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Neurons derived from sporadic Alzheimer's disease iPSCs reveal elevated TAU hyperphosphorylation, increased amyloid levels, and GSK3B activation.
Ochalek A, Mihalik B, Avci HX, Chandrasekaran A, Téglási A, Bock I, Giudice ML, Táncos Z, Molnár K, László L, Nielsen JE, Holst B, Freude K, Hyttel P, Kobolák J, Dinnyés A. Ochalek A, et al. Among authors: mihalik b. Alzheimers Res Ther. 2017 Dec 1;9(1):90. doi: 10.1186/s13195-017-0317-z. Alzheimers Res Ther. 2017. PMID: 29191219 Free PMC article.
The EU-ToxRisk method documentation, data processing and chemical testing pipeline for the regulatory use of new approach methods.
Krebs A, van Vugt-Lussenburg BMA, Waldmann T, Albrecht W, Boei J, Ter Braak B, Brajnik M, Braunbeck T, Brecklinghaus T, Busquet F, Dinnyes A, Dokler J, Dolde X, Exner TE, Fisher C, Fluri D, Forsby A, Hengstler JG, Holzer AK, Janstova Z, Jennings P, Kisitu J, Kobolak J, Kumar M, Limonciel A, Lundqvist J, Mihalik B, Moritz W, Pallocca G, Ulloa APC, Pastor M, Rovida C, Sarkans U, Schimming JP, Schmidt BZ, Stöber R, Strassfeld T, van de Water B, Wilmes A, van der Burg B, Verfaillie CM, von Hellfeld R, Vrieling H, Vrijenhoek NG, Leist M. Krebs A, et al. Among authors: mihalik b. Arch Toxicol. 2020 Jul;94(7):2435-2461. doi: 10.1007/s00204-020-02802-6. Epub 2020 Jul 6. Arch Toxicol. 2020. PMID: 32632539 Free PMC article.
Selective inhibition of extra-synaptic α5-GABAA receptors by S44819, a new therapeutic agent.
Etherington LA, Mihalik B, Pálvölgyi A, Ling I, Pallagi K, Kertész S, Varga P, Gunn BG, Brown AR, Livesey MR, Monteiro O, Belelli D, Barkóczy J, Spedding M, Gacsályi I, Antoni FA, Lambert JJ. Etherington LA, et al. Among authors: mihalik b. Neuropharmacology. 2017 Oct;125:353-364. doi: 10.1016/j.neuropharm.2017.08.012. Epub 2017 Aug 12. Neuropharmacology. 2017. PMID: 28807671
A novel GABA(A) alpha 5 receptor inhibitor with therapeutic potential.
Ling I, Mihalik B, Etherington LA, Kapus G, Pálvölgyi A, Gigler G, Kertész S, Gaál A, Pallagi K, Kiricsi P, Szabó É, Szénási G, Papp L, Hársing LG, Lévay G, Spedding M, Lambert JJ, Belelli D, Barkóczy J, Volk B, Simig G, Gacsályi I, Antoni FA. Ling I, et al. Among authors: mihalik b. Eur J Pharmacol. 2015 Oct 5;764:497-507. doi: 10.1016/j.ejphar.2015.07.005. Epub 2015 Jul 11. Eur J Pharmacol. 2015. PMID: 26169564
Loop F of the GABAA receptor alpha subunit governs GABA potency.
Pálvölgyi A, Móricz K, Pataki Á, Mihalik B, Gigler G, Megyeri K, Udvari S, Gacsályi I, Antoni FA. Pálvölgyi A, et al. Among authors: mihalik b. Neuropharmacology. 2018 Jan;128:408-415. doi: 10.1016/j.neuropharm.2017.10.042. Epub 2017 Nov 3. Neuropharmacology. 2018. PMID: 29109059
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