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975 results
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Exploiting the PI3K/AKT pathway for cancer drug discovery.
Hennessy BT, Smith DL, Ram PT, Lu Y, Mills GB. Hennessy BT, et al. Nat Rev Drug Discov. 2005 Dec;4(12):988-1004. doi: 10.1038/nrd1902. Nat Rev Drug Discov. 2005. PMID: 16341064 Review.
Efficient CD28 signalling leads to increases in the kinase activities of the TEC family tyrosine kinase EMT/ITK/TSK and the SRC family tyrosine kinase LCK.
Gibson S, Truitt K, Lu Y, Lapushin R, Khan H, Imboden JB, Mills GB. Gibson S, et al. Biochem J. 1998 Mar 15;330 ( Pt 3)(Pt 3):1123-8. doi: 10.1042/bj3301123. Biochem J. 1998. PMID: 9494076 Free PMC article.
PIK3CA is implicated as an oncogene in ovarian cancer.
Shayesteh L, Lu Y, Kuo WL, Baldocchi R, Godfrey T, Collins C, Pinkel D, Powell B, Mills GB, Gray JW. Shayesteh L, et al. Nat Genet. 1999 Jan;21(1):99-102. doi: 10.1038/5042. Nat Genet. 1999. PMID: 9916799
Lysophosphatidic acid induces urokinase secretion by ovarian cancer cells.
Pustilnik TB, Estrella V, Wiener JR, Mao M, Eder A, Watt MA, Bast RC Jr, Mills GB. Pustilnik TB, et al. Clin Cancer Res. 1999 Nov;5(11):3704-10. Clin Cancer Res. 1999. PMID: 10589790
The PTEN/MMAC1/TEP tumor suppressor gene decreases cell growth and induces apoptosis and anoikis in breast cancer cells.
Lu Y, Lin YZ, LaPushin R, Cuevas B, Fang X, Yu SX, Davies MA, Khan H, Furui T, Mao M, Zinner R, Hung MC, Steck P, Siminovitch K, Mills GB. Lu Y, et al. Oncogene. 1999 Nov 25;18(50):7034-45. doi: 10.1038/sj.onc.1203183. Oncogene. 1999. PMID: 10597304
Overexpression of edg-2/vzg-1 induces apoptosis and anoikis in ovarian cancer cells in a lysophosphatidic acid-independent manner.
Furui T, LaPushin R, Mao M, Khan H, Watt SR, Watt MA, Lu Y, Fang X, Tsutsui S, Siddik ZH, Bast RC, Mills GB. Furui T, et al. Clin Cancer Res. 1999 Dec;5(12):4308-18. Clin Cancer Res. 1999. PMID: 10632375
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