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Structure of the C3HC4 domain by 1H-nuclear magnetic resonance spectroscopy. A new structural class of zinc-finger.
Barlow PN, Luisi B, Milner A, Elliott M, Everett R. Barlow PN, et al. Among authors: milner a. J Mol Biol. 1994 Mar 25;237(2):201-11. doi: 10.1006/jmbi.1994.1222. J Mol Biol. 1994. PMID: 8126734
A recently identified sequence motif, referred to as "C3HC4" (also "RING finger" and "A Box") for its distinctive pattern of putative metal-binding residues, has been found in a wide range of proteins. ...We showed that the equine herpes virus protein binds z
A recently identified sequence motif, referred to as "C3HC4" (also "RING finger" and "A Box") for its distinctive pattern of p
A novel arrangement of zinc-binding residues and secondary structure in the C3HC4 motif of an alpha herpes virus protein family.
Everett RD, Barlow P, Milner A, Luisi B, Orr A, Hope G, Lyon D. Everett RD, et al. Among authors: milner a. J Mol Biol. 1993 Dec 20;234(4):1038-47. doi: 10.1006/jmbi.1993.1657. J Mol Biol. 1993. PMID: 8263911
A highly conserved, cysteine-rich region plays a crucial role in the function of a family of regulatory proteins encoded by alpha herpes viruses. ...Starting from the N terminus, this consists of an ordered but irregular loop, the first two strands of a
A highly conserved, cysteine-rich region plays a crucial role in the function of a family of regulatory proteins encode
Structural determinants present in the C-terminal binding protein binding site of adenovirus early region 1A proteins.
Molloy DP, Milner AE, Yakub IK, Chinnadurai G, Gallimore PH, Grand RJ. Molloy DP, et al. Among authors: milner ae. J Biol Chem. 1998 Aug 14;273(33):20867-76. doi: 10.1074/jbc.273.33.20867. J Biol Chem. 1998. PMID: 9694833
An Ad12 peptide bearing a substitution that resulted in only very weak binding to CtBP (Ad12 L258G) was found to be random coil in solution. However, a second mutant (Ad12 V256K), which bound to CtBP rather more strongly (although not as well as the wild type), adop …
An Ad12 peptide bearing a substitution that resulted in only very weak binding to CtBP (Ad12 L258G) was found to be random coil in so …
The structure of the site on adenovirus early region 1A responsible for binding to TATA-binding protein determined by NMR spectroscopy.
Molloy DP, Smith KJ, Milner AE, Gallimore PH, Grand RJ. Molloy DP, et al. Among authors: milner ae. J Biol Chem. 1999 Feb 5;274(6):3503-12. doi: 10.1074/jbc.274.6.3503. J Biol Chem. 1999. PMID: 9920896
The structure of a 19-residue Ad5 CR3 peptide carrying the V147L mutation in the full-length protein that abolishes TBP binding was examined. ...
The structure of a 19-residue Ad5 CR3 peptide carrying the V147L mutation in the full-length protein that abolishes TBP binding was e …
Adenovirus early region 1A protein binds to mammalian SUG1-a regulatory component of the proteasome.
Grand RJ, Turnell AS, Mason GG, Wang W, Milner AE, Mymryk JS, Rookes SM, Rivett AJ, Gallimore PH. Grand RJ, et al. Among authors: milner ae. Oncogene. 1999 Jan 14;18(2):449-58. doi: 10.1038/sj.onc.1202304. Oncogene. 1999. PMID: 9927201
Adenovirus early region 1A (Ad E1A) is a multifunctional protein which is essential for adenovirus-mediated transformation and oncogenesis. ...One of these interacting species has been identified as mammalian SUGI, a proteasome regulatory component which also plays …
Adenovirus early region 1A (Ad E1A) is a multifunctional protein which is essential for adenovirus-mediated transformation and oncoge …
Regeneration of the binding properties of adenovirus 12 early region 1A proteins after preparation under denaturing conditions.
