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Systemic lupus erythematosus and vaccination.
Millet A, Decaux O, Perlat A, Grosbois B, Jego P. Millet A, et al. Eur J Intern Med. 2009 May;20(3):236-41. doi: 10.1016/j.ejim.2008.07.017. Epub 2008 Aug 29. Eur J Intern Med. 2009. PMID: 19393490 Review.
Preventive vaccination is therefore warranted but has often been withheld owing to fears of a link between infection and autoimmunity, and the possibility of inducing or exacerbating lupus after vaccination. ...
Preventive vaccination is therefore warranted but has often been withheld owing to fears of a link between infection and autoimmunity …
[False aneurysm of the pulmonary artery secondary to a cancer recurrence].
Millet A, Morel H, Heautot JF, Corre R, Curran Y. Millet A, et al. Presse Med. 2008 Dec;37(12):1817-9. doi: 10.1016/j.lpm.2007.10.021. Epub 2008 Sep 6. Presse Med. 2008. PMID: 18774678 French. No abstract available.
[Pathophysiology of ANCA-associated vasculitides].
Mouthon L, Millet A, Régent A, Pederzoli-Ribeil M, Witko-Sarsat V. Mouthon L, et al. Among authors: millet a. Presse Med. 2012 Oct;41(10):996-1003. doi: 10.1016/j.lpm.2012.07.007. Epub 2012 Aug 23. Presse Med. 2012. PMID: 22921085 Review. French.
Two phenotypes of GPA can be distinguished: a granulomatous form, localized to the respiratory tract with Th1 immune response features, and a vasculitic form with Th2 immune response features. Recently, an increase in TH17 lymphocytes at the acute phase and a
Two phenotypes of GPA can be distinguished: a granulomatous form, localized to the respiratory tract with Th1 immune response feature …
Republished: Antineutrophil cytoplasmic antibody-associated vasculitides: is it time to split up the group?
Millet A, Pederzoli-Ribeil M, Guillevin L, Witko-Sarsat V, Mouthon L. Millet A, et al. Postgrad Med J. 2014 May;90(1063):290-6. doi: 10.1136/postgradmedj-2013-203255rep. Postgrad Med J. 2014. PMID: 24737903 Review.
Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitides are a heterogeneous group of diseases corresponding to necrotising inflammation of small vessels with a wide range of clinical presentations. ...We have summarised these results and discuss the idea …
Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitides are a heterogeneous group of diseases corresponding to necrotising …
Antineutrophil cytoplasmic antibody-associated vasculitides: is it time to split up the group?
Millet A, Pederzoli-Ribeil M, Guillevin L, Witko-Sarsat V, Mouthon L. Millet A, et al. Ann Rheum Dis. 2013 Aug;72(8):1273-9. doi: 10.1136/annrheumdis-2013-203255. Epub 2013 Apr 20. Ann Rheum Dis. 2013. PMID: 23606701 Review.
Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitides are a heterogeneous group of diseases corresponding to necrotising inflammation of small vessels with a wide range of clinical presentations. ...We have summarised these results and discuss the idea …
Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitides are a heterogeneous group of diseases corresponding to necrotising …
Molecular analysis of the membrane insertion domain of proteinase 3, the Wegener's autoantigen, in RBL cells: implication for its pathogenic activity.
Kantari C, Millet A, Gabillet J, Hajjar E, Broemstrup T, Pluta P, Reuter N, Witko-Sarsat V. Kantari C, et al. Among authors: millet a. J Leukoc Biol. 2011 Nov;90(5):941-50. doi: 10.1189/jlb.1210695. Epub 2011 Aug 5. J Leukoc Biol. 2011. PMID: 21821719
PR3, also called myeloblastin, is a neutrophil serine protease that promotes myeloid cell proliferation by cleaving the cyclin-dependent kinase inhibitor p21(cip1/waf1). In addition, it is the target of ANCA in GPA, a necrotizing vasculitis. Anti-PR3 ANCA binding to …
PR3, also called myeloblastin, is a neutrophil serine protease that promotes myeloid cell proliferation by cleaving the cyclin-depend …
Proteinase 3, the autoantigen in granulomatosis with polyangiitis, associates with calreticulin on apoptotic neutrophils, impairs macrophage phagocytosis, and promotes inflammation.
