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Synthetic Heparan Sulfate Mimetic Pixatimod (PG545) Potently Inhibits SARS-CoV-2 by Disrupting the Spike-ACE2 Interaction.
Guimond SE, Mycroft-West CJ, Gandhi NS, Tree JA, Le TT, Spalluto CM, Humbert MV, Buttigieg KR, Coombes N, Elmore MJ, Wand M, Nyström K, Said J, Setoh YX, Amarilla AA, Modhiran N, Sng JDJ, Chhabra M, Young PR, Rawle DJ, Lima MA, Yates EA, Karlsson R, Miller RL, Chen YH, Bagdonaite I, Yang Z, Stewart J, Nguyen D, Laidlaw S, Hammond E, Dredge K, Wilkinson TMA, Watterson D, Khromykh AA, Suhrbier A, Carroll MW, Trybala E, Bergström T, Ferro V, Skidmore MA, Turnbull JE. Guimond SE, et al. Among authors: miller rl. ACS Cent Sci. 2022 May 25;8(5):527-545. doi: 10.1021/acscentsci.1c01293. Epub 2022 Mar 29. ACS Cent Sci. 2022. PMID: 35647275 Free PMC article.
Glycomics profiling of heparan sulfate structure and activity.
Turnbull JE, Miller RL, Ahmed Y, Puvirajesinghe TM, Guimond SE. Turnbull JE, et al. Among authors: miller rl. Methods Enzymol. 2010;480:65-85. doi: 10.1016/S0076-6879(10)80004-7. Methods Enzymol. 2010. PMID: 20816205 Review.
Shotgun ion mobility mass spectrometry sequencing of heparan sulfate saccharides.
Miller RL, Guimond SE, Schwörer R, Zubkova OV, Tyler PC, Xu Y, Liu J, Chopra P, Boons GJ, Grabarics M, Manz C, Hofmann J, Karlsson NG, Turnbull JE, Struwe WB, Pagel K. Miller RL, et al. Nat Commun. 2020 Mar 20;11(1):1481. doi: 10.1038/s41467-020-15284-y. Nat Commun. 2020. PMID: 32198425 Free PMC article.
Dissecting structure-function of 3-O-sulfated heparin and engineered heparan sulfates.
Karlsson R, Chopra P, Joshi A, Yang Z, Vakhrushev SY, Clausen TM, Painter CD, Szekeres GP, Chen YH, Sandoval DR, Hansen L, Esko JD, Pagel K, Dyer DP, Turnbull JE, Clausen H, Boons GJ, Miller RL. Karlsson R, et al. Among authors: miller rl. Sci Adv. 2021 Dec 24;7(52):eabl6026. doi: 10.1126/sciadv.abl6026. Epub 2021 Dec 22. Sci Adv. 2021. PMID: 34936441 Free PMC article.
Chemokine CXCL4 interactions with extracellular matrix proteoglycans mediate widespread immune cell recruitment independent of chemokine receptors.
Gray AL, Karlsson R, Roberts ARE, Ridley AJL, Pun N, Khan B, Lawless C, Luís R, Szpakowska M, Chevigné A, Hughes CE, Medina-Ruiz L, Birchenough HL, Mulholland IZ, Salanga CL, Yates EA, Turnbull JE, Handel TM, Graham GJ, Jowitt TA, Schiessl I, Richter RP, Miller RL, Dyer DP. Gray AL, et al. Among authors: miller rl. Cell Rep. 2023 Jan 31;42(1):111930. doi: 10.1016/j.celrep.2022.111930. Epub 2023 Jan 5. Cell Rep. 2023. PMID: 36640356 Free article.
845 results