sep;46(9):102604. doi: 10.1016/j.jogc.2024.102604. Epub 2024 Jun 29. J Obstet Gynaecol Can. 2024. PMID: 38950878 Free article.
OBJECTIVES: This prospective single-arm study was conducted to understand the expulsion rate of the gestational sac in the management of early pregnancy loss (EPL). METHODS: We recruited 441 participants; 188 met the eligibility criteria. ...Participants were …
OBJECTIVES: This prospective single-arm study was conducted to understand the expulsion rate of the gestational sac in the management of …
Mifepristone and misoprostol for early pregnancy failure: a cohort analysis.
Kollitz KM, Meyn LA, Lohr PA, Creinin MD. Kollitz KM, et al. Am J Obstet Gynecol. 2011 May;204(5):386.e1-6. doi: 10.1016/j.ajog.2010.12.026. Epub 2011 Feb 8. Am J Obstet Gynecol. 2011. PMID: 21306697
OBJECTIVE: We sought to examine outcomes of mifepristone and misoprostol for early pregnancy failure (EPF) treatment in a nonresearch setting. STUDY DESIGN: A protocol was developed for physicians to use mifepristone 200 mg orally and …
OBJECTIVE: We sought to examine outcomes of mifepristone and misoprostol for early pregnancy failure (EPF) treat …
The Success of Mifepristone and Misoprostol in the Management of Early Pregnancy Loss at a Community Hospital: A Prospective Study.
Farooqi S, Lackie E, Pham A, Zolis L, Sharma K, Devarajan K, Smith K, Nevin-Lam A, Lee S, Tempest H, Mei-Dan E, Tunde-Byass M. Farooqi S, et al. J Obstet Gynaecol Can. 2025 Jun;47 Suppl 1:102968. doi: 10.1016/j.jogc.2025.102968. J Obstet Gynaecol Can. 2025. PMID: 40602988 Free article.
OBJECTIVES: This prospective single-arm study was conducted to understand the expulsion rate of the gestational sac in the management of early pregnancy loss (EPL). METHODS: We recruited 441 participants; 188 met the eligibility criteria. ...Participants were …
OBJECTIVES: This prospective single-arm study was conducted to understand the expulsion rate of the gestational sac in the management of …
Advances in the management of early pregnancy loss.
Henkel A, Shaw KA. Henkel A, et al. Curr Opin Obstet Gynecol. 2018 Dec;30(6):419-424. doi: 10.1097/GCO.0000000000000501. Curr Opin Obstet Gynecol. 2018. PMID: 30299321
PURPOSE OF REVIEW: To describe recent advances in management of early pregnancy loss. RECENT FINDINGS: Addition of mifepristone to current protocols for medical management of miscarriage increases effectiveness of a single dose of misoprostol …
PURPOSE OF REVIEW: To describe recent advances in management of early pregnancy loss. RECENT FINDINGS: Addition of m …
Current and future expectations of mifepristone treatment in early pregnancy failure: a survey among Dutch gynaecologists.
van den Berg J, Hamel CC, Coppus SF, Snijders MP, Vandenbussche FP. van den Berg J, et al. J Obstet Gynaecol. 2019 Oct;39(7):1006-1011. doi: 10.1080/01443615.2019.1602598. Epub 2019 Jun 19. J Obstet Gynaecol. 2019. PMID: 31215270
To investigate the current and future addition of mifepristone to misoprostol treatment in case of early pregnancy failure (EPF), a digital questionnaire was distributed to a representative sample of all Dutch hospitals (25/79). ...Impact Statement Wha …
To investigate the current and future addition of mifepristone to misoprostol treatment in case of early pregnancy …
Mifepristone and misoprostol versus placebo and misoprostol for resolution of miscarriage in women diagnosed with missed miscarriage: the MifeMiso RCT.
Devall A, Chu J, Beeson L, Hardy P, Cheed V, Sun Y, Roberts T, Ogwulu CO, Williams E, Jones L, Papadopoulos JF, Bender-Atik R, Brewin J, Hinshaw K, Choudhary M, Ahmed A, Naftalin J, Nunes N, Oliver A, Izzat F, Bhatia K, Hassan I, Jeve Y, Hamilton J, Deb S, Bottomley C, Ross J, Watkins L, Underwood M, Cheong Y, Kumar C, Gupta P, Small R, Pringle S, Hodge F, Shahid A, Gallos I, Horne A, Quenby S, Coomarasamy A. Devall A, et al. Health Technol Assess. 2021 Nov;25(68):1-114. doi: 10.3310/hta25680. Health Technol Assess. 2021. PMID: 34821547 Free article. Clinical Trial.
In total, 711 women were randomised to receive either mifepristone plus misoprostol or placebo plus misoprostol. Overall, 83% of women who received mifepristone plus misoprostol had miscarriage resolution within 7 days, compared with 76% of the …
In total, 711 women were randomised to receive either mifepristone plus misoprostol or placebo plus misoprostol. Overal …
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