Gabillet J, Millet A, Pederzoli-Ribeil M, Tacnet-Delorme P, Guillevin L, Mouthon L, Frachet P, Witko-Sarsat V. Gabillet J, et al. Among authors: millet a. J Immunol. 2012 Sep 1;189(5):2574-83. doi: 10.4049/jimmunol.1200600. Epub 2012 Jul 27. J Immunol. 2012. PMID: 22844112
Proteinase 3 (PR3) is the target of anti-neutrophil cytoplasm Abs in granulomatosis with polyangiitis, a form of systemic vasculitis. ...Calreticulin (CRT), a protein involved in apoptotic cell recognition, was found to be a new PR3 partner coexpressed with P …
Proteinase 3 (PR3) is the target of anti-neutrophil cytoplasm Abs in granulomatosis with polyangiitis, a form of systemic vasculitis. …
Proteinase 3 on apoptotic cells disrupts immune silencing in autoimmune vasculitis.
Millet A, Martin KR, Bonnefoy F, Saas P, Mocek J, Alkan M, Terrier B, Kerstein A, Tamassia N, Satyanarayanan SK, Ariel A, Ribeil JA, Guillevin L, Cassatella MA, Mueller A, Thieblemont N, Lamprecht P, Mouthon L, Perruche S, Witko-Sarsat V. Millet A, et al. J Clin Invest. 2015 Nov 2;125(11):4107-21. doi: 10.1172/JCI78182. Epub 2015 Oct 5. J Clin Invest. 2015. PMID: 26436651 Free PMC article.
This response required the IL-1R1/MyD88 signaling pathway and was dependent on the synthesis of NO, as macrophages from animals lacking these pathways did not exhibit a PR3-associated proinflammatory response. ...Concomitant injection of anti-PR3 ANCAs with PR3-expressing …
This response required the IL-1R1/MyD88 signaling pathway and was dependent on the synthesis of NO, as macrophages from animals lacking thes …
Characterization of cytosolic proliferating cell nuclear antigen (PCNA) in neutrophils: antiapoptotic role of the monomer.
De Chiara A, Pederzoli-Ribeil M, Mocek J, Candalh C, Mayeux P, Millet A, Witko-Sarsat V. De Chiara A, et al. Among authors: millet a. J Leukoc Biol. 2013 Oct;94(4):723-31. doi: 10.1189/jlb.1212637. Epub 2013 Jul 3. J Leukoc Biol. 2013. PMID: 23825390
We have shown previously that PCNA, a nuclear factor involved in DNA replication and repair in proliferating cells, is localized exclusively in the cytoplasm of neutrophils, where it regulates their survival. ...This study tested the hypothesis that monomeric PCNA could ha …
We have shown previously that PCNA, a nuclear factor involved in DNA replication and repair in proliferating cells, is localized excl …
Calreticulin Release at an Early Stage of Death Modulates the Clearance by Macrophages of Apoptotic Cells.
Osman R, Tacnet-Delorme P, Kleman JP, Millet A, Frachet P. Osman R, et al. Among authors: millet a. Front Immunol. 2017 Aug 23;8:1034. doi: 10.3389/fimmu.2017.01034. eCollection 2017. Front Immunol. 2017. PMID: 28878781 Free PMC article.
Calreticulin (CRT) is a well-known "eat-me" signal harbored by dying cells participating in their recognition by phagocytes. ...We observed that exogenous CRT is endocytosed by THP1 macrophages through macropinocytosis and that internalization is associated with a p …
Calreticulin (CRT) is a well-known "eat-me" signal harbored by dying cells participating in their recognition by phagocytes. ...We ob …
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