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The antiviral activity of Toll-like receptor 7 and 7/8 agonists.
Miller RL, Meng TC, Tomai MA. Miller RL, et al. Drug News Perspect. 2008 Mar;21(2):69-87. doi: 10.1358/dnp.2008.21.2.1188193. Drug News Perspect. 2008. PMID: 18389099 Review.
Administration of a dual toll-like receptor 7 and toll-like receptor 8 agonist protects against influenza in rats.
Hammerbeck DM, Burleson GR, Schuller CJ, Vasilakos JP, Tomai M, Egging E, Cochran FR, Woulfe S, Miller RL. Hammerbeck DM, et al. Among authors: miller rl. Antiviral Res. 2007 Jan;73(1):1-11. doi: 10.1016/j.antiviral.2006.07.011. Epub 2006 Aug 18. Antiviral Res. 2007. PMID: 16959331
Apoptotic responses in squamous carcinoma and epithelial cells to small-molecule toll-like receptor agonists evaluated with automated cytometry.
Inglefield JR, Larson CJ, Gibson SJ, Lebrec H, Miller RL. Inglefield JR, et al. Among authors: miller rl. J Biomol Screen. 2006 Sep;11(6):575-85. doi: 10.1177/1087057106288051. Epub 2006 Jun 7. J Biomol Screen. 2006. PMID: 16760371
Plasmacytoid dendritic cells produce cytokines and mature in response to the TLR7 agonists, imiquimod and resiquimod.
Gibson SJ, Lindh JM, Riter TR, Gleason RM, Rogers LM, Fuller AE, Oesterich JL, Gorden KB, Qiu X, McKane SW, Noelle RJ, Miller RL, Kedl RM, Fitzgerald-Bocarsly P, Tomai MA, Vasilakos JP. Gibson SJ, et al. Among authors: miller rl. Cell Immunol. 2002 Jul-Aug;218(1-2):74-86. doi: 10.1016/s0008-8749(02)00517-8. Cell Immunol. 2002. PMID: 12470615
Toll-like receptor-7 tolerizes malignant B cells and enhances killing by cytotoxic agents.
Shi Y, White D, He L, Miller RL, Spaner DE. Shi Y, et al. Among authors: miller rl. Cancer Res. 2007 Feb 15;67(4):1823-31. doi: 10.1158/0008-5472.CAN-06-2381. Cancer Res. 2007. PMID: 17308125
Regression of lymphomatous skin deposits in a chronic lymphocytic leukemia patient treated with the Toll-like receptor-7/8 agonist, imiquimod.
Spaner DE, Miller RL, Mena J, Grossman L, Sorrenti V, Shi Y. Spaner DE, et al. Among authors: miller rl. Leuk Lymphoma. 2005 Jun;46(6):935-9. doi: 10.1080/10428190500054426. Leuk Lymphoma. 2005. PMID: 16019542
Imidazoquinoline Toll-like receptor 8 agonists activate human newborn monocytes and dendritic cells through adenosine-refractory and caspase-1-dependent pathways.
Philbin VJ, Dowling DJ, Gallington LC, Cort├ęs G, Tan Z, Suter EE, Chi KW, Shuckett A, Stoler-Barak L, Tomai M, Miller RL, Mansfield K, Levy O. Philbin VJ, et al. Among authors: miller rl. J Allergy Clin Immunol. 2012 Jul;130(1):195-204.e9. doi: 10.1016/j.jaci.2012.02.042. Epub 2012 Apr 21. J Allergy Clin Immunol. 2012. PMID: 22521247 Free PMC article.
Unique efficacy of Toll-like receptor 8 agonists in activating human neonatal antigen-presenting cells.
Levy O, Suter EE, Miller RL, Wessels MR. Levy O, et al. Among authors: miller rl. Blood. 2006 Aug 15;108(4):1284-90. doi: 10.1182/blood-2005-12-4821. Epub 2006 Apr 25. Blood. 2006. PMID: 16638933 Free PMC article.
Microarray analysis of aberrant gene expression in actinic keratosis: effect of the Toll-like receptor-7 agonist imiquimod.
Torres A, Storey L, Anders M, Miller RL, Bulbulian BJ, Jin J, Raghavan S, Lee J, Slade HB, Birmachu W. Torres A, et al. Among authors: miller rl. Br J Dermatol. 2007 Dec;157(6):1132-47. doi: 10.1111/j.1365-2133.2007.08218.x. Epub 2007 Oct 18. Br J Dermatol. 2007. PMID: 17944981 Clinical Trial.
Synthesis and structure-activity-relationships of 1H-imidazo[4,5-c]quinolines that induce interferon production.
Gerster JF, Lindstrom KJ, Miller RL, Tomai MA, Birmachu W, Bomersine SN, Gibson SJ, Imbertson LM, Jacobson JR, Knafla RT, Maye PV, Nikolaides N, Oneyemi FY, Parkhurst GJ, Pecore SE, Reiter MJ, Scribner LS, Testerman TL, Thompson NJ, Wagner TL, Weeks CE, Andre JD, Lagain D, Bastard Y, Lupu M. Gerster JF, et al. Among authors: miller rl. J Med Chem. 2005 May 19;48(10):3481-91. doi: 10.1021/jm049211v. J Med Chem. 2005. PMID: 15887957
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