Grand RJ, Gash L, Milner AE, Molloy DP, Szestak T, Turnell AS, Gallimore PH. Grand RJ, et al. Among authors: milner ae. Virology. 1998 Apr 25;244(1):230-42. doi: 10.1006/viro.1998.9081. Virology. 1998. PMID: 9581794
While the binding of the 266- and 235-amino-acid (aa) E1A components to TBP showed similar characteristics the larger E1A protein had a higher affinity for CtBP, pRb, and SUG1. ...
While the binding of the 266- and 235-amino-acid (aa) E1A components to TBP showed similar characteristics the larger E1A protein had a
Homology between a human apoptosis specific protein and the product of APG5, a gene involved in autophagy in yeast.
Hammond EM, Brunet CL, Johnson GD, Parkhill J, Milner AE, Brady G, Gregory CD, Grand RJ. Hammond EM, et al. Among authors: milner ae. FEBS Lett. 1998 Apr 3;425(3):391-5. doi: 10.1016/s0014-5793(98)00266-x. FEBS Lett. 1998. PMID: 9563500
The cDNA encoding ASP has been cloned from a human expression library and has significant homology to the Saccharomyces cerevisiae APG5 gene which is essential for yeast autophagy. ...These data indicate a possible relationship between apoptosis and autophagy and su …
The cDNA encoding ASP has been cloned from a human expression library and has significant homology to the Saccharomyces cerevisiae AP …
Human cells arrest in S phase in response to adenovirus 12 E1A.
Grand RJ, Ibrahim AP, Taylor AM, Milner AE, Gregory CD, Gallimore PH, Turnell AS. Grand RJ, et al. Among authors: milner ae. Virology. 1998 May 10;244(2):330-42. doi: 10.1006/viro.1998.9102. Virology. 1998. PMID: 9601504
Human tumor (A549, KB, and HeLa) cells were infected with Ad12 d/620, a mutant virus which has a lesion in the E1B gene and essentially expresses only E1A. ...The expression of cyclins A, B1, and E in the tumor cells increased appreciably in response to E1A. …
Human tumor (A549, KB, and HeLa) cells were infected with Ad12 d/620, a mutant virus which has a lesion in the E1B gene and es …
Apoptosis-specific protein (ASP) identified in apoptotic Xenopus thymus tumor cells.
Horton J, Milner A, Horton T, Ritchie P, Gascoyne D, Hewson T, Hammond E, Gregory C, Grand R. Horton J, et al. Among authors: milner a. Dev Immunol. 1998;5(4):333-48. doi: 10.1155/1998/70616. Dev Immunol. 1998. PMID: 9814588 Free PMC article.
A novel apoptosis-specific protein (ASP) has recently been identified in the cytoplasm of apoptotic mammalian cells. This paper investigates whether ASP is found in Xenopus thymus tumor-derived lymphoid cell lines undergoing apoptosis and also in apoptotic, nontransformed
A novel apoptosis-specific protein (ASP) has recently been identified in the cytoplasm of apoptotic mammalian cells. This paper inves
Three restricted forms of Epstein-Barr virus latency counteracting apoptosis in c-myc-expressing Burkitt lymphoma cells.
Kelly GL, Milner AE, Baldwin GS, Bell AI, Rickinson AB. Kelly GL, et al. Among authors: milner ae. Proc Natl Acad Sci U S A. 2006 Oct 3;103(40):14935-40. doi: 10.1073/pnas.0509988103. Epub 2006 Sep 25. Proc Natl Acad Sci U S A. 2006. PMID: 17001014 Free PMC article.
Epstein-Barr virus (EBV), a human herpesvirus, transforms B cell growth in vitro through expressing six virus-coded Epstein-Barr nuclear antigens (EBNAs) and two latent membrane proteins (LMPs). ...Interclonal comparisons showed that each form of EBV infection was associat …
Epstein-Barr virus (EBV), a human herpesvirus, transforms B cell growth in vitro through expressing six virus-coded Epstein-Barr nucl …
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