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Synthesis and biological activity of CCK heptapeptide analogues. Effects of conformational constraints and standard modifications on receptor subtype selectivity, functional activity in vitro, and appetite suppression in vivo.
Holladay MW, Bennett MJ, Tufano MD, Lin CW, Asin KE, Witte DG, Miller TR, Bianchi BR, Nikkel AL, Bednarz L, et al. Holladay MW, et al. Among authors: miller tr. J Med Chem. 1992 Aug 7;35(16):2919-28. doi: 10.1021/jm00094a001. J Med Chem. 1992. PMID: 1501220
trans-3-n-propyl-L-proline is a highly favorable, conformationally restricted replacement for methionine in the C-terminal tetrapeptide of cholecystokinin. Stereoselective synthesis of 3-allyl- and 3-n-propyl-L-proline derivatives from 4-hydroxy-L-proline.
Holladay MW, Lin CW, May CS, Garvey DS, Witte DG, Miller TR, Wolfram CA, Nadzan AM. Holladay MW, et al. Among authors: miller tr. J Med Chem. 1991 Jan;34(1):455-7. doi: 10.1021/jm00105a068. J Med Chem. 1991. PMID: 1992147 No abstract available.
737 results