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Immunotherapy with engineered bacteria by targeting the STING pathway for anti-tumor immunity.
Leventhal DS, Sokolovska A, Li N, Plescia C, Kolodziej SA, Gallant CW, Christmas R, Gao JR, James MJ, Abin-Fuentes A, Momin M, Bergeron C, Fisher A, Miller PF, West KA, Lora JM. Leventhal DS, et al. Among authors: miller pf. Nat Commun. 2020 Jun 1;11(1):2739. doi: 10.1038/s41467-020-16602-0. Nat Commun. 2020. PMID: 32483165 Free PMC article.
An engineered E. coli Nissle improves hyperammonemia and survival in mice and shows dose-dependent exposure in healthy humans.
Kurtz CB, Millet YA, Puurunen MK, Perreault M, Charbonneau MR, Isabella VM, Kotula JW, Antipov E, Dagon Y, Denney WS, Wagner DA, West KA, Degar AJ, Brennan AM, Miller PF. Kurtz CB, et al. Among authors: miller pf. Sci Transl Med. 2019 Jan 16;11(475):eaau7975. doi: 10.1126/scitranslmed.aau7975. Sci Transl Med. 2019. PMID: 30651324 Clinical Trial.
Engineering living therapeutics with synthetic biology.
Cubillos-Ruiz A, Guo T, Sokolovska A, Miller PF, Collins JJ, Lu TK, Lora JM. Cubillos-Ruiz A, et al. Among authors: miller pf. Nat Rev Drug Discov. 2021 Dec;20(12):941-960. doi: 10.1038/s41573-021-00285-3. Epub 2021 Oct 6. Nat Rev Drug Discov. 2021. PMID: 34616030 Review.
In vitro antibacterial activity of AZD0914, a new spiropyrimidinetrione DNA gyrase/topoisomerase inhibitor with potent activity against Gram-positive, fastidious Gram-Negative, and atypical bacteria.
Huband MD, Bradford PA, Otterson LG, Basarab GS, Kutschke AC, Giacobbe RA, Patey SA, Alm RA, Johnstone MR, Potter ME, Miller PF, Mueller JP. Huband MD, et al. Among authors: miller pf. Antimicrob Agents Chemother. 2015 Jan;59(1):467-74. doi: 10.1128/AAC.04124-14. Epub 2014 Nov 10. Antimicrob Agents Chemother. 2015. PMID: 25385112 Free PMC article.
Linezolid, the first oxazolidinone antibacterial agent.
Leach KL, Brickner SJ, Noe MC, Miller PF. Leach KL, et al. Among authors: miller pf. Ann N Y Acad Sci. 2011 Mar;1222:49-54. doi: 10.1111/j.1749-6632.2011.05962.x. Ann N Y Acad Sci. 2011. PMID: 21434942 Review.
53